ADIPOSE TISSUE DYSFUNCTION AND LIPOTOXICITY
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
Obesity is associated with insulin resistance, diabetes and cardiovascular problems. We want to know why and how obesity causes these problems and what can be done to either prevent or reverse it. For this purpose, we will investigate the molecular links between this cluster of pathologies. We think that one of the mechanisms that links obesity to other metabolic diseases is related to the impaired capacity of the adipose tissue (fat) to expand and function, causing it to release toxic lipid species that accumulate and affect other organs such as pancreas, liver and skeletal muscle.
Specifically we aim to: a) understand the normal mechanisms enabling the adipose tissue to grow in a “healthy” way that does not result in the metabolic problems typically associated with obesity, such as diabetes and heart attacks; b) define whether targeting brown adipose tissue, a type of fat that uses fat to make heat, can prevent or reverse obesity and its associated diseases; and c) identify diagnostic biomarkers to identify the risk of developing complications as well as pathogenic therapeutically targetable mechanisms. For this purpose, we will use mouse models and cells, advanced experimental studies and technologies to validate our most significant findings before working with our collaborators to confirm them in humans.
Specifically we aim to: a) understand the normal mechanisms enabling the adipose tissue to grow in a “healthy” way that does not result in the metabolic problems typically associated with obesity, such as diabetes and heart attacks; b) define whether targeting brown adipose tissue, a type of fat that uses fat to make heat, can prevent or reverse obesity and its associated diseases; and c) identify diagnostic biomarkers to identify the risk of developing complications as well as pathogenic therapeutically targetable mechanisms. For this purpose, we will use mouse models and cells, advanced experimental studies and technologies to validate our most significant findings before working with our collaborators to confirm them in humans.
Technical Summary
This programme aims to identify the molecular mechanisms that link obesity with its metabolic complications. Our approach is adipocentric, focusing on adipose tissue expandability and function as main determinants of the pathophysiological link, and the contribution of quantitative and qualitative lipotoxic-related mechanisms.
We aim to:
a) establish the molecular mechanisms controlling adipose tissue plasticity as a strategy to prevent the development of obesity-associated metabolic complications
b) define the anti-lipotoxic effects of oxidative pathways through strategies that promote mitochondrial oxidation in brown adipose tissue thermogenesis as well as to identify futile, energy costly, cellular and molecular strategies to increase energy expenditure (e.g muscle thermogenesis)
c) identify biomarkers of prognostic, diagnostic and therapeutic value based on 1) specific lipid species or group of lipids associated with lipotoxicity and 2) targeted genes, pathways and molecules that promote energy dissipation.
These objectives will be addressed through a multidisciplinary approach involving genetically engineered murine, fish and fly models, state-of-the-art in vivo and in vitro phenotyping, and systems-biology approaches such as RNAseq, lipidomics and metabolomics technologies, integrated bioinformatics platforms. Finally, we intend to work with our collaborators to validate those findings/candidate targets in human translational studies.
We aim to:
a) establish the molecular mechanisms controlling adipose tissue plasticity as a strategy to prevent the development of obesity-associated metabolic complications
b) define the anti-lipotoxic effects of oxidative pathways through strategies that promote mitochondrial oxidation in brown adipose tissue thermogenesis as well as to identify futile, energy costly, cellular and molecular strategies to increase energy expenditure (e.g muscle thermogenesis)
c) identify biomarkers of prognostic, diagnostic and therapeutic value based on 1) specific lipid species or group of lipids associated with lipotoxicity and 2) targeted genes, pathways and molecules that promote energy dissipation.
These objectives will be addressed through a multidisciplinary approach involving genetically engineered murine, fish and fly models, state-of-the-art in vivo and in vitro phenotyping, and systems-biology approaches such as RNAseq, lipidomics and metabolomics technologies, integrated bioinformatics platforms. Finally, we intend to work with our collaborators to validate those findings/candidate targets in human translational studies.
