Born in Bradford (BiB): An international resource for exploring lifecourse determinants of health, development and social wellbeing.
Lead Research Organisation:
University of Bristol
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
BiB is a is a multi-ethnic, deprived cohort and this enhancement will promote greater diversity and inclusion in proteomic research. It is a prospective pregnancy/family cohort that was established to examine how genomic, molecular, environmental, behavioural and social factors together affect health and wellbeing of families from a diverse population. Information and samples were collected from 11,396 women who delivered 13,818 live births from 2007-2011. The objectives of this grant are to: (i) generate serum proteomic data (450 proteins related to cardiovascular, metabolic and inflammatory processes) in BiB pregnancy samples; (ii) link these to existing data; (iii) complete QC; (iv) produce descriptive and genome-wide association summary data; and (iv) widely disseminate the availability of these data. These data could be ultilised to explore the role of deprivation, occupation, environmental (e.g. air and water pollution), behavioural (smoking, diet), and ancestry exposures on variation in protein levels, and the role of proteins in improving antenatal risk stratification, drug efficacy and safety in pregnancy, and potential mediation between exposures and pregnancy/perinatal and longer-term health outcomes. In addition, the proteomics could be combined with BiB exome sequence and genotype array data to explore effects of homozygosity (human knock-outs) and contribute to the largest trans-ethnic GWAS of proteins.
Organisations
- University of Bristol (Lead Research Organisation)
- University of Copenhagen (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- Erasmus MC (Collaboration)
- University of Groningen (Collaboration)
- University of Oulu (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Bradford Institute for Health Research (BIHR) (Collaboration)
- University of Turin (Collaboration)
- Barcelona Institute for Global Health (Collaboration)
- Bradford Teaching Hospitals NHS Foundation Trust (Collaboration)
- University of the Witwatersrand (Collaboration)
- Norwegian Institute of Public Health (Collaboration)
- Erasmus University Rotterdam (Collaboration)
- University of Queensland (Collaboration)
- University of Adelaide (Collaboration)
- Federal University of Pelotas (UFPel) (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Barry CS
(2022)
Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight.
in Metabolites
Borges MC
(2024)
Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes.
in BMC medicine
Cornish R
(2024)
Maternal pre-pregnancy body mass index and risk of preterm birth: a collaboration using large routine health datasets
in BMC Medicine
Decina C
(2023)
Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study
in International Journal of Epidemiology
Elhakeem A
(2023)
Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.
in BMC medicine
Elliott HR
(2022)
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans.
in Clinical epigenetics
Fragoso-Bargas N
(2023)
Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study.
in Diabetes
| Description | BHF Chair of Cardiovascular Science and Clinical Epidemiology |
| Amount | £508,351 (GBP) |
| Funding ID | CH/F/20/90003 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 04/2026 |
| Description | Born in Bradford Age of Wonder |
| Amount | £6,999,754 (GBP) |
| Funding ID | 223601/Z/21/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2028 |
| Description | Born in Scotland in the 2020s - Pilot study |
| Amount | £879,708 (GBP) |
| Funding ID | MR/V034294/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2021 |
| End | 03/2024 |
| Description | Developing and applying new statistical models to test for transgenerational effects of environmental exposures in pregnancy |
| Amount | kr 10,046,000 (NOK) |
| Funding ID | 325640 |
| Organisation | Research Council of Norway |
| Sector | Public |
| Country | Norway |
| Start | 09/2021 |
| End | 08/2024 |
| Description | Rapid call, Longitudinal Population Studies Enhancement Award for Born in Bradford to add pregnancy proteomics data |
| Amount | £771,566 (GBP) |
| Funding ID | MR/N024397/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 04/2022 |
| Description | The Born in Bradford COVID-19 Research Study: An adaptive mixed methods longitudinal study of the impact of COVID-19 on health inequalities in families living in Bradford |
| Amount | £198,680 (GBP) |
| Organisation | The Health Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2021 |
| Title | Metabolomics datasets in the Born in Bradford cohort |
| Description | This provides full details of all of the metabolomics data in the Born in Bradford study including details of how researchers (national and international) can access and use these |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Too early for impact |
| URL | https://wellcomeopenresearch.org/articles/5-264 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | Bradford Institute for Health Research (BIHR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | Federal University of Pelotas (UFPel) |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | University of Adelaide |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Birth cohorts metabolomics partnership |
| Organisation | University of the Witwatersrand |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites. |
| Collaborator Contribution | Established the cohort Applying for funds to extend it |
| Impact | None to date |
| Start Year | 2014 |
| Description | Evans/Warrington Group (University of Queensland) |
| Organisation | University of Queensland |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | We are currently collaborating on 4 papers, which are expected to be submitted within 6 months. Tom Bond (postdoc in Lawlor group) is leading analyses and manuscript writing on these projects. Tom Bond is an associate advisor to a PhD student (Geng Wang) jointly supervised with Dave Evans and Nicole Warrington. |
| Collaborator Contribution | Dave Evans, Nicole Warrington and their team members have provided methodological input to these projects |
