Accelerating translational research through Cardiff University’s Clinical Innovation pipeline
Lead Research Organisation:
Cardiff University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Avery SJ
(2017)
Analysing the bioactive makeup of demineralised dentine matrix on bone marrow mesenchymal stem cells for enhanced bone repair.
in European cells & materials
Bettencourt C
(2016)
DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
in Annals of neurology
Brown S
(2022)
Identifying the Efficacy of Extracellular Vesicles in Osteogenic Differentiation: An EV-Lution in Regenerative Medicine
in Frontiers in Dental Medicine
Clement M
(2019)
Cytokine-Mediated Induction and Regulation of Tissue Damage During Cytomegalovirus Infection
in Frontiers in Immunology
Ellis N
(2020)
Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease.
in Biological psychiatry
Gilbert SJ
(2018)
Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis.
in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Goold R
(2019)
FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
in Human molecular genetics
Houston DMJ
(2017)
In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection.
in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
| Description | CHDI Foundation |
| Amount | £141,000 (GBP) |
| Organisation | CHDI Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 02/2016 |
| End | 01/2018 |
| Description | Cardiff Partnership Fund |
| Amount | £40,000 (GBP) |
| Organisation | Cardiff Partnership Fund |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | DNA repair in Huntington's disease and other repeat-associated disorders |
| Amount | £150,321 (GBP) |
| Funding ID | 109088/Z/15/A |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2019 |
| Description | DOMINO-HD study (Multi-Domain Lifestyle Targets for Improving ProgNOsis) |
| Amount | £1,804,280 (GBP) |
| Organisation | EU Joint Programme - Neurodegenerative Disease Research (JPND) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2019 |
| End | 04/2022 |
| Description | DTG Studentship |
| Amount | £100,000 (GBP) |
| Funding ID | 1943693 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 03/2021 |
| Description | Development of Cytomegalovirus-Based Vectors in Cancer Vaccination |
| Amount | £90,000 (GBP) |
| Funding ID | 1943686 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 03/2022 |
| Description | Dunhill Medical Research Trust |
| Amount | £84,104 (GBP) |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | EHDN Seed Fund |
| Amount | £30,000 (GBP) |
| Organisation | European Huntington's Disease Network (Euro-HD) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 05/2015 |
| End | 05/2016 |
| Description | Identifying a utility for dentally derived extracellular vesicles to restore impaired bone healing associated with age-related systemic conditions |
| Amount | £127,451 (GBP) |
| Funding ID | RPGF1806/43 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2021 |
| Description | Life Sciences Bridging Fund |
| Amount | £60,000 (GBP) |
| Organisation | Government of Wales |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2017 |
| Description | Life Sciences Bridging Fund |
| Amount | £75,000 (GBP) |
| Organisation | Welsh Assembly |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2018 |
| Description | Life Sciences Research Network Wales |
| Amount | £50,000 (GBP) |
| Organisation | Welsh Assembly |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 07/2017 |
| Description | MRC Fellowship |
| Amount | £304,780 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 08/2018 |
| Description | Renishaw Ltd |
| Amount | £50,000 (GBP) |
| Organisation | Renishaw PLC |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Senior Fellowship in Basic Biomedical Sciences |
| Amount | £1,950,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2023 |
| Description | The role of innate immune regulation in viral pathogenesis and the development of anti-viral T cell memory |
| Amount | £1,942,612 (GBP) |
| Funding ID | 207503/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 01/2022 |
| Description | Using whole exome sequencing to identify genetic modifiers of Huntington's Disease |
| Amount | £30,000 (GBP) |
| Organisation | Brain Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 07/2019 |
| Description | Wellcome ISSF |
| Amount | £40,000 (GBP) |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Strategic Award |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Title | Target Evaluation Protocol for MSH3 |
| Description | Target Evaluation Protocol for MSH3 protein for use in investigation of mechanisms of Huntington's Disease |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | tbc |
| Title | cell-based assay for somatic instability |
| Description | cell-based assay for somatic instability |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | n/a |
| Title | dental pulp stem cells |
| Description | dental pulp stem cells banked |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | n/a |
| Title | fMRI neurofeedback protocol reregistration |
| Description | Gradual real-time fMRI neurofeedback training of motor imagery in middle cerebral artery stroke patients |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | ongoing |
| URL | https://osf.io/7q68p |
| Description | Bioeden |