Organisations
- University of Cambridge (Lead Research Organisation)
- Rey Juan Carlos University Hospital (Collaboration)
- Newcastle University (Collaboration)
- Nanjing University (NJU) (Collaboration)
- Chiba University (Collaboration)
- British Heart Foundation (BHF) (Collaboration)
- Microsoft Research (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France (Collaboration)
- Uppsala University (Collaboration)
- German Cancer Research Center (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Model Animal Research Center (MARC) Nanjing (Collaboration)
- University of Barcelona (Collaboration)
- European Commission (Collaboration)
People |
ORCID iD |
Publications
Agrawal M
(2019)
Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Araiz C
(2020)
Publisher Correction: Enhanced ß-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110a inactivation in adipose tissue.
in Nature communications
Araiz C
(2019)
Enhanced ß-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110a inactivation in adipose tissue.
in Nature communications
Arias De La Rosa I
(2018)
Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.
in Journal of internal medicine
Artero Castro A
(2019)
Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.
in Stem cell research
Azzu V
(2021)
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
in Molecular Metabolism
Azzu V
(2020)
Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease.
in Gastroenterology
Badenes M
(2020)
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.
in Molecular metabolism
Baig S
(2020)
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
in BMJ open diabetes research & care
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| MC_UU_00014/1 | 01/04/2018 | 31/03/2024 | £2,995,583 | ||
| MC_UU_00014/2 | Transfer | MC_UU_00014/1 | 01/04/2018 | 31/03/2024 | £2,871,979 |
| MC_UU_00014/3 | Transfer | MC_UU_00014/2 | 01/04/2018 | 31/03/2024 | £1,667,444 |
| MC_UU_00014/4 | Transfer | MC_UU_00014/3 | 01/04/2018 | 31/03/2024 | £1,743,788 |
| MC_UU_00014/5 | Transfer | MC_UU_00014/4 | 01/04/2018 | 31/03/2024 | £3,355,490 |
| MC_UU_00014/6 | Transfer | MC_UU_00014/5 | 01/04/2018 | 31/03/2024 | £1,325,715 |
| Title | Development of new webb for the TVP lab |
| Description | tvp.mrl.ims.cam.ac.uk/ |
| Type Of Art | Creative Writing |
| Year Produced | 2013 |
| Impact | Much broader reach attracting more visitors |
| URL | http://www.tvp.mrl.ims.cam.ac.uk/ |
| Title | TVPLAB twitter |
| Description | Use of Social Media TVPLAB TWITTER https://twitter.com/tvplab?lang=en-gb |
| Type Of Art | Creative Writing |
| Year Produced | 2015 |
| Impact | Creative tool to communicate our science to public |
| URL | https://twitter.com/tvplab?lang=en-gb |
| Description | Barcelona, Spain. 05th -07th June 2019. Cardiovascular and Metabolic diseases Expert Selection Committee - La Caixa Foundation |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Barcelona, Spain. 05th -07th June 2019. Cardiovascular and Metabolic diseases Expert Selection Committee - La Caixa Foundation Interview of candidates awards CAIXA |
| URL | https://obrasociallacaixa.org/en/investigacion-y-becas/convocatorias-de-investigacion/convocatoria-d... |
| Description | Barcelona, Spain. 27th November 2019. External Scientific Council meeting, Institut D'investigacions Blomediques Agust PI Sunyer (IDIBAPS) |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Barcelona, Spain. 27th November 2019. External Scientific Council meeting, Institut D'investigacions Blomediques Agust PI Sunyer (IDIBAPS) Defined strategic plan and funding allocation priorities at IDIBAPS research centre |
| URL | https://www.clinicbarcelona.org/en/idibaps/about-us/governing-bodies/idibaps |
| Description | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | 4. Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. Chair Panel selecting awardees ERC starting grant. Decision of science and work force |
| Description | Danish Diabetes Academy International Advisory Board |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Redefined the strategy for their objectives in education and training. |
| URL | https://www.danishdiabetesacademy.dk/about/organisational-structure/international-advisory-board |
| Description | London, UK. 13th November 2019. Medical Research Council Leaders Conference 2019 |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | London, UK. 13th November 2019. Medical Research Council Leaders Conference 2019 Meeting for dissemination of MRC strategic plans and advisory |
| Description | Valencia, Spain. 28th-29th November 2019. Instituto de Investigacion Sanitaria (INCLIVA) |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | 2. Valencia, Spain. 28th-29th November 2019. Instituto de Investigacion Sanitaria (INCLIVA) Defined strategic plan and budget allocation of activities of INCLIVA research centre |
| URL | https://www.incliva.es/comite-cientifico-externo |
