UK Dementias Platform
Lead Research Organisation:
Cardiff University
Department Name: School of Medicine
Abstract
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
Technical Summary
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translation pipeline from basic discovery through to early phase trials (Fig 1). By combining the analytic and statistical power of >20 clinical and population cohorts representing 2M participants and creating a large readiness cohort, UKDP will create an optimal environment for basic discovery activities relevant to the clinical progression and human impact of dementia. Although UKDP is intended as a strategic and sustainable resource generating increasing scientific benefit over time, it will also deliver short and medium term benefits through the analysis of existing data, the enrichment of strategically selected cohorts, developing new ways of working with industry, and generating interest and further funding for dementias research generally.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
Planned Impact
The platform will use several vehicles to deliver impact.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
Organisations
- Cardiff University (Collaboration, Lead Research Organisation)
- Araclon Biotech (Collaboration)
- University of Porto (Collaboration)
- University of Manchester (Collaboration)
- University College London (Collaboration)
- Catalan Health Institute (ICS) (Collaboration)
- Newcastle University (Collaboration)
- University of Liege (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- AstraZeneca (United Kingdom) (Collaboration)
- EMBL European Bioinformatics Institute (EMBL - EBI) (Collaboration)
- Janssen Research & Development (Collaboration)
- SomaLogic (Collaboration)
- Ixico (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- University of Bristol (Collaboration)
Publications
A ND
(2019)
Viscosity and fragility of confined polymer nanocomposites: a tale of two interfaces.
in Nanoscale
Agarwal D
(2020)
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
in Nature communications
Ahmad S
(2018)
Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study.
in Alzheimer's & dementia : the journal of the Alzheimer's Association
Akbari A
(2020)
Creating A Research Ready Data Asset and Empowering Dynamic and Efficient Research: The Sail Dementia E-Cohort (SDEC)
in International Journal of Population Data Science
Alex B
(2019)
Text mining brain imaging reports.
in Journal of biomedical semantics
Allan CL
(2016)
Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
in Journal of affective disorders
Allardyce J
(2018)
Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.
in JAMA psychiatry
Allen N
(2020)
Mirtazapine's effect on the QT interval in medically hospitalized patients
in Mental Health Clinician
Allen ND
(2020)
Disability Evaluation and Treatment for Patients With Psychiatric Disorders.
in Mayo Clinic proceedings
| Description | Deputy Director DPUK |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Membership of a guideline committee |
| Description | PCA criteria 2013-2015 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | http://www.alzforum.org/news/conference-coverage/researchers-join-draw-posterior-cortical-atrophy-ou... |
| Description | ABN Research Fellowship (Cope) |
| Amount | £180,000 (GBP) |
| Funding ID | RG78594 |
| Organisation | Association of British Neurologists (ABN) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2015 |
| End | 11/2018 |
| Description | Additional funding from Janssen for Synaptic Plasticity work |
| Amount | £400,000 (GBP) |
| Organisation | Johnson & Johnson |
| Department | Janssen Pharmaceuticals |
| Sector | Private |
| Country | United States |
| Start | 12/2016 |
| End | 12/2017 |
| Description | Alcohol misuse: electronic longitudinal alcohol study in communities |
| Amount | £1,200,000 (GBP) |
| Funding ID | ES/L015471/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Brains for Demention Research Programme |
| Amount | £225,571 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 03/2018 |
| Description | Computational Tools for Parkinson's disease Therapeutics |
| Amount | £20,000 (GBP) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2018 |
| End | 01/2019 |
| Description | Dementias Platform |
| Amount | £6,618,190 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2014 |
| End | 06/2019 |
| Description | Improving prevention trials in AD through imaging |
| Amount | £249,965 (GBP) |
| Funding ID | 261 (AS-PG-15-025) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2017 |
| Description | Investigation of T cell reactivity to alpha-synuclein in Parkinson's disease. |
| Amount | £620,000 (GBP) |
| Organisation | Bristol-Myers Squibb |
| Department | Celgene |
| Sector | Private |
| Country | United States |
| Start | 10/2018 |
| End | 09/2021 |
| Description | JPND |
| Amount | £350,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | MRC Deep and Frequent Phenotyping Grant (Simon Lovestone PI, awarded 2016) |
| Amount | £6,900,000 (GBP) |
| Funding ID | MR/N029941/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) - Sally Cowley |
| Amount | £90,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Description | Oxford Parkinson's Disease Centre Discovery Cohort PBMCs for T cell reactivity study |
| Amount | £78,528 (GBP) |