| Impact | Multi disciplinary- epidemiology, statistical genetics |
| Start Year | 2020 |
| Description | LifeCycle - IVF cohort |
| Organisation | Barcelona Institute for Global Health |
| Country | Spain |
| Sector | Multiple |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | Erasmus University Rotterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | Norwegian Institute of Public Health |
| Country | Norway |
| Sector | Public |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | University of Groningen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | University of Southampton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | LifeCycle - IVF cohort |
| Organisation | University of Turin |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | We are the central organisers of the collaboration. We draft analysis plans, share these with partners, undertake individual participant study analyses and meta-analyses of data across all studies. We will write the first draft of initial papers and redraft following in put from partners |
| Collaborator Contribution | Partners: 1. Contribute to the development of analysis plans 2. Provide individual participant data or summary results 3. Contribute to drafting manuscripts |
| Impact | Too early for outputs |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | Bradford Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | Harvard University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | Norwegian Institute of Public Health |
| Country | Norway |
| Sector | Public |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | MR-PREG |
| Organisation | University of Oulu |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | Our contributions are: 1. Draft analysis plans 2. Complete analyses 3. Draft papers 4. Support other partners to lead projects |
| Collaborator Contribution | Partners contribute to: 1. Analysis plans. So far these have been initially written by my group but partners make important contributions to revising the first draft (before we begin analyses) and to any decisions about any revisions after analyses have started 2. Data provision and/or analyses. Participants provide individual participant data for analyses in Bristol and/or undertake analyses in their groups and provide summary results 3. Critical comments on drafted papers |
| Impact | Analyses have been completed but no publications yet. |
| Start Year | 2018 |
| Description | NTNU Trondheim |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Department | Department of Public Health and Nursing |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | We are currently collaborating on 1 paper, with further papers expected to be submitted within 1 year. Tom Bond (postdoc in Lawlor group) is leading analyses and manuscript writing on these projects. |
| Collaborator Contribution | Ben Brumpton, Bjorn-Olav Asvold and Laxmi Bhatta are running analyses in the HUNT cohort |
| Impact | Multi disciplinary- epidemiology, clinical medicine |
| Start Year | 2020 |
| Description | Developmental origins offspring adiposity |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release of research on the developmental origins of offspring adiposity, which gained international coverage in coventional media via large network of international scientists involved with the research. Was also re-twetted a lot. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Discussing COVID-19 research with children in schools- Louise Millard |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | IEU researchers have led online epidemiology sessions for students at two Bristol primary schools. Having outlined their own research, IEU researchers led the 11-year olds in devising their own epidemiology research questions about COVID-19 or the effects of the lockdown. Their questions included: Can eating chillies help prevent COVID-19? Can alcohol make COVID-19 worse? and Do people sleep more, less or the same in lockdown? The students then worked out how researchers might collect and process data to help them to work out the answers to their questions. Through so doing, they considered the challenges of working with incomplete data in rapid-response epidemiology. They also engaged with ideas of causality and the responsible communication of research findings. The 11-year olds greatly enjoyed the sessions, saying, "I enjoyed this experience because I learnt a lot about the process of how scientists study" and "It was good to meet scientists - I was inspired. |
| Year(s) Of Engagement Activity | 2020 |
| Description | I'm a scientist get me out of here |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Organised by MRC Public Engagement about Science and a career in science |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/supporting-education/im-a-scientist... |
| Description | MRC Parliamentary show case |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A group of MRC scientists had stalls at parliament for parliamentarians to discuss our research with us. Together with Max Palmer and Kate Hunt, I presented up dates in population health, including discussions of causal analyses, adaptive RCTs, data-sharing and record linkage |
| Year(s) Of Engagement Activity | 2017 |
| Description | Mayor of Bristol Young Peoples work & mentoring |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | This is a scheme that provides support and mentorship to 16-18 year olds from deprived backgrounds |
| Year(s) Of Engagement Activity | 2017 |
| Description | Neonatal Society Autumn Meeting (5th November 2020)- Neil Golding |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Several postgraduate and postdoctoral researchers from the University of Bristol (as well as other universities) presented their work at this meeting, which sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.neonatalsociety.ac.uk/wp-content/uploads/2020/10/The_Neonatal_Society_Abstracts_Nov-2020... |
| Description | Press release on smoking and congenital heart disease |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release and interviews covered in national papers, TV and local radio and TV. Research led by BHF Student showing potential effect of maternal smoking in pregnancy on congenital heart disease |
| Year(s) Of Engagement Activity | 2021 |