MRC Confidence in Concept 2018 - University of Hull
Lead Research Organisation:
University of Hull
Department Name: UNLISTED
Abstract
MRC Confidence in Concept 2018 - University of Hull
Technical Summary
MRC Confidence in Concept 2018 - University of Hull
People |
ORCID iD |
| Maggie McGowan (Principal Investigator) |
Publications
Alzahrani SO
(2024)
trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors.
in Dalton transactions (Cambridge, England : 2003)
Haigh T
(2023)
The Use of Tissue-on-Chip Technology to Focus the Search for Extracellular Vesicle miRNA Biomarkers in Thyroid Disease.
in International journal of molecular sciences
Renard I
(2024)
Rigid Macrocycle Metal Complexes as CXCR4 Chemokine Receptor Antagonists: Influence of Ring Size
in Pharmaceutics
Renard I
(2023)
In vivo validation of 68Ga-labeled AMD3100 conjugates for PET imaging of CXCR4.
in Nuclear medicine and biology
Wilkinson HN
(2021)
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair.
in Journal of visualized experiments : JoVE
| Description | Influence International Atomic Energy Agency position on the future of multimodal medical imaging |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Contractual Research - |
| Amount | £114,321 (GBP) |
| Funding ID | CICA-UoH-MICREOS-01 |
| Organisation | Micreos |
| Sector | Private |
| Country | Netherlands |
| Start | 08/2020 |
| End | 08/2021 |
| Description | Exploiting microfluidic technology to predict chemoradiation responses in HNSCC |
| Amount | £10,000 (GBP) |
| Organisation | The Royal College of Surgeons of Edinburgh |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2022 |
| End | 05/2023 |
| Title | Optimised Ex vivo infected human wound model |
| Description | Optimised Ex vivo infected human wound model |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | this model has been adopted by others |
| Description | Development of radiobiological assays for assessment of copper-67 radiopharmaceuticals |
| Organisation | King's College London |
| Department | Division of Imaging Sciences and Biomedical Engineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have produced new copper-67 containing radiopharmaceuticals in Hull, These are therapeutic/ diagnostic agents that are being developed for cancer treatment. The compounds have been invented in the Archibald research group in Hull and tested in vivo. |
| Collaborator Contribution | In order to fully understand the value of the therapy with copper-67 the fundamentals of the cellular response to the emitted radiation need to be investigated. Dr Samantha Terry's group in the Department of Imaging Chemistry and Biology at King's College have knowledge and expertise and helped develop these assays for this project. This data is contributing to validation of the new cancer therapeutics and design of in vivo tumour therapy response experiments. |
| Impact | No outputs as yet. A grant application has been prepared for submission in 2022. |
| Start Year | 2021 |
| Description | F-star |
| Organisation | F-star Therapeutics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The PhD studentship that is being set up from the MRC CiC cluster is aligned with F-Star, who have given the University an additional grant for about £300k |
| Collaborator Contribution | The PhD studentship that is being set up from the MRC CiC cluster is aligned with F-Star, who have given the University an additional grant for about £300k |
| Impact | N/A |
| Start Year | 2021 |
| Description | Smith and Nephew |
| Organisation | Smith and Nephew |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development and evaluation of a new wound diagnostic device |
| Collaborator Contribution | Contributed funding, reagents and expertise |
| Impact | N/A |
| Start Year | 2019 |
| Description | Presentation to Bionow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Attended a Bionow Targeted oncology conference with academics, industry representatives and clinical leads. Gave a talk to this diverse audience on new models for radiopharmaceuticals development (using the technology developed in this grant). |
| Year(s) Of Engagement Activity | 2022 |
| Description | Presentation to UK pharmaceutical company |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Based on the work funded in this grant there a connection was made with a UK pharma company on collaboration and also future developments in the UK for radiopharmaceuticals. The presentation and discussion also involved US partners in the company. This increased interest in the research and potential future collaborations. It also informed the pharma company of activity in the UK in this area and led on to future meetings to develop a partnership for radiotracer production. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.blueearthdiagnostics.com/ |
| Description | School science talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The activity was designed to help A level science students understand interdisciplinary science in healthcare and the role of scientists in the NHS. It also showed how research translates out of university laboratories to clinical impact. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Talk to and hosting of visit by Chief Scientific Advisor (Paul Monks) to Department of Business, Energy and Industrial Strategy |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | We engaged with the Department of Business, Energy and Industrial Strategy to host a visit that would inform government about the challenges and issues with radioisotope supply for medical use across the UK. The visit and presentation also indicated potential solutions to these issues (including the science developed in this grant) and influenced the approach to tackling these issues for the benefit of the UK economy and general public (patients). |
| Year(s) Of Engagement Activity | 2022 |