UoNottingham Confidence in Concept2013
Lead Research Organisation:
University of Nottingham
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
| Richard Masterman (Principal Investigator) |
Publications
Batson J
(2017)
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
in ACS chemical biology
Blaxter L
(2017)
Neonatal head and torso vibration exposure during inter-hospital transfer.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Brook MS
(2016)
The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise.
in European journal of sport science
Brook MS
(2016)
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.
in The Journal of physiology
Cox E
(2017)
Multiparametric Renal Magnetic Resonance Imaging: Validation, Interventions, and Alterations in Chronic Kidney Disease
in Frontiers in Physiology
Cox EF
(2019)
Using MRI to study the alterations in liver blood flow, perfusion, and oxygenation in response to physiological stress challenges: Meal, hyperoxia, and hypercapnia.
in Journal of magnetic resonance imaging : JMRI
Dellschaft NS
(2020)
The haemodynamics of the human placenta in utero.
in PLoS biology
Ding Y
(2017)
Novel Methods for Microglia Segmentation, Feature Extraction, and Classification.
in IEEE/ACM transactions on computational biology and bioinformatics
Hoad CL
(2016)
Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI.
in Neurogastroenterology and motility
| Description | Abbeyfield Foundation PhD Studentship |
| Amount | £86,214 (GBP) |
| Organisation | Abbeyfield |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Biomedical Research Centre Nottingham - Professor Philip Atherton |
| Amount | £23,600,000 (GBP) |
| Organisation | Royal Brompton & Harefield NHS Foundation Trust |
| Department | NIHR Biomedical Research Unit |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2017 |
| End | 03/2022 |
| Description | Dr Caroline Hoad: The causes of constipation. Reclassifying constipation using MRI and high resolution manometry to define mechanism of disease and target treatment |
| Amount | £1,600,000 (GBP) |
| Funding ID | MR/N026810/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2016 |
| End | 06/2019 |
| Description | Dr Henryk Faas: Monitoring enzyme activity with a hyperpolarized MRI biosensor |
| Amount | £148,147 (GBP) |
| Funding ID | BB/N021460/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2017 |
| Description | EPSRC Impact Acceleration Award |
| Amount | £15,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2014 |
| End | 12/2014 |
| Description | NIHR i4i Programme award |
| Amount | £665,505 (GBP) |
| Funding ID | II-LA-0813-20001 |
| Organisation | National Institute for Health Research |
| Department | NIHR i4i Invention for Innovation (i4i) Programme |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 02/2016 |
| Description | Prof David Bates: NEWTON - Role of heparin binding growth factors in O.viverrini induced Cholangiocarcinoma (O-CCA) development, progression and angiogenesis. |
| Amount | £368,828 (GBP) |
| Funding ID | MR/N01247X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2018 |
| Description | Prof Ioan Notingher: Accelerating the impact of Raman spectral imaging for detection of breast tumour margins during surgery |
| Amount | £25,500 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Prof Ioan Notingher: Extensive market research for breast cancer and to determine additional clinical opportunities for the multiplex multimodal spectral imaging technique |
| Amount | £15,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Prof Richard Bowtell: Structure and function of the placenta from implantation to delivery: a next generation MRI approach |
| Amount | $346,500 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| Description | Professor David Bates |
| Amount | £93,709 (GBP) |
| Organisation | Sight Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2020 |
| Description | Professor David Bates - MRC Project Grant |
| Amount | £369,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Professor David Bates - Skin Cancer Research Fund |
| Amount | £30,000 (GBP) |
| Organisation | The Skin Cancer Research Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Professor David Bates - South African MRC |
| Amount | R9,000,000 (ZAR) |
| Organisation | South African Medical Research Centre |
| Sector | Public |
| Country | South Africa |
| Start | |
| Description | The anabolic efficacy of GLP-1 agonism to prevent lean muscle losses during very low-calorie diets (VLCD's) for weight loss |
| Amount | £73,386 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2022 |
| Description | Prof David Bates: Exonate |
| Organisation | Exonate |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Screening of compounds for treatment of wet AMD |
| Collaborator Contribution | Supply of novel compounds for a number of therapeutic areas. |
| Impact | None yet |
| Start Year | 2016 |
| Description | Sanofi-Aventis Phase IV clinical trial, Dulcolax® |
| Organisation | Sanofi |
| Department | Aventis |
| Country | France |
| Sector | Private |
| PI Contribution | Delivery of Phase IV clinical trial to evaluate the mode of action of multiple doses of Dulcolax® in patients with occasional constipation |
| Collaborator Contribution | Financial |
| Impact | None yet |
| Start Year | 2019 |
| Company Name | Exonate Limited |
| Description | Exonate's strategy is to exploit its unique ability to alter mRNA splicing to create medicines developed through in-house product development and strategic partnerships. Exonate now has a lead candidate under development for the treatment of wet age-related macular degeneration (wAMD). It has the capacity to be administered as an eye drop rather than the currently available drugs which are given as intravitreal injections. As SPHINXes are small molecules, they will be inexpensive to manufacture and administer than alternative biologic therapeutics. |
| Year Established | 2014 |
| Impact | Exonate has closed its second round of funding with £792k of investment. |
| Website | http://exonate.com/ |