| Description | • External Advisory Board: Rodent Metabolic Phenotyping Platform of the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen (2022-) |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Rodent Metabolic Phenotyping Platform strategy and quality control |
| URL | https://cbmr.ku.dk/researchfacilities/rodent-metabolic-phenotyping-platform/ |
| Description | • External Scientific Committee Health Research Institute of Santiago de Compostela (IDIS) (2022-) |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | • External Scientific Committee Health Research Institute of Santiago de Compostela (IDIS) (2022-) This is a role as scientific advisory board of research Institute |
| URL | https://www.idisantiago.es/en/organization/#training-committee |
| Description | • External Scientific Committee Novo Nordisk Foundation Center for Basic Metabolic Research |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Advisory board on scientific strategy and management |
| URL | https://cbmr.ku.dk/about/scientific-advisory-board/ |
| Description | Academy of Medical Sciences Clinical Lecturer Starter Grant (30,000) |
| Amount | £30,000 (GBP) |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2019 |
| Description | Litmus IMI |
| Amount | € 16,000,000 (EUR) |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2018 |
| End | 12/2022 |
| Description | Mason Medical Research Grant (15,000) |
| Amount | £15,000 (GBP) |
| Organisation | Mason Medical Research Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | Programme grant |
| Amount | £1,245,413 (GBP) |
| Funding ID | RG/18/7/33636 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2023 |
| Description | targetting macrophage lipid metabolism |
| Amount | £1,255,413 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2023 |
| Title | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state |
| Description | Combining Stable Isotopes with calorimetry to investigate free-living nutrient utilisation in the fed state This is an improvement in the methodology that allows us to study insulin sensitivity without radioactivity in animals that are not sedated and recapitulate more physiological conditions. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. Epub 2018 May 16. |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/29789270 |
| Title | Metabolic phenotyping technology |
| Description | Systems of administration of lipids in vivo as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Systems for controlled administration of lipids as a controlled system to study lipotoxicity D20 to measure fatty acid synthesis in livers of mice. Both approaches are very useful to investigate the effects and localisation of specific fatty acids in vivo as well as their routes of metabolisation. This allowed dynamic studies of fluxes of lipids. |
| Title | Stem cell protocol to differentiate BAT |
| Description | Stem cell protocol to differentiate BAT |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | This is a unique tool to differentiate in vitro human brown fat, overcoming a limited resource and providing a model for therapeutic developmenst |
| URL | https://pubmed.ncbi.nlm.nih.gov/33606988/ |
| Description | Chiba University |
| Organisation | Chiba University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Technology and animal models |
| Collaborator Contribution | Salary support for postdoctoral fellow |
| Impact | 1. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PMID: 31509948 Free PMC Article Similar articles Select item 26615883 2.Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565. PMID: 26615883 Free PMC Article Similar articles Select item 26584636 3.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. Lee E, Korf H, Vidal-Puig A. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. |
| Start Year | 2018 |
| Description | Collaboration with University Rey Juan carlos Madrid. |
| Organisation | Rey Juan Carlos University Hospital |
| Country | Spain |
| Sector | Hospitals |
| PI Contribution | Provided animal models to study Kidney lipotoxicity |
| Collaborator Contribution | Provided expertise in murine characterisation of kidney phenotypes. Provide expertise in murine metabolic phenotyping |
| Impact | 1 Obesity and pregnancy, the perfect metabolic storm. Corrales P, Vidal-Puig A, Medina-Gómez G. Eur J Clin Nutr. 2021 Dec;75(12):1723-1734. doi: 10.1038/s41430-021-00914-5. Epub 2021 Apr 28. PMID: 33911209 Review. 2. Autocrine IGF2 programmes ß-cell plasticity under conditions of increased metabolic demand. Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M. Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID: 33833312 Free PMC article. 3. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. PLoS Genet. 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. eCollection 2020 Oct. PMID: 33057429 Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M. Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069. PMID: 30332637 Free Article 4.PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID: 30037087 Free PMC Article 5. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešic M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. PMID: 28683288 F |