| Organisation | Bristol-Myers Squibb |
| Department | Celgene |
| Sector | Private |
| Country | United States |
| Start | 09/2018 |
| End | 09/2019 |
| Description | ROADS IMI2 call 6 |
| Amount | € 4,000,000 (EUR) |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Sector | Public |
| Country | Belgium |
| Start | 09/2016 |
| End | 08/2018 |
| Description | The development of digital biomarkers for dementia |
| Amount | £1,200,873 (GBP) |
| Organisation | Eli Lilly & Company Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 11/2022 |
| Description | UK Dementias Platform |
| Amount | £13,607,814 (GBP) |
| Funding ID | MR/L023784/2 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 06/2019 |
| Description | Uniting iPCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford |
| Amount | £80,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 09/2019 |
| Description | renewal funding for the Alzheimer Scotland Dementia Research Centre, An objective of the Centre was to leverage external funding which DPUK funding helped to meet. |
| Amount | £750,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 04/2020 |
| Title | CRISPR gene editing |
| Description | We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | We have been able to perform gene editing in iPSC lines. |
| Title | Cognitive test battery implemented in UK Biobank |
| Description | DPUK has developed a cognitive test battery suitable for use in large-scale population studies. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The battery has been deployed in the UK Biobank study |
| Title | DPUK data portal |
| Description | The DPUK secure data analysis platform for dementia research brings together over 30 UK cohorts (n=2M) for data sharing. This is a step-change in UK data sharing capacity |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | By bringing the researcher to the data , the DPUK data portal reduces the transaction costs of data sharing at many levels. The concept has proven attractive to researchers form France, Netherlands, China, Japan, South Korea, Canada and the US and discussions are underway with these colleague to include their data within the portal. |
| URL | http://www.dementiasplatform.uk/ |
| Title | Imaging network protocols |
| Description | The DPUK molecular and structural imaging network has been awarded a MRC partnership grant and an ARUK project grant t develop standardised image acquisition and pre-processing protocols for brain imaging. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | TO BE CONFIRMED |
| Title | Live cell imaging techniques in iPS-derived DA neurons in vitro |
| Description | We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. |
| Title | RNA-Seq |
| Description | Development of methods for analysis of RNA-Seq |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Understanding of gene expression profiles in selected cell population |
| Title | Stem cell network protocols |
| Description | The DPUK stem cell network has been awarded a MRC partnership grant to establish network activity including the development of standard protocols for developing specific tissue types relevant to dementia research. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | TO BE CONFIRMED |
| Title | Target discovery assays |
| Description | Develop target discovery assays using high throughput screens |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | New research facilty built for our work |
| Title | WP13 Agreed Standards for Collection, Classification & Storage of Brain Tissue |
| Description | This report relates to Dementias Platform UK (DPUK) Objective 3 of Work Package 13: Brain Donation. Specifically, objective 3 is to develop agreed standards for the collection, classification and storage of brains tissue. Harmonisation of procedures across brain banks enables i) comparable standards of quality and diagnostic categorisation to be employed, ii) implementation of comparable sampling, preparation and storage techniques and iii) provision of consistent key tissue quality and pathology data. Consistent with the diversity of researcher requests, it is also necessary to preserve a sufficient degree of operational flexibility in accordance with the nature of the disease and user demand. In such instances, a rationale and explanation of any differences can be provided, or where appropriate, a view presented as to when convergence might be achieved in the future. The policies outlined below are those agreed by the 4 Medical Research Council (MRC) funded brain banks as part of a milestoned funding package and are used as a minimum protocol by all the banks in the MRC UK Brain Bank Network (UK BBN). Minimal standards for collection are presented in relation to i) Brain tissue, ii) Clinical and Neuropathological information and iii) Neuropathology (Classification & storage). |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | pending DPUK consensus meeting on brain donation strategy |
| Title | WP13 Brain donation UK Brain Bank capacity and strategy for UK brain donation |
