Maximising patient benefit: Leeds’ Interdisciplinary approach to translation
Lead Research Organisation:
University of Leeds
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
Paul Stewart (Principal Investigator) |
Publications
Armistead FJ
(2020)
Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells.
in Scientific reports
Armistead FJ
(2019)
Cells Under Stress: An Inertial-Shear Microfluidic Determination of Cell Behavior.
in Biophysical journal
Bao P
(2019)
Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides.
in Lab on a chip
Bao P
(2021)
Production of giant unilamellar vesicles and encapsulation of lyotropic nematic liquid crystals
in Soft Matter
Bartoli F
(2020)
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.
in Circulation
Batchelor D
(2021)
Nanobubbles for therapeutic delivery: Production, stability and current prospects
in Current Opinion in Colloid & Interface Science
Batchelor DVB
(2020)
Nested Nanobubbles for Ultrasound-Triggered Drug Release.
in ACS applied materials & interfaces
Bentley R
(2021)
Drugs in phase I and II clinical development for the prevention of stroke in patients with atrial fibrillation.
in Expert opinion on investigational drugs
Bondza S
(2017)
Real-time Characterization of Antibody Binding to Receptors on Living Immune Cells.
in Frontiers in immunology
Bourn MD
(2020)
High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures.
in Journal of controlled release : official journal of the Controlled Release Society
Charalambous A
(2021)
Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, combretastatin A4.
in Nanomedicine : nanotechnology, biology, and medicine
Clayton RN
(2016)
Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study.
in The lancet. Diabetes & endocrinology
Crowley RK
(2016)
SFRP2 Is Associated with Increased Adiposity and VEGF Expression.
in PloS one
Dineen R
(2017)
Acromegaly.
in QJM : monthly journal of the Association of Physicians
Foster H
(2020)
Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis.
in Journal of medicinal chemistry
Gala De Pablo J
(2020)
Detection and time-tracking activation of a photosensitiser on live single colorectal cancer cells using Raman spectroscopy.
in The Analyst
Gala De Pablo J
(2018)
Biochemical fingerprint of colorectal cancer cell lines using label-free live single-cell Raman spectroscopy.
in Journal of Raman spectroscopy : JRS
Hardy LJ
(2023)
Glycated albumin modulates the contact system with implications for the kallikrein-kinin and intrinsic coagulation systems.
in Journal of thrombosis and haemostasis : JTH
Hardy RS
(2016)
11ß-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.
in The Journal of pathology
Hepburn S
(2015)
An analysis of the impact of pre-analytical factors on the urine proteome: Sample processing time, temperature, and proteolysis.
in Proteomics. Clinical applications
Jenkinson C
(2016)
High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum.
in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Kearney K
(2021)
Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI
in Proceedings of the National Academy of Sciences
Keeley J
(2019)
Detection sensitivity of laser feedback interferometry using a terahertz quantum cascade laser.
in Optics letters
Kirkby CJ
(2021)
Developing a Raman spectroscopy-based tool to stratify patient response to pre-operative radiotherapy in rectal cancer.
in The Analyst
Larner DP
(2016)
Male 11ß-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease.
in Endocrinology
Lim YL
(2019)
Coherent imaging using laser feedback interferometry with pulsed-mode terahertz quantum cascade lasers.
in Optics express
Moorcroft SCT
(2020)
Nanoparticle-Loaded Hydrogel for the Light-Activated Release and Photothermal Enhancement of Antimicrobial Peptides.
in ACS applied materials & interfaces
Morgan SA
(2016)
Glucocorticoids and 11ß-HSD1 are major regulators of intramyocellular protein metabolism.
in The Journal of endocrinology
Rakic A
(2019)
Sensing and imaging using laser feedback interferometry with quantum cascade lasers
in Applied Physics Reviews
Roach L
(2018)
Morphological control of seedlessly-synthesized gold nanorods using binary surfactants.
in Nanotechnology
Roach L
(2018)
Corrigendum: Morphological control of seedlessly-synthesized gold nanorods using binary surfactants (2018 Nanotechnology 29 135601).
in Nanotechnology
Robinson JI
(2018)
Affimer proteins inhibit immune complex binding to Fc?RIIIa with high specificity through competitive and allosteric modes of action.
in Proceedings of the National Academy of Sciences of the United States of America
Rode B
(2018)
ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension.
in Physiology (Bethesda, Md.)
Shawer H
(2021)
ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling.
in Frontiers in cell and developmental biology
Stewart PM
(2016)
Exploring Inpatient Hospitalizations and Morbidity in Patients With Adrenal Insufficiency.
in The Journal of clinical endocrinology and metabolism
Tanaka M
(2019)
Rational screening of biomineralisation peptides for colour-selected one-pot gold nanoparticle syntheses
in Nanoscale Advances
Weigel M
(2017)
Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer.
in Clinical endocrinology
Ye S
(2019)
Sub-Nanometer Thick Gold Nanosheets: Sub-Nanometer Thick Gold Nanosheets as Highly Efficient Catalysts (Adv. Sci. 21/2019)
in Advanced Science
Ye S
(2020)
One-Step Preparation of Biocompatible Gold Nanoplates with Controlled Thickness and Adjustable Optical Properties for Plasmon-Based Applications
in Advanced Functional Materials
Ye S
(2019)
Sub-Nanometer Thick Gold Nanosheets as Highly Efficient Catalysts.
in Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Ye S
(2020)
Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells.
in Small (Weinheim an der Bergstrasse, Germany)
Description | Flight |
Amount | £8,484 (GBP) |
Organisation | The ITP Support Association |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2021 |
Description | HyperTerahertz - High precision terahertz spectroscopy and microscopy |
Amount | £6,517,861 (GBP) |
Funding ID | EP/P021859/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2017 |
End | 05/2022 |
Description | Optimising the affinity and format of a lead candidate biotherapeutic for the treatment of immune thrombocytopenia |
Amount | £28,576 (GBP) |
Funding ID | M866 |
Organisation | Rosetrees Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2019 |
End | 08/2022 |
Description | The impact of Fc gamma receptor polymorphisms on treatment response in adult patients with primary immune thrombocytopenia |
Amount | £25,992 (GBP) |
Organisation | British Medical Association (BMA) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2017 |
End | 09/2021 |