| Start Year | 2019 |
| Description | FAtty Liver |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Country | Belgium |
| Sector | Public |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | FAtty Liver |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Murine studies to identify NASH biomarkers and molecular mechanisms of disease. Important input from the point of lipid metabolism in macrophages and signalling in Kupffer cells and stellate cells. |
| Collaborator Contribution | Newcastle: Leader 2020 Horizon Epoos and IMI Litmus. Access to human data EBI: Bioinformatic analysis - PhD Studetship |
| Impact | Funding 2020 Epoos and IMIM Litmus Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP.Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 23. doi: 10.1097/HEP.0000000000000341. Online ahead of print. PMID: 36811413 Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešic M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. eCollection 2022 Sep 16. PMID: 36065182 Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3:S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. Online ahead of print. PMID: 36740049 Free article. Review. 1. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473 2. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. ß2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547 3. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lup?or-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yilmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645 4. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi: 10.1016/j.jhep.2021.04.044. PMID: 33991635 5. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690 6. Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešic M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448.doi:10.1126/scitranslmed.aba4448. PMID: 33268509 7. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi: 10.1053/j.gastro.2019.12.054. [Epub ahead of print] PMID: 32061598 Similar articles Select item 27863448 8.Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Hepatology. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. Epub 2017 Feb 6. PMID: 27863448 Free PMC Article Similar articles Select item 26378642 9.Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Vacca M, Allison M, Griffin JL, Vidal-Puig A. Semin Liver Dis. 2015 Aug;35(3):250-61. doi: 10.1055/s-0035-1562945. Epub 2015 Sep 17. Review. PMID: 26378642 Similar articles |
| Start Year | 2016 |
| Description | Flies as a disease model to study metabolic disease |
| Organisation | German Cancer Research Center |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | provide hypothesis for validation in flies and also perform experiments in mammalian systems with insights coming from flies. |
| Collaborator Contribution | generation of genetically modified flies mimicking mouse or cell genetic modification. |
| Impact | Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015 Jul 27. doi: 10.1038/nature14601. Dietary stearic acid regulates mitochondria in vivo in humans. Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6. PMID: 30087348 Free PMC Article German Cancer Research Center (DKFZ) Serving as SAB of the |
| Start Year | 2015 |
| Description | Joint Unit CIPF-CAMBRIDGE Obesity and Metabolic Regulation |
| Organisation | Microsoft Research |
| Department | Microsoft Research Cambridge |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Genetic engineering of human pluripotent stem cells |
| Collaborator Contribution | Validation of Phenotyping of cells (CIPF). KAUST (AI Application to identify reposition of compounds) Microsoft Cambridge (Bioinformatic Analysis) Cite s |
| Impact | Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK. Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S. Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free Article Artero Castro A, Long K, Bassett A, Machuca C, León M, Ávila-Fernandez A, Cortón M, Vidal-Puig T, Ayuso C, Lukovic D, Erceg S.Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK Stem Cell Res. 2019 Jan;34:101341. doi: 10.1016/j.scr.2018.11.003. Epub 2018 Nov 16. PMID: 30612079 Free article. 2 Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A.Unraveling the developmental roadmap toward human brown adipose tissue. Stem Cell Reports. 2021 Feb 6:S2213-6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. Online ahead of print. PMID: 33606988 Free article.enetic engineering of Cell |
| Start Year | 2017 |
| Description | Macrophage |
| Organisation | British Heart Foundation (BHF) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | Macrophage |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Financial support for experiments and research expertise |
| Collaborator Contribution | Research Expertise in worm models of immune disease |
