Substance use disorders among men in urban and rural communities in South Africa: Culture, treatment seeking and service provision

Lead Research Organisation: London School of Hygiene & Tropical Medicine
Department Name: Infectious and Tropical Diseases

Abstract

Men of lower socio-economic status in South Africa are more affected by substance use disorders (SUDs), and generally their use of treatment services is very low. Reasons for this are poorly understood but may be due to cultural factors. This study will describe what SUD treatment exists, evaluating barriers which prevent men using treatment services in 2 urban (Khayelitsha, Soshanguve) and 2 rural sites (King Dalindyebo, Madibeng) in South Africa. Specific objectives are to determine the: (1) how SUD treatment services are provided; (2) how demographic, cultural, economic, psychosocial factors and rural-urban migration influence men to seek treatment services; and (3) the burden and severity of SUDs, related common mental health disorders and associated factors.

We will conduct a detailed review of all treatment services in 3 study sites (in Khayelitsha an audit is already completed) providing services to men. One respondent (manager) will be interviewed in each service to collect information required. The influence of culture on how men with SUD seek treatment services will be explored in 32 in-depth interviews (8 per site) and 8 discussion groups (2 per site), and among SUDs treatment service providers in 24 in-depth interviews (6 per site). To determine the burden and severity of SUDs and associated health problems and risk factors, a household survey will be done in Year 2 in the Western Cape, Eastern Cape and North West provinces using random sampling of groups of households, targeting adult men 8 years and above (each N=547). We will also conduct a community survey in Soshanguve using a special sampling method (Respondent Driven Sampling) in Year 3 to estimate prevalence of nyaope use. Recruitment will involve a number of steps until the recommended sample size of 350 users is reached. Study findings will be presented to community stakeholders and key decision makers to propose interventions to improve treatment access.

Technical Summary

Substance use disorders (SUDs) disproportionately affect men of lower socio-economic status in South Africa, and treatment uptake is low. Reasons for this are poorly understood. This study examines the nature of SUD treatment provision, and obstacles to treatment-seeking among men in 2 urban (Khayelitsha, Soshanguve) and 2 rural sites (King Dalindyebo, Madibeng) in South Africa. Specific objectives are to determine the: (1) availability and nature of SUD treatment provision; (2) role of demographic, cultural, economic, psychosocial factors and rural-urban migration in treatment-seeking; and (3) prevalence and severity of SUDs, common comorbid psychiatric disorders and associated factors.

We will conduct an audit of all treatment services catering for men with SUDs in three study sites (in Khayelitsha an audit is already completed). In each service one respondent (manager) will be interviewed about the services provided. The role of culture in men's treatment-seeking will be explored via 32 in-depth interviews (8 per site) and 8 focus groups (2 per site) among men with SUDs, and IDIs with 24 SUDs treatment providers. Thematic analysis will identify cultural and other factors affecting treatment seeking dynamics. The prevalence and severity of SUDs and associated comorbidity and risk factors will be assessed via a household survey in Year 2 (in the Western Cape, Eastern Cape and North West provinces) using cluster random sampling, targeting 547 adult men18 years and above. We will also conduct a community survey in Soshanguve using Respondent Driven Sampling in Year 3 to estimate prevalence of nyaope use. Recruitment will involve multiple waves until the recommended sample of 350 users is reached. Findings will be presented to community stakeholders and key decision makers to propose interventions to improve treatment access, informed by all key cultural, economic and psychosocial factors.

Planned Impact

This project's focus on cultural factors as an obstacle to access to treatment services for men with substance use disorders (SUDs) will generate new understandings of relevance to the design of services. We will translate these findings through (a) involving key stakeholders as advisors from the outset of the project, which will enable ongoing dialogue; (b) hosting annual public engagements about the findings of the project targeting policy-makers, communities and the research community; (c) targeted engagements with policy-makers in the parliamentary portfolio committee on health; and (d) producing materials that translate the findings into understandable messages directed to communities, civil society and policy makers.

Through dissemination and engagement, we anticipate stronger civil society action and attention to the need for better treatment, and greater responsiveness from policy makers when presented with evidence. The forthcoming National Health Insurance (NHI) Bill in South Africa will provide additional opportunities to ensure that appropriate services are provided within the packages of care in the NHI through the process of public submissions on the Bill.

Lastly, research capacity will be built through research training opportunities on the project for a range of postgraduate students, supervised by experts from participating institutions. The project seminars will share research expertise amongst institutions which will, along with the findings of the project, be incorporated into training programmes in public health across the country, thereby building the capacity of human resources to address the problems of SUDs in South Africa.