| Description | 1. This report relates to DPUK Work Package 13 Objective 7: To establish a brain banking strategy based on capacity and scientific value. 2. The report presents quantitative and descriptive data relating to the current capacity and workload of 10 UK brain banks, evaluates options for extending brain donation to DPUK cohorts and makes recommendations for a longer term brain donation strategy. 3. Currently there is little spare capacity available across the UK Brain Bank Network. 4. Across the brain banks there are significant differences in the proportion of ad hoc vs registered brains collected. 5. Estimates of the number and characteristics of participants to be consented to brain donation through DPUK are required in order to predict the impact of DPUK with greater precision. 6. The availability of mortuary services is a potential bottleneck & there is a need to engage with NHS Trusts. 7. Clarification of scientific questions and identification of what DPUK seek to learn from donated brains would help to shape a brain donation strategy. 8. Conditional support for a UK Biobank brain donation pilot study. 9. A decentralised model based upon the accommodation of extra DPUK activity within existing brain bank infrastructure across the 10 brain banks is favoured. 10. The long term suitability of alternative models for consenting, centralised collection and storage warrant exploration. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Basis for consensus meeting on new approaches to UK brain banking. To inform a pilot study using UK Biobank and the Manchester Brain Bank. Presentation of alternative models for consenting, registration, coordination of participants and collection, processing, storage and retrieval of brain samples |
| Title | WP13 Brain donation: Sample access plan. |
| Description | A briefing document on access to post-mortem samples and data from the proposed DPUK collection From the discussion above decisions concerning access to DPUK samples and data need to be taken at an early stage. A number of key factors determine the framework for granting access to tissue samples, accompanying neuropathological and clinical data through a DPUK platform. These factors relate to custodianship, ethical approval, eligibility for access, the application process and the conditions of access. Following specific DPUK guidance in relation to each of these factors, subsequent actions in defining a sample access plan include the development of 1) a standard operating procedure, 2) principles of access, 3) a common request application form, 4) an application process and 5) conditions of access. While a dual approach to access implies that established brain bank and cohorts procedures will cover many aspects of the request process, the section below highlights those elements requiring unique consideration in relation to DPUK generated applications. It will be particularly important to establish a researcher FAQs to guide applicants though the process and help requesters to determine suitability of data and eligibility to gain access. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | pending DPUK consensus meeting on brain donation strategy |
| Title | Alzhemer's Disease Polygenic Risk Profiling |
| Description | This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | This approach is used to create SNP arrays for AD prediction (for research only so far). |
| Title | DPUK BIDS Formatted Imaging Data |
| Description | Imaging data collected by DPUK have been converted to BIDS format creating a research ready data collection. The standardised formating of the datasets will allow researchers to be be able to access and analyse the data more efficiently. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | The production of the data collection has enabled Imaging preprocessing pipelines research to begin within the DPUK data portal. There are also 15 Imaging projects accessing the BIDS formatted data. |
| URL | https://portal.dementiasplatform.uk/AnalyseData/ImagingMatrix |
| Title | DPUK Genomics portal |
| Description | The DPUK Genetics portal provides a collaborative platform for individuals, DPUK cohorts and the wider research community to share and access research outputs from genetic research. The platform provides two key tools for finding, sharing and analysing genetic data; The Results Registry tool, accessible via the main DPUK web portal, allows searching and uploading of genetic results data. This tool provides a rich set of search tools specific to genetic data and includes visualisation using the popular JBrowse genomic browser. This tool will allow users to share this data. This can be done under secure data transfer agreements if necessary. The second tool is the Genetic Data Browser this is available exclusively within the secure DPUK infrastructure. This will allow users to create cross-cohort comparison studies based on genotypic datasets and linked phenotypic data. This tool provides an interactive dashboard which can pull in phenotypic data and genetic markers from GWAS data and allow users to intuitively explore, combine and export patient cohorts. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The DPUK Genetics portal, housed on the DPUK platform, allows non bioinformatic-expert users to explore components of genetic data within a secure environment. We have provided access to an international consortium, GERAD, via the DPUK data portal. This is a dataset of over 18,000 cases and controls (detailed in Table 2), as well as over 5,600 samples to date submitted to the EADB, the European AD DNA bank for deciphering the missing heritability of Alzheimer's disease |
