Causes, Consequences and Modification of Health Behaviour
Lead Research Organisation:
University of Bristol
Department Name: UNLISTED
Abstract
Health behaviours – smoking, drinking, diet and so on – re important influences on both physical and mental health. This programme attempts to understand how these behaviours impact on our health, and how they influence each other. This understanding will help to identify ways in which we can promote healthier behaviour, for example by helping people to stop smoking or reduce their drinking.
Technical Summary
The overarching aim of this programme is to understand relationships between health behaviours and both physical and mental health outcomes, in order to develop a better understanding of the mechanistic pathways that underline these relationships and identify targets for novel individual and population level interventions.
Our specific aims include:
- To identify novel genetic instruments relevant to health behaviours for use in Mendelian randomisation (MR) analyses.
- To understand the network of causal relationships between health behaviours and a range of physical and mental health outcomes.
- To interrogate the mechanistic pathways that underlie causal relationships between behaviour and health and identify targets for intervention.
This programme will provide a flow of work that will provide mechanistic insight into causal relationships between health behaviours and both physical and mental health outcomes, and support subsequent intervention development and testing, through existing relationships with other major research groupings and industry partners.
Our specific aims include:
- To identify novel genetic instruments relevant to health behaviours for use in Mendelian randomisation (MR) analyses.
- To understand the network of causal relationships between health behaviours and a range of physical and mental health outcomes.
- To interrogate the mechanistic pathways that underlie causal relationships between behaviour and health and identify targets for intervention.
This programme will provide a flow of work that will provide mechanistic insight into causal relationships between health behaviours and both physical and mental health outcomes, and support subsequent intervention development and testing, through existing relationships with other major research groupings and industry partners.
People |
ORCID iD |
Marcus Munafo (Principal Investigator) |
Publications
Richmond RC
(2021)
Investigating the DNA methylation profile of e-cigarette use.
in Clinical epigenetics
Ronkainen J
(2022)
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium.
in Epigenetics
Sallis H
(2019)
F126INVESTIGATING THE ASSOCIATION BETWEEN GENETIC LIABILITY FOR SCHIZOPHRENIA AND CHILDHOOD TRAUMA
in European Neuropsychopharmacology
Sallis H
(2019)
SMOKING AND NEUROTICISM: USING MENDELIAN RANDOMIZATION TO INVESTIGATE CAUSALITY
in European Neuropsychopharmacology
Sallis H
(2020)
Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood
in Psychological Medicine
Sallis H
(2018)
Correction to 'Genetics of biologically based psychological differences'.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Sallis H
(2019)
General psychopathology, internalising and externalising in children and functional outcomes in late adolescence.
in Journal of child psychology and psychiatry, and allied disciplines
Sallis H
(2018)
Genetics of biologically based psychological differences.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Sallis HM
(2023)
Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health.
in International journal of epidemiology
Sallis HM
(2019)
Cigarette smoking and personality: interrogating causality using Mendelian randomisation.
in Psychological medicine
Sallis HM
(2023)
Using allele scores to identify confounding by reverse causation: studies of alcohol consumption as an exemplar.
in International journal of epidemiology
Sampaio C
(2019)
Reader response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease.
in Neurology
Sanderson E
(2022)
Mendelian randomization.
in Nature reviews. Methods primers
Sanderson E
(2019)
Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour.
in Nature communications
Sillero-Rejon C
(2018)
Alcohol pictorial health warning labels: the impact of self-affirmation and health warning severity.
in BMC public health
Skaaby T
(2022)
Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis.
in European journal of epidemiology
Skaaby T
(2018)
Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis.
in European journal of clinical nutrition
Skaaby T
(2019)
Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis.
in Addiction (Abingdon, England)
Skinner AL
(2018)
Evaluating clinical stop-smoking services globally: towards a minimum data set.
in Addiction (Abingdon, England)
Skinner AL
(2019)
StopWatch: The Preliminary Evaluation of a Smartwatch-Based System for Passive Detection of Cigarette Smoking.
in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Skrivankova VW
(2021)
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration.
in BMJ (Clinical research ed.)
Slaney C
(2023)
Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses
in Brain, Behavior, and Immunity
Suddell S
(2023)
Emotional bias training as a treatment for anxiety and depression: evidence from experimental medicine studies in healthy and medicated samples.
in Psychological medicine
Taylor AE
(2018)
Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.
in International journal of epidemiology
Taylor AE
(2018)
Associations of coffee genetic risk scores with consumption of coffee, tea and other beverages in the UK Biobank.
in Addiction (Abingdon, England)
Taylor AE
(2019)
The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.
in Human molecular genetics
Taylor GMJ
(2019)
Does smoking cause poor mental health?
in The lancet. Psychiatry
Taylor GMJ
(2020)
Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders.
in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Taylor GMJ
(2021)
Addressing concerns about smoking cessation and mental health: theoretical review and practical guide for healthcare professionals.
in BJPsych advances
Taylor M
(2018)
Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts.
in International journal of epidemiology
Thelwall M
(2020)
Is useful research data usually shared? An investigation of genome-wide association study summary statistics.
in PloS one
Thibault RT
(2020)
Commentary: Improving our statistical inferences requires meta-research.
