MRC and DfID contribution to jointly funded rapid response strategic award
Lead Research Organisation:
MRC Human Immunology Unit
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
We will investigate whether a clinical trial of an experimental vaccine can provide a valuable source of potentially therapeutic human monoclonal antibodies to Ebola.
We aim to isolate a cocktail of neutralizing human antibodies from vaccines to compare with the ZMapp cocktail derived from murine antibodies. ZMapp consists of 3 antibodies binding 2 sites, at the Base, and Receptor Binding Domain of the EBOV Glycoprotein.
We aim to isolate a cocktail of neutralizing human antibodies from vaccines to compare with the ZMapp cocktail derived from murine antibodies. ZMapp consists of 3 antibodies binding 2 sites, at the Base, and Receptor Binding Domain of the EBOV Glycoprotein.
Organisations
- MRC Human Immunology Unit (Lead Research Organisation)
- HUMABs Biomed, Bellinzona,Switzerland (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Scripps Research Institute (Collaboration)
- National Institute for Biological Standards and Control (NIBSC) (Collaboration)
- UCB Pharma (Collaboration)
- EBOVAC2 Consortium (Collaboration)
People |
ORCID iD |
Publications
Abd Hamid M
(2019)
Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses
in Cancer Immunology Research
Abd Hamid M
(2020)
Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses.
in Cancer immunology research
Bedard M
(2019)
Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells
in Proceedings of the National Academy of Sciences
Chen YL
(2020)
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
in The Journal of experimental medicine
Colin-York H
(2019)
Cytoskeletal Control of Antigen-Dependent T Cell Activation.
in Cell reports
Corridoni D
(2019)
NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.
in Frontiers in immunology
Giannoccaro M
(2019)
Behaviour and neuropathology in mice injected with human contactin-associated protein 2 antibodies
in Brain
Jin C
(2019)
Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model.
in PLoS neglected tropical diseases
Lange J
(2020)
The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes.
in ACS chemical biology
Li X
(2019)
A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
in Frontiers in oncology
| Description | MRC Capital Prioritisation Equipment Bid |
| Amount | £120,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2018 |
| Description | Collaboration with EBOVAC2 |
| Organisation | EBOVAC2 Consortium |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project and search through B cells of donors |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Collaboration with HUMABs, Switzerland |
| Organisation | HUMABs Biomed, Bellinzona,Switzerland |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project and supply of antibodies |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Collaboration with NIBSC |
| Organisation | National Institute for Biological Standards and Control (NIBSC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Collaboration with Public Health England |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Collaboration with UCB Celltech |
| Organisation | UCB Pharma |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Collaboration with the Viral Hemorrhagic Fever Immunotherapeutic Consortium |
| Organisation | Scripps Research Institute |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Isolation of a cocktail of neutralizing antibodies from vaccinees to compare with the ZMapp cocktail derived from murine antibodies |
| Collaborator Contribution | Collaborative project and supply of antibodies |
| Impact | No published outcome yet |
| Start Year | 2016 |
| Description | Article in WIMM Blog on invariant natural killer T cells |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | An article entitled "Lights, Camera, Immuno-action!" on WIMM Blog presenting research on invariant natural killer T cells, and the role they may be able to play in the fight against cancer. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.imm.ox.ac.uk/wimm-blog-2 |
| Description | Developing resources for teachers to use in classroom |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Working as part of team developing resources for teachers to help them enrich their curriculum with hands-on classroom activities, an existing activity that illustrates blood group compatibility to students was adapted and teaching materials for teachers were developed to conduct the experiment with students in classroom. This included the design of worksheets for the students and a detailed lesson plan for the teachers as well as introductory materials. A 3-minute animation explaining the immunological concepts underlying antibody-mediated immunity was written and produced. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Flow Cytometry Talk for In2Science work experience programme |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The aim was to introduce participants of the WIMM work experience programme to the basic concepts of flow cytometry; audience: high school age participants of the WIMM work experience programme |
| Year(s) Of Engagement Activity | 2018 |
| Description | Hands on activities at the Oxford Museum of Natural History |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | "The Blood Factory" - hands on activities about blood at the Museum of Natural History for secondary school students, adults etc. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Hands-on activities during Royal Society Summer Exhibition, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on activities, including virtual reality tour of DNA, during Royal Society Summer Science Exhibition, Royal Society London. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Hosting of an A-level student |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Last year we hosted Jasmine Godden, July 16-19 2018. She was a 6th former student at Cheney and was interested in Cancer Immunotherapy. She shadowed members of the Lab and discussed with them their research, then she wrote an essay on Cancer Immunotherapy in Melanoma. She got an A* for this work, as part of her EPQ. She now intends to apply for medical school. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Hosting of severl A-level Work Experience students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The Group hosted five A-level students from local schools for a period of Work Experience. Two of the students subsequently decided to go on to study medicine. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Festival of Medical Research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | To showcase and discuss the important work carried out in the Unit |
| Year(s) Of Engagement Activity | 2016 |
| Description | MRC Festival of Medical Research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in a co-organised event set up in a series of regional supermarkets to raise awareness of the research and science carried out by the MRC |
| Year(s) Of Engagement Activity | 2018 |
| Description | MRC Festival of Medical Research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We set up and organised the "Cancer Immunotherpy Stand" in the context of the yearly MRC Festival of Medical Research |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Festival of Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The aim was to inform and engage with the public about gene editing techniques; audience: passers-by in the Newbury pedestrian zone |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oxford Hands-On Science school visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The aim was to share enthusiasm for science with school pupils by taking hands-on science activities into classrooms; audience: local school children |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oxford Science and Ideas Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Our group set up a Cancer Immunotherapy stand at the Oxford Science and Ideas festival |
| Year(s) Of Engagement Activity | 2019 |
| Description | Oxfordshire Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | To showcase our multi-disciplinary department through interactive demonstrations and hands-on activities. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Participation in Summer Roadshow - part of Oxford Hands-On Science (OXHOS) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Participation in 2017 Summer Road Show by Oxford Hands-On Science - participating and help in organising activities in schools in and around Oxford in June and also a week of activities in various schools on the Isle of Wight in July. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://oxhos.org/PDFs/OxHOS_Roadshow_Report_Summer_2017.pdf |
| Description | Publication of glossy brochure for dissemination |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Development and publication of a glossy brochure illustrating in lay terms the important work carried out in the unit and dissemination to the general public. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Secondary school student one day visit to the lab |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Secondary school student visited research lab for one day and shadowed a Post Doc observing lab work and experiments. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Secondary school student visited research lab for work experience and one day shadowing. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A secondary school student visited immunology research lab to get work experience and observe scientists in their daily work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Teacher Training Evening |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The aim was to equip teachers to use teaching resources on antibodies and microscopy developed by Eggeling and Cerundolo labs to enhance science curriculum with hands-on activities |
| Year(s) Of Engagement Activity | 2018 |
| Description | Town and Gown Marathon |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Participation as the MRC Human Immunology team in the annual sponsored charity Town and Gown marathon |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit by 50 students from the Utrecht Junior School, the Netherlands |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | A group of 50 students from Utrecht Junior College in the Netherlands took place in the WIMM and the MRC Human Immunology Unit. 100% of students who attended said that they both enjoyed the day and learnt something new about science. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Volunteering in Settlers Exhibition, Oxford Museum of Natural History |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An Exhibition to raise awareness into DNA and VR |
| Year(s) Of Engagement Activity | 2018 |
| Description | Work experience visits by 5th & 6th year students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Work experience visits to the MRC Human Immunology Unit by a total of 19 students in 2016. |
| Year(s) Of Engagement Activity | 2016 |