| Organisation | BioEden Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The project provided preliminary results for the submission in September 2016 of a grant to the European Research Council (€1.5M). The research proposal matches funding criteria for providing highly novel interdisciplinarly research, supported by strongly established collaborative research network to aid successful development of new avenues for the therapeutic application of dental pulp derived mesenchymal stem cells in tissue engineering. |
| Collaborator Contribution | This project has cemented a collaborative partnership with Dr Mike Byrom of BioEden, providing cells in addition to translational direction. Dental pulp stem cells (received from our industrial collaborator, BioEden) |
| Impact | Submission in September 2016 of a grant to the European Research Council (€1.5M). |
| Start Year | 2016 |
| Description | Locate Therapeutics |
| Organisation | Locate Therapeutics Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | preparation of proposal for industry funding |
| Collaborator Contribution | preparation of proposal for industry funding |
| Impact | preparation of proposal for industry funding |
| Start Year | 2016 |
| Description | Mission |
| Organisation | MISSION Therapeutics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | potential exploitation of our assay and parallel mouse experiments. |
| Collaborator Contribution | potential exploitation of our assay and parallel mouse experiments. |
| Impact | potential exploitation of our assay and parallel mouse experiments. |
| Start Year | 2016 |
| Description | Neem Collaboration |
| Organisation | Neem Biotech |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Potential license scoping |
| Collaborator Contribution | Technical input |
| Impact | n/a |
| Start Year | 2018 |
| Description | Septodont |
| Organisation | Septodont Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | preparation of proposal for industry funding |
| Collaborator Contribution | preparation of proposal for industry funding |
| Impact | preparation of proposal for industry funding |
| Start Year | 2016 |
| Description | Teva |
| Organisation | TEVA Pharmaceuticals |
| Country | Israel |
| Sector | Private |
| PI Contribution | potential exploitation of our assay and parallel mouse experiments. |
| Collaborator Contribution | potential exploitation of our assay and parallel mouse experiments. |
| Impact | potential exploitation of our assay and parallel mouse experiments. |
| Start Year | 2016 |
| Title | Liposomal drug delivery system for bone cements |
| Description | The invention relates to a novel antibiotic delivery vehicle for impregnating bone cement wherein said vehicle is an antibiotic encapsulated liposome having a block co-polymer on its surface; a method for the manufacture of a bone cement impregnated with antibiotic or a mixture of antibiotics using said vehicle; and also a novel bone cement made therewith and/or thereby. |
| IP Reference | US20160158405 |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | n/a |
| Title | Permipatch |
| Description | Permipatch |
| IP Reference | |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | n/a |
| Description | British Transplant Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | presented nationally and internationally at 'British Transplant Society' conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Conferece abstract |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Supplementary motor area, but not primary motor cortex - gradual real-time fMRI neurofeedback training and its translation to stroke patients. 28th Symposium on Cerebral Blood Flow, Metabolism and Function and 13th Conference on Quantification of Brain Function with PET, Berlin, Germany |
| Year(s) Of Engagement Activity | 2017 |
| Description | Conference abstract |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Supplementary motor area, but not primary motor cortex - upper limb gradual fMRI neurofeedback. Organization of Human Brain Mapping, 23rd Scientific Meeting, Vancouver, British Columbia, Canada. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Conference abstract |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Supplementary motor area, but not primary motor cortex - Translating graded real-time fMRI neurofeedback training to middle cerebral artery stroke (MCA) patients. real time functional imaging and neurofeedback conference, 3rd Scientific Meeting, Nara, Japan. |
| Year(s) Of Engagement Activity | 2017 |
| Description | ESOT |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | presented at 'European Society for Organ Transplantation' conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Industry Stakeholder Event |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Industry delegates attended Medical Device Symposium relating to fMRI neurofeedback field |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.uc.pt/en/fmuc/ibili/MedicalDeviceSymposium/Agenda |
| Description | Invited Speaker - International Association for Dental Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International Association for Dental Research as an Invited Speaker |
| Year(s) Of Engagement Activity | 2019 |
| Description | Scientific Programme |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International Conference of the Chemistry and Biology of Mineralised Tissue - part of the scientific programme |
| Year(s) Of Engagement Activity | 2018 |