Publications

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Mzombwe M (2019) The ethical imperative to treat NCDs during research in Africa. in The Lancet. Global health

 
Description This study showed that alcohol use disorders and use of other substances was common among men in 3 provinces in South Africa. We also found many men did not seek treatment services although they knew the services were available in their communities. This suggests that treatment seeking is an issue which needs to be addressed.
Exploitation Route We are planning engagement meetings with policy makers and also create policy briefs which will be available to those interested to take this forward
Sectors Communities and Social Services/Policy,Healthcare

 
Title Computer server 
Description We have purchased new computer server for storage of data collected in studies. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact We have now additional computer space to store data collected in our studies. 
 
Title Data served access 
Description We have developed capacity to transfer data remotely from a site to our servers. 
Type Of Material Improvements to research infrastructure 
Year Produced 2022 
Provided To Others? No  
Impact This has allowed our staff working in remote areas to transmit data directly to our facilities in Mwanza 
 
Title Improvement of online data storage facilities 
Description We have purchased a new computer server allowing for more space to store data from various studies. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact This have allowed studies to store data on secure data. Also allows staff to work from home and access files on the server. 
 
Title Introduced use of OpenClinica for data management 
Description This is an open source and GCP-compliant data management system which was introduced in all our studies in 2010 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact This system have helped to standardise data management systems across our studies 
 
Title Laboratory facility improvements 
Description We have expanded our laboratory facilities by developing a new laboratory sample archive unit, biosafety level 3 laboratory, and development of capacity for isolation and preservation of peripheral blood mononuclear cells, and HIV viral genotyping 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Improved laboratory infrastructure have allowed to expansion of the range of research studies conducted at our centre 
 
Title New lab techniques introduced for studying vaginal microbiome 
Description New lab techniques have been developed to study vaginal flora and how this influences the risk of HIV 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This have helped us to work in this new area of work to identify the role of vaginal microbiome in HIV transmission. 
 
Title Use of GPS for sampling study communities 
Description We have used GPS to sample areas within the communities in a population survey. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This allowed us to draw random sample of households in a large community-based survey where listing of households was not available. 
 
Title Use of android tablets for data collection 
Description We have purchased android tablets which will be used in collecting data in a large clinical trial we are conducting in Tanzania 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact We expect this system will allow us to collect more accurate data and contribute in more timely data analysis 
 
Title Use of electronic devices in collecting data 
Description We programmed PDAs to collect data in our large population survey 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This helped our team to collect more accurate data and minimise time required to clean the data after the survey 
 
Description Centre for Poverty-Related Communicable Diseases 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Technical support (epidemiology and biostatistics)
Collaborator Contribution Monitoring of clinical trials; data management expertise; ethical and regulatory requirements advice
Impact Strengthening research capacity in East African region.
 
Description Collaboration with Cornell University Medical Centre 
Organisation Cornell University
Department Weill Cornell Medicine
Country United States 
Sector Academic/University 
PI Contribution We have established a research collaboration and have two NIH funded collaborative projects
Collaborator Contribution Cornell University have developed research capacity on areas of chronic diseases and how this is related to HIV
Impact We have two grants funded by NIH as part of this collaboration
Start Year 2017
 
Description Collaboration with South African Medical Research Council 
Organisation Medical Research Council of South Africa (MRC)
Country South Africa 
Sector Public 
PI Contribution We applied for research funding as part of the South African and UK Mental Health research scheme
Collaborator Contribution South African MRC contributed funds for this project and we collaborated with senior scientists at this institution in developing the proposal.
Impact No outputs at this point
Start Year 2018
 
Description Institute of Tropical Medicine 
Organisation University of Liverpool
Department Institute of Translational Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Grant holder for EDCTP grant: Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa.
Collaborator Contribution Oversight and coordination of project
Impact Project currently in progress
Start Year 2012
 
Description International Center for Reproductive Health (ICRH), Mombasa 
Organisation International Center for Reproductive Health (ICRH)
Country Belgium 
Sector Charity/Non Profit 
PI Contribution Providing biostatistical expertise and training.
Collaborator Contribution Coordinate an EDCTP-funded project: Characterisation of novel microbicide safety biomarkers in East and South Africa
Impact Strengthening research capacity in Africa.
Start Year 2009
 
Description Kenya Medical Research Institute 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya 
Sector Public 
PI Contribution Provided contributions as part of the Lake Victoria Health Research Consortium
Collaborator Contribution Contributed in development of research agenda for the Lake Victoria Health Research Consortium
Impact We are working together in developing new proposals for funding
Start Year 2013
 