| Impact | Publication under review 1. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575 2. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599 4. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223 5. Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266.doi: 10.1096/fj.202001101R. PMID:33484195 |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Model Animal Research Center (MARC) Nanjing |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | NANJING/SUZHOU |
| Organisation | Nanjing University (NJU) |
| Country | China |
| Sector | Academic/University |
| PI Contribution | Provide expertise in murine metabolic phenotyping |
| Collaborator Contribution | Phenotyping of mice and PhD studentship |
| Impact | N/A • Prof. Antonio Vidal-Puig is a concurrent professor at Nanjing University appointed in September of 2017. • A joint lab focusing on non-alcoholic fatty liver disease has been established at MARC in 2017, co-headed by Profs. Antonio Vidal-Puig and Shuai Chen. • Strong collaborative links with professor Chen Yu Zhang at the Institute of Life Sciences of the University of Nanjing to identify mechanism of disease in metabolic disorders. CYZ is one of the leaders in the development of Biology AI 3.0 in Nanjing • Prof. Antonio Vidal-Puig visits Nanjing University at least twice a year and gives lectures. • A joint workshop on metabolic diseases is to be held in May of 2019 in Nanjing. Six scientists including Prof. Antonio Vidal-Puig from Cambridge and 15 scientists from Nanjing University will attend this workshop.Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Huang-Doran I, Zhang CY, Vidal-Puig A. Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2017 Jan;28(1):3-18. doi: 10.1016/j.tem.2016.10.003. Epub 2016 Oct 31. PMID: 27810172 Review. 2 Cite Share Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic ß cells control glucose homeostasis via the secretion of exosomal miR-29 family.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21. PMID: 33520119 Free PMC article. |
| Start Year | 2018 |
| Description | Obesity uncoupling |
| Organisation | Icahn School of Medicine at Mount Sinai |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Obesity uncoupling |
| Organisation | Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm, Paris, France |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Obesity uncoupling |
| Organisation | Uppsala University |
| Department | Department of Medical Sciences |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Stem cell work modelling human mutations |
| Collaborator Contribution | Identification of human mutants relevant in obesity and cardiometabolic complications (mount Sinai). Information related to adipose tissue molecular markers in humans (INSERM) Studies in fish prioritising mutants for subsequent studies in Stem cells. Study of Lymphocytes from human adipose tissue sequence information. |
| Impact | Multidisciplinary involving stem cell biology, genetic, zebra fish 2) NIH "Search for obesity-associated genes with protective effects on metabolic health"- Genes for healthy obesity. R01DK107786. 20 September 2017 - 30 June 2021. $415,896.05 3) Fellowship for a postdoctoral fellowship 4) Publication: Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22. PMID: 33619380 |
| Start Year | 2016 |
| Description | Univerisdad de Barcelona- |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provide genetically modified murine models and technological support for phenotyping |
| Collaborator Contribution | Specific knowledge in the analysis of CPT1 mutants. This is a very specific type of specialised knowledge that provides us with competitive advantage |
| Impact | 1. Allostatic hypermetabolic response in PGC1a/ß heterozygote mouse despite mitochondrial defects. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešic M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID: 34369602 2. P465L-PPAR? mutation confers partial resistance to the hypolipidaemic action of fibrates. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. Epub 2018 Jun 27. PMID: 29790245 Free PMC Article Similar articles Select item 26584636 Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951. PMID: 26584636 Free PMC Article Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. PMID: 25352638 Free Article Trends Pharmacol Sci. 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3. Pharmacological strategies for targeting BAT thermogenesis. Whittle A1, Relat-Pardo J, Vidal-Puig A. |
| Start Year | 2018 |
| Description | 2019: An interview with PhD student Jennie Leggat on CBBC - |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 2019: An interview with PhD student Jennie Leggat on CBBC - https://www.bbc.co.uk/iplayer/episode/m000cgln/operation-ouch-series-8-15-food-poo-and-you |
| Year(s) Of Engagement Activity | 2019 |
| Description | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | 1. London, UK. 10th -11th February 2020. 3rd Global nonalcoholic steatohepatitis (NASH) Congress and co-located 1st Metabolic Syndrome, Diabetes and nonalcoholic fatty liver disease (NAFLD) Congress London. Key meeting to engage with industry. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.global-engage.com/event/nash/ |
