Initiative to combat pandemic influenza H1N1SW studies to understand transmission & responses in pig populations
Lead Research Organisation:
Biotechnology and Biological Sciences Research Council
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
This award is for two integrated projects to study the effect of influenza H1N1 (swine origin) in pig populations and also to epidemiologically map and model the spread of infection within pig populations
People |
ORCID iD |
| Simon Kerley (Principal Investigator) |
Publications
Barbara Wieland (Author)
(2012)
Towards risk based surveillance for Swine Influenza
Bhatt S
(2011)
The genomic rate of molecular adaptation of the human influenza A virus.
in Molecular biology and evolution
Bhatt S
(2013)
The evolutionary dynamics of influenza A virus adaptation to mammalian hosts.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Bourret V
(2012)
Development of an improved polykaryon-based influenza virus rescue system.
in BMC biotechnology
Bourret V
(2013)
Whole-genome, deep pyrosequencing analysis of a duck influenza A virus evolution in swine cells.
in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Fragaszy E
(2016)
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
in Influenza and other respiratory viruses
G White (Author)
(2011)
Pigs and the H1N1 pandemic: innate immune responses to experimentally infected pigs
Ian Brown (Author)
(2011)
Pandemic H1N1 : ?One health? discovery with emphasis on the veterinary sector
| Description | Ongoing advice to various government bodies and WHO |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Capacity and Capability Challenge (CCC) Programme grant |
| Amount | £25,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 05/2011 |
| Description | FLUPIG: FP7 258084 |
| Amount | £405,200 (GBP) |
| Funding ID | 258084 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 07/2010 |
| End | 12/2014 |
| Description | FP7- ANTIGONE |
| Amount | £333,367 (GBP) |
| Funding ID | 278976 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2011 |
| End | 10/2016 |
| Description | NADIR- transnational access component for swine influenza |
| Amount | £100,000 (GBP) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2009 |
| End | 12/2013 |
| Description | Understanding influenza A virus: linking transmission, evolutionary dynamics, pathogenesis and immunity in pigs |
| Amount | £44,449,823 (GBP) |
| Funding ID | BB/L001330/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2019 |
| Title | Peptide binding motifs |
| Description | Peptide binding motifs have been determined for the MHC-1 molecules expressed by the in bred pigs owned by IAH. Tetramers are under development to analyse the influenza specific CD8 T cell responses using these reagents. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | This work is now being taken forward in the BBSRC sLOLA on swine influenza at the BBSRC Pirbright Institute |
| Title | Plasmids encoding whole influenza virus |
| Description | This material enables the elucidation of the viral proteins associated with the immune response |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2010 |
| Provided To Others? | Yes |
| Impact | This material will enable further dissection of the immune basis for cross influenza subtype protection and examination of the genetic correlates of infection |
| Title | Use of Pigs as a Model of Human Influenza |
| Description | This work has gone some way towards validating the use of pigs in research as invaluable and natural models of influenza in humans |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | BBSRC funded an sLOLA on swine influenza dynamics at the Pirbright Institute - and the model is being actively followed up in that programme |
| Title | Peptide binding motifs |
| Description | Peptide binding motifs have been determined for the MHC-1 molecules expressed by the in bred pigs owned by IAH. Tetramers are under development to analyse the influenza specific CD8 T cell responses using these reagents. |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | This work is now directly feeding into the BBSRC sLOLA on swine flu dynamics |
| Title | Influenza Virus Sequence Data |
| Description | Full genome viral sequence data has been made publicly available |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | substantial numbers of papers are being drafted on the basis of this work |
| Description | Dissemination of findings from the outbreak investigations in pigs- NPA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation at National Pig Association Meeting As part or larger programme of engagement, significantly contributed to engagement with specialist veterinary profession and aided ongoing research studies and national disease surveillance |
| Year(s) Of Engagement Activity | 2010 |
| Description | Dissemination of findings from the outbreak investigations in pigs-PVS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation at Pig Veterinary Society Meeting As part or larger programme of engagement, significantly contributed to engagement with specialist veterinary profession and aided ongoing research studies and national disease surveillance |
| Year(s) Of Engagement Activity | 2010 |
| Description | Dissemination of findings from the outbreak investigations in pigs-regional |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation at Regional veterinary, pig producer and pig company meetings no actual impacts realised to date |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.aiai.ed.ac.uk/project/bayesevidence |
| Description | Press release organised by the funders |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The results of the various funding programmes were summarised for a lay audience None obvious |
| Year(s) Of Engagement Activity | 2009 |
| Description | UK National Farmers Union Health Committee |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation to UK National Farmers Union Health Committee Part of an ongoing programme of dissemination of reserach and results to interested stakeholders. |
| Year(s) Of Engagement Activity | 2010,2011 |