Description Kilimanjaro Christian Medical Centre (KCMC) 
Organisation Kilimanjaro Christian Medical Centre (KCMS)
Country Tanzania, United Republic of 
Sector Hospitals 
PI Contribution Coordinated an EDCTP-funded project: Capacity development and strengthening in preparation for HIV vaccine trials in Tanzania and Burkina Faso
Collaborator Contribution Research expertise: distribution of viral genotypes among high-risk and general populations; Role of co-morbidities in HIV pathogenesis and clinical course of HIV disease; Models of delivering care and treatment for people living with HIV/AIDS
Impact Strengthening research capacity in Africa.
Start Year 2008
 
Description Lake Victoria Consortium for Health Research 
Organisation International AIDS Vaccine Initiative (IAVI)
Country Global 
Sector Charity/Non Profit 
PI Contribution We have been working together to develop proposals to seek funding to study the epidemiology of HIV among fishing communities in East Africa. We hope to develop interventions with will be evaluated in Kenya, Tanzania and Uganda. We have applied for funding in the PHIND scheme to do formative work in preparation for a larger grant.
Collaborator Contribution Our partners have been working in developing proposals and also in conference calls and face to face meetings.
Impact So far the main output have been development and submission of the PHIND proposal which is under review. This is a multi-disciplinary team comprised of epidemiologists, social scientists, and laboratory scientists
Start Year 2013
 
Description Lake Victoria Consortium for Health Research 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya 
Sector Public 
PI Contribution We have been working together to develop proposals to seek funding to study the epidemiology of HIV among fishing communities in East Africa. We hope to develop interventions with will be evaluated in Kenya, Tanzania and Uganda. We have applied for funding in the PHIND scheme to do formative work in preparation for a larger grant.
Collaborator Contribution Our partners have been working in developing proposals and also in conference calls and face to face meetings.
Impact So far the main output have been development and submission of the PHIND proposal which is under review. This is a multi-disciplinary team comprised of epidemiologists, social scientists, and laboratory scientists
Start Year 2013
 
Description Lake Victoria Consortium for Health Research 
Organisation Medical Research Council (MRC)
Department MRC/UVRI and LSHTM Research Unit Uganda
Country Uganda 
Sector Academic/University 
PI Contribution We have been working together to develop proposals to seek funding to study the epidemiology of HIV among fishing communities in East Africa. We hope to develop interventions with will be evaluated in Kenya, Tanzania and Uganda. We have applied for funding in the PHIND scheme to do formative work in preparation for a larger grant.
Collaborator Contribution Our partners have been working in developing proposals and also in conference calls and face to face meetings.
Impact So far the main output have been development and submission of the PHIND proposal which is under review. This is a multi-disciplinary team comprised of epidemiologists, social scientists, and laboratory scientists
Start Year 2013
 
Description MRC Clinical Trials Unit 
Organisation Medical Research Council (MRC)
Department MRC Clinical Trials Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Technical support (epidemiology and biostatistics)
Collaborator Contribution Monitoring of clinical trials; data management expertise; ethical and regulatory requirement advice.
Impact Strenghtening research capacity in East African region.
 
Description MRC/UVRI Uganda Research Unit on AIDS 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda 
Sector Public 
PI Contribution Technical support (epidemiology and biostatistics)
Collaborator Contribution Provided experience in Phase I/II clinical trials; colposcopy expertise; lab expertise; financial and administrative capacity building support
Impact Strengthening research capacity in East African region
 
Description Muhimbili University College of Health and Allied Sciences 
Organisation Muhimbili University of Health and Allied Sciences
Country Tanzania, United Republic of 
Sector Academic/University 
PI Contribution We have collaborated with this institution in organising a conference for non-communicable diseases in Tanzania
Collaborator Contribution This institution hosted this conference and helped MITU to participate in developing the scientific agenda
Impact The conference was highly successful
Start Year 2021
 
Description Research project to develop intervention to reduce harmful alcohol use 
Organisation Medical Research Council of South Africa (MRC)
Country South Africa 
Sector Public 
PI Contribution We have developed a proposal funded by MRC as part of the PHIND scheme
Collaborator Contribution Our partner was involved in development of the proposal and now in its implementation after being funded by the MRC
Impact So far no outputs from this collaboration
Start Year 2017
 
Description St Augustine University 
Organisation St. Augustine University of Tanzania
Country Tanzania, United Republic of 
Sector Academic/University 
PI Contribution We have provided training and ongoing support of junior staff members of this institution.
Collaborator Contribution University of Dodoma has visited our institution and contributed in providing clinical support for our research team
Impact Exchange visits and working together on training programme
Start Year 2019
 
Description Tanzania Alcohol Prevention Association 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Research Centre (MRC)
Country Tanzania, United Republic of 
Sector Academic/University 
PI Contribution We have worked with this organization to reach policy makers in Tanzania
Collaborator Contribution This collaborator have helped to arrange meetings with key policy makers in Tanzania
Impact We have held 3 meetings with high level government officials
Start Year 2022
 