| Description | 2. Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 5th July 2019 Joint work shop by Cambridge University Nanjing Centre of Technology and Innovation, Institute Metabolic Science, University of Cambridge, Model Animals Research Centre (MARC), University of Nanjing. Meeting and networking event with colleagues from Cambridge and Nanjing to develop collaborative network |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2019: An educational video on diabetes from Senior Research Associate Sam Virtue |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2 019: An educational video on diabetes from Senior Research Associate Sam Virtue https://www.youtube.com/watch?v=YmgYhDHl55c&t=2s. https://www.youtube.com/watch?v=bYSXqTAJBOo&t=8s |
| Year(s) Of Engagement Activity | 2019 |
| Description | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 4. Bradford, UK. 1st December 2018. SRUK Seminar (Society of Spanish Researchers in the UK). |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.eventbrite.co.uk/e/v-christmas-seminar-science-of-healthy-diet-sports-wellbeing-tickets-... |
| Description | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 5. Valencia, Spain. 13th-15th November 2019 Spain Minisymposium Centro de Investigación Príncipe Felipe (CIPF). Longevity world forum, "Preclinical Models in Ageing and Metabolism Research" Global forum related to Ageing from a socio scientific and multicultural perspective. Open to lay public and highly advertised. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.longevityworldforum.com/tag/aging-2/ |
| Description | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 5. London, UK. 30th October 2018. California Walnut Commission Scientific & Health Research Meeting. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bighospitality.co.uk/News/Promotional-Features/California-Walnut-Culinary-Institute-of-A... |
| Description | 6. Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Colorado, USA. 31st March - 5th April 2019. Keystone Symposia on Lipidomics and Functional Metabolic Pathways in Disease. Conference at Keystone related to lipidomic analysis in the context of lipotoxicity |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://tks.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1595 |
| Description | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | 6. Sheffield, UK. 10th-11th September 2018. The British Society for Cardiovascular Research Autumn Meeting 'Inflammation and repair'. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://bscr.org/event/bscr-autumn-meeting-2018-inflammation-and-repair/ |
| Description | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Amsterdam, Netherlands. 5th-6th November 2019. Maternal obesity and pre-eclampsia. This was a conference organised by Biochemical Society where I gave the closing lecture as part of being awardee of the Sir Philip Randle Lecture, Biochemical Society |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://biochemistry.org/grants-and-awards/awards/the-sir-philip-randle-lecture/ |
| Description | Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Basel, Switzerland. 11th-14th September 2018. EMBO at Basel Life. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.basellife.org/basel-life-2018.html |
| Description | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Bavarian Alps, Germany. 25th-27th September 2019. AMPro Summer School for PhD Students & Postdocs. Aging and Metabolic Programming. PhD programme related to the German Centre of Cancer where I serve as SAAB |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://ampro.helmholtz-muenchen.de/news-events/past-events/ampro-summer-school-2019/index.html |
| Description | Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 7. Bilbao, Spain. 8th June 2018. Seminar at Biogune. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/CICbioGUNE |
| Description | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Boston, USA. 11th May 2018. "Adventures in Metabolism" Symposium at Harvard Medical School. Lecture related to the role of Brown fat in metabolism. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.evensi.us/adventures-metabolism-symposium-celebrate-jeffrey-flier-70th-birthday/25406324... |
| Description | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Brussels, Belgium. 18th- 21st June 2019. European Research Council -2019-STG - LS4, Step 2. This was an event where we selected the awardees of ERC starting grants |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://erc.europa.eu/document-category/evaluation-panels |
| Description | Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 10. Cadiz, Spain. 8th-11th April 2019. EMBO "Organ Crosstalk in Energy Balance and Metabolic Disease". 3 day conference organised by EMBO to discuss interorgan communication and its relevance in metabolic disease. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://meetings.embo.org/event/19-organ-crosstalk |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Cambridge Science Festival - covering all aspects of the world-leading research happening at Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.tvplab-cambridge.com/post/diana-cambridge_festival-2021 |