in International journal of epidemiology
Thomas KH
(2022)
Comparative clinical effectiveness and safety of tobacco cessation pharmacotherapies and electronic cigarettes: a systematic review and network meta-analysis of randomized controlled trials.
in Addiction (Abingdon, England)
Thomas KH
(2021)
Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis.
in Health technology assessment (Winchester, England)
Tielbeek JJ
(2022)
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.
in Molecular psychiatry
Toumpakari Z
(2019)
Cardiometabolic Risk Factors and Physical Activity Patterns Maximizing Fitness and Minimizing Fatness Variation in Malaysian Adolescents: A Novel Application of Reduced Rank Regression.
in International journal of environmental research and public health
Treur J
(2019)
SA138INVESTIGATING BI-DIRECTIONAL, CAUSAL EFFECTS BETWEEN SUBSTANCE USE AND ADHD
in European Neuropsychopharmacology
Treur J
(2021)
Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review
in Psychological Medicine
Treur JL
(2018)
Investigating genetic correlations and causal effects between caffeine consumption and sleep behaviours.
in Journal of sleep research
Treur JL
(2018)
Commentary on Kristjansson et al. (2018): Caffeine use during early adolescence as a possible risk factor for initiation of smoking and alcohol use.
in Addiction (Abingdon, England)
Related Projects
Project Reference | Relationship | Related To | Start | End | Award Value |
---|---|---|---|---|---|
MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £2,864,000 | ||
MC_UU_00011/2 | Transfer | MC_UU_00011/1 | 01/04/2018 | 31/03/2023 | £965,000 |
MC_UU_00011/3 | Transfer | MC_UU_00011/2 | 01/04/2018 | 31/03/2023 | £1,011,000 |
MC_UU_00011/4 | Transfer | MC_UU_00011/3 | 01/04/2018 | 31/03/2023 | £1,329,000 |
MC_UU_00011/5 | Transfer | MC_UU_00011/4 | 01/04/2018 | 31/03/2023 | £1,254,000 |
MC_UU_00011/6 | Transfer | MC_UU_00011/5 | 01/04/2018 | 31/03/2023 | £1,640,000 |
MC_UU_00011/7 | Transfer | MC_UU_00011/6 | 01/04/2018 | 31/03/2023 | £1,083,000 |
Description | Collaborative Award |
Amount | £3,123,724 (GBP) |
Funding ID | 206853/Z/17/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2018 |
End | 12/2021 |
Description | Confidence in Global Mental Health Research |
Amount | £173,000 (GBP) |
Funding ID | MC_PC_MR/R019622/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 02/2019 |
Description | PHIND |
Amount | £149,993 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2018 |
End | 10/2020 |
Description | Registered Reports Funding: A pilot and feasibility study |
Amount | £59,605 (GBP) |
Funding ID | 214528 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2018 |
End | 09/2019 |
Description | fMRI investigation of the neural mechanisms of Emotional Cognitive Bias Modification as an adjunct therapy to SSRIs in depression. |
Amount | £504,133 (GBP) |
Funding ID | MR/S035648/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2020 |
End | 12/2024 |
Description | AstraZeneca Postdoctoral Fellowship |
Organisation | AstraZeneca |
Country | United Kingdom |
Sector | Private |
PI Contribution | We are exploring the role of genetic variation in smoking behaviour, using recall-by-genotype and human laboratory designs. |
Collaborator Contribution | AstraZeneca have provided a postdoctoral research fellow on secondment to my group, and consumables funding, to support this project. This was extended by 1 years to investigate patterns of smoking behaviour in COPD patients. |
Impact | None yet. |
Start Year | 2015 |
Description | BBC Inside Health |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interview on BBC Inside Health discussing the polarisation of the debate on e-cigarettes for tobacco harm reduction. |
Year(s) Of Engagement Activity | 2019 |
Description | Bristol Take Drugs Seriously |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Organised in collaboration with Transform Drug Policy Foundation and the University of the West of England. Main event held in Colston Hall on 23 January 2020 - exhibition, guest lecture (David Nutt) and panel debate. Other events held across week including book launch. |
Year(s) Of Engagement Activity | 2020 |
Description | Creative Reactions |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Creative Reactions - a collaboration between artists and scientists, resulting in artworks depicting ongoing research activity. |
Year(s) Of Engagement Activity | 2018,2019 |
Description | Green Man Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Stall in Einstein's Garden at Green Man Festival, with a number of activities demonstrating research conducted. |
Year(s) Of Engagement Activity | 2019 |
Description | It Takes a Village |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | Showcasing research to professional services staff across the University of Bristol to highlight / recognise their contributions to the research process. |
Year(s) Of Engagement Activity | 2022 |
Description | Take Drugs Seriously |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | We brought together academics, service providers, practitioners, policy makers and political party groups in Colston Hall to promote conversation on drugs and drug policy and to demonstrate the amount of work that is being achieved in the city. The event comprised of an exhibition, followed by a talk from the former Chair of the Advisory Council on the Misuse of Drugs, Professor David Nutt, and a panel debate including Professor Nutt, the deputy mayor of Bristol, Cllr Asher Craig, the CEO of Bristol Drugs Project Maggie Telfer, and the Anyone's Child Activist Cara Lavan. |
Year(s) Of Engagement Activity | 2020 |
URL | https://transformdrugs.org/blog/bristol-take-drugs-seriously |