Description Tanzania Diabetes Association 
Organisation St Francis Hospital, Tanzania
Country Tanzania, United Republic of 
Sector Hospitals 
PI Contribution I contributed in a proposal to seek for funding to explore NCDs in cities
Collaborator Contribution They provided training of our staff in MITU
Impact Not yet
Start Year 2022
 
Description University of Johannesburg 
Organisation University of Johannesburg
Country South Africa 
Sector Academic/University 
PI Contribution We are working with University of Johannesburg in a new MRC funded project
Collaborator Contribution We have a subcontract for this grant coming through this institution
Impact None at this time
Start Year 2019
 
Description University of Montpellier, France 
Organisation University of Montpellier
Department Laboratory of Bacteriology and Virology Montpellier
Country France 
Sector Academic/University 
PI Contribution Coordinated an EDCTP-funded project: Capacity development and strengthening in preparation for HIV vaccine trials in Tanzania and Burkina Faso
Collaborator Contribution Providing technical support in the area of laboratory capacity building and conducting proposed laboratory assays
Impact Strengthening research capacity in Africa
Start Year 2008
 
Description University of Ouagadougou, Burkina Faso 
Organisation University of Ouagadougou
Country Burkina Faso 
Sector Academic/University 
PI Contribution Coordinated an EDCTP-funded project: Capacity development and strengthening in preparation for HIV vaccine trials in Tanzania and Burkina Faso
Collaborator Contribution Providing south-south capacity building and exchange of technical expertise with Africian collaborators
Impact Strengthening research capacity in Africa.
Start Year 2008
 
Description Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was a poster presentation at a conference in South Africa
Year(s) Of Engagement Activity 2019
 
Description Dissemination of EDCTP Women's Health Project results to participants 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact We conducted 3 workshops (each attended by about 38 people) to provide results of this study to study participants and also health workers at 3 field sites in northern Tanzania.

These workshops helped participants to know the key findings from this research and raise awareness about factors associated with HIV in this part of Tanzania
Year(s) Of Engagement Activity 2010
 
Description Dissemination workshop (MDP 301 Trial) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact We had 45 people attending and who were very engaged during the workshop

No notable impact
Year(s) Of Engagement Activity 2010
 
Description Interview for national news 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview after the workshop
Year(s) Of Engagement Activity 2019
 
Description Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact This meeting was to review preliminary results of our study
Year(s) Of Engagement Activity 2023
 
Description Meeting in Dar es Salaam, Tanzania 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This meeting was organised to present results of a formative research on heterosexual anal sex. Was attended by 55 policy makers and scientists

This meeting generated interest in this topic and future studies are being planned
Year(s) Of Engagement Activity 2013
 
Description Meeting with Tanzania Ministry of Health officials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This meeting was attended by 40 policy makers. Preliminary results of MRC-funded chronic diseases project were presented and discussed.

This meeting helped to highlight the importance of chronic diseases in Tanzania
Year(s) Of Engagement Activity 2013
 
Description Meeting with key stakeholders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact This meeting was designed to provide information about research studiues implemented by my group in Tanzania
Year(s) Of Engagement Activity 2018
 
Description Meeting with policy makers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This meeting was held at the Ministry of Health in Dar es Salaam to discuss findings of our health systems project and plan intervention phase. The presentation involved lively discussions and helpful input was obtained.

After this meeting we were invited to be part of the chronic diseases working group in Tanzania.
Year(s) Of Engagement Activity 2014
 
Description Open day and exhibition 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact About 150 people attended the open day and were engaged

None
Year(s) Of Engagement Activity 2012
 
Description Scientific conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was a scientific conference on HIV-related research. We presented findings from our research to about 80 people in attendance
Year(s) Of Engagement Activity 2021
 
Description Visited Harvard School of Public Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This presentation was attended by 35 academic colleagues at Harvard

I presented research studies implemented by Mwanza Intervention Trials Unit and opportunities for possible collaboration in the future was discussed.
Year(s) Of Engagement Activity 2013
 
Description Website posting 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was an article describing our work in Mwanza, Tanzania.
Year(s) Of Engagement Activity 2019
 
Description Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 45 people attended information meeting
Year(s) Of Engagement Activity 2022
 
Description Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This workshop was aimed to disseminate results of our study aimed to improve health system respond to non-communicable diseases in public institutions in Tanzania.
Year(s) Of Engagement Activity 2017
 
Description Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact This workshop reviewed policies related to alcohol use in Tanzania
Year(s) Of Engagement Activity 2018
 
Description Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 45 people attended information meeting
Year(s) Of Engagement Activity 2022
 
Description Workshop with community members 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact This meeting aimed to update members of the community about the research we are conducting
Year(s) Of Engagement Activity 2020