| Description | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Cambridge, United Kingdom. 2nd -4th July 2019 EAS Advanced Course in Cardiometabolic Phenotyping Training hands on to develop expertise in cardiometabolic phenotyping |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.eas-society.org/events/EventDetails.aspx?id=1211946 |
| Description | Centre on AI technology for Humankind NUS Business school |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The development of Artificial Intelligence (AI) promises amazing opportunities for transforming our lives and the way we work. It will help elevate our human potential in ways we cannot yet see or even imagine. But what are the challenges that lie ahead? Amid the hype and excitement, there is a risk that allowing technology alone to dictate the course of development may bring with it as yet unknown threats to our human condition. At AiTH, we believe that the development of AI technologies must be understood and examined in the context of collaboration and co-creation with humans. Our aim is to study, explore and develop deep insights into how AI technologies should be advanced with human-centred choices, promoting creativity and happiness whilst serving and enhancing human identity. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://bschool.nus.edu.sg/aith/people/international-research-affiliate/ |
| Description | China Medical University Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | China Medical University Conference - "The First International Conference on the Comprehensive Life Course Prevention and Treatment of Obesity and Related Chronic Diseases" |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://en.chinacdc.cn/news/latest/202201/t20220105_255718.html |
| Description | Doha, Qatar. 4th-6th December 2019 Anti-Doping Laboratory Qatar for the 7th Junior Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | This activity was related to a PhD annual conference ree=lated to the course for women in Qatar as part of the programme coordinated by Univeristy College of London, Bristol and Groningen. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Gothenburg, Sweden. 5th October 2018. Wallenberg Lab 30th Anniversary Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| Description | I'm a Scientist - Get Me Out of Here! |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | I'm a Scientist - Get Me Out of Here! During the lockdown, two members of the TVP Lab - Sonia & Jennie - took part in the MRC initiative 'I'm a Scientist - Stay at Home!'. This programme was established to allow school children to talk to real scientists during their virtual science lessons in the summer term, to find out more about the subjects they were interested in! Sonia was in the 'Disease Detectives Zone', while Jennie was in the 'Medical Research Zone'. They both had a lot of fun, and were amazed by how insightful the questions they received were! |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://imascientist.org.uk/ |
| Description | Lab Leadership in a Crisis |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Lab Leadership in a Crisis The Covid-19 pandemic has resulted in more people working from home, fewer people working in the laboratory, changes in the pattern of scientific interactions, physical barriers to direct communication, all in a context of anxiety and uncertainty about the present and the future. These difficulties are causing mental health problems, frustration, anger, and disengagement. However, this turbulent time has also enabled new, unexpected leaders to emerge, performing more autonomously and making insightful decisions. This period has provided them with opportunities to show their character, determination and resilience when confronted with challenges. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://alumni.bhf.org.uk/news/390927 |
| Description | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 20th-21 November 2019 Scientific meeting of the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) This meeting brings all teh community of investigators on the field of obesity in Spain. It is an excellent place to identify talent. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Madrid, Spain. 22nd November 2018. CIBEROBN Annual Symposium. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ciberobn.es/en |
| Description | Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | 9. Madrid, Spain. 31st May 2019. 6th Symposium on Biomedical Research "Advances & Perspectives in Molecular Endocrinology" This was a high level scientific event organised by CSIC in Madrid attended predominantly by experts in endocrinology |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eventos.uam.es/28633/detail/6th-symposium-on-biomedical-reserch-advances-and-perspectives-in... |
| Description | Naked scientist podcad |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Senior Research Associate of pour laboratory Sam Virtue on the Naked Scientist podcast - https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-soy-slingshots-and-cyanide & https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-atoms-avalanches-armpits |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/qa-soy-slingshots-and-cyanide. |
| Description | Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 5. Nanjing, China. 19th-25th May 2019. The Sino-UK Cardiovascular disease symposium. Meeting in Nanjing with faculty from Nanjing Medical School for collaborative research and networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Naples, Italy. 28th May 2018. Seminar at The Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" of the National Research Council (CNR). Lecture on the Adipose tissue expandability, lipotoxicity and metabolic syndrome. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Paris, France. 11th-15th April 2018. EASL International Liver Congress. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the Paris, France. 11th-15th April 2018. EASL International Liver Congress focused on the pathogenesis of fatty liver and the effect of Lipotoxicty |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://easl.eu/discover/events/detail/2018/the-international-liver-congress-2018 |
| Description | Public engagement at the Suffolk Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | On Monday February 17th 2020, a team of PhD students from the Institute of Metabolic Science went to the Suffolk Science Festival in Bury St. Edmunds to teach local children about neurons, the anatomy of the gastrointestinal system and the importance of insulin sensitivity. Among the team was TVP lab PhD student Jennie Leggat. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.tvplab-cambridge.com/post/public-engagement-at-the-suffolk-science-festival |
| Description | Science News Study inMice suggests drug to turn fat brown could help fight obesity |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | https://www.sciencedaily.com/releases/2018/11/181126123416.htm Study in mice suggests drug to turn fat 'brown' could help fight obesity Date:November 26, 2018 Source:University of Cambridge Summary:Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists have found a way of making the white fat 'browner' and increasing the efficiency of brown fat. While their study was carried out in mice, they hope that this finding will translate into humans and provide a potential new drug to help fight obesity. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sciencedaily.com/releases/2018/11/181126123416.htm |
| Description | Seminar at The Diabetes Research Center, University of Iowa |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Iowa, USA (virtual). 4th October 2021. Seminar at The Diabetes Research Center, University of Iowa |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://medicine.uiowa.edu/diabetes/event/76651 |
| Description | Seminar at the Center for Diabetes and Metabolic Diseases, Medical Faculty, Indiana University. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2. Indiana, USA (virtual). 13th December 2021. Seminar at the Center for Diabetes and Metabolic Diseases, Medical Faculty, Indiana University. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://medicine.iu.edu/research-centers/diabetes/enrichment/seminar-series |
| Description | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Valencia, Spain. 17th - 18th October 2019. Liver Investigation: Testing Marker Utility in Steatohepatitis (litmus) 3rd General Assembly. This was the annual meeting of the IMI Litmus where we are aiming to identify biomarkers of NASH. My group leads the preclinical programme and presented advances in cross species validation of biomarkers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://litmus-project.eu/ |
| Description | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://en.wikipedia.org/wiki/Antonio_Vidal-Puig |
| Description | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 November 27, 2018 Could this be a solution for the obesity crisis? Samuel Virtue, University of Cambridge; Antonio Vidal-Puig, University of Cambridge, and Vanessa Pellegrinelli, University of Cambridge Scientists manage to boost brown fat in mice with a molecule called BMP8b. Could this be the future for treating obesity? |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://theconversation.com/could-this-be-a-solution-for-the-obesity-crisis-106283 |
| Description | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Örebro/Sweden. 26th-28th August 2018. Nordic Metabolomics Conference. Role of lipidomics in metabolic research Opening keynote lecture Antonio Vidal-Puig (University of Cambridge, UK) "Adipose tissue expandability, lipotoxicity and the metabolic syndrome" |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oru.se/english/about-us/conferences/nordic-metabolomics-conference/program/ |