| URL | https://portal.dementiasplatform.uk/ |
| Title | DPUK cohorts database |
| Description | collection of >30 UK cohorts available for cross-cohort analyses |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The bringing together of data from >30 cohorts is transformative in delivering greater data access to the research community |
| URL | http://www.dementiasplatform.uk/ |
| Description | Abeta functional assays |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to develop improved in vitro analysis odf Abeta function |
| Collaborator Contribution | Collaborative development of assay |
| Impact | Ongoing collaboration |
| Start Year | 2015 |
| Description | Collaboration with Oxford Drug Discovery Institute (ODDI) |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | In the collaboration with the Oxford Drug Discovery Institute (ODDI) my team's role is to undertake cell and molecular biology wet lab work to better understand the interaction between HDAC4, NCOR and HDAC3 and how inhibition of HDAC4 will alter that interaction. |
| Collaborator Contribution | The role of Oxford Drug Discovery Institute (ODDI) is to test the potency and activity of a range of HDAC4 inhibitors and to consider the drug like properties of new and existing inhibitors. In later stages of the project the ODDI may progress towards high throughput screening to identify novel chemistry and novel HDAC4 inhibitors. |
| Impact | Collaboration initiated 2 months ago and work underway. |
| Start Year | 2020 |
| Description | DPUK Analysts Expert Community |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Cambridge |
| Department | MRC Biostatistics Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK DSCN |
| Organisation | Cardiff University |
| Department | School of Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University College London |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Cambridge |
| Department | Gurdon Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Manchester |
| Department | Manchester Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK Genetics Expert Community |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing infrastructure and contacts with academics in the expertise of Genetics. |
| Collaborator Contribution | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
| Impact | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
| Start Year | 2014 |
| Description | DPUK Ontologies Expert Community |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK industry partnership |
| Organisation | Araclon Biotech |
| Country | Spain |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | Ixico |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | Janssen Research & Development |
| Country | Global |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | SomaLogic |
| Country | United States |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | Electrophysiology in iPSC neurons |
| Organisation | University of Oxford |
| Department | Department of Pharmacology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons |
| Collaborator Contribution | Helped us to establish the technique |
| Impact | Ongoing collaboration |
| Start Year | 2014 |
| Description | GR@CE |
| Organisation | Catalan Health Institute (ICS) |
| Country | Spain |
| Sector | Public |
| PI Contribution | we analyse the genome-wide data |
| Collaborator Contribution | the collaborators provided the data to us |
| Impact | it is a multidisciplinary collaboration, involve clinicians, biologists and bioinformaticians |
| Start Year | 2020 |
| Description | GWAIS |
| Organisation | University of Liege |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We bring our expertise in AI and ML |
| Collaborator Contribution | Collaborators bring their expertise in genetic interaction analyses. |
| Impact | It is a multidisciplinary collaboration involving mathematicians, software developers and bioinformaticians |
| Start Year | 2021 |
| Description | MINDMAPS |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MINDMAPS is a DPUK-enabled project - it used our support and infrastructure in order to gain partnership and funding. |
| Collaborator Contribution | The protocols for the MINDMAPS intended to evaluate three novel radioligands that are intended to quantify the regional availability of other radioligands being brought online for GMP production. 3 protocols are in place.This study has been set up as a public-private collaboration and has leveraged substantial new investment, both from the MRC and from other funders. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2017 |
| Description | MRC fellowship |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | advice and training on genomic data analysis |
| Collaborator Contribution | A researcher, Dr. Emma Anderson, who is a highly productive junior researcher |
| Impact | 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline |
| Start Year | 2016 |
| Description | Principal Supervisor to Marta Madureira |
| Organisation | University of Porto |
| Country | Portugal |
| Sector | Academic/University |
| PI Contribution | As part of the GABBA Doctoral Program, Portugal, Professor Wade-Martins is Principal Supervisor to Marta Madureira; Co-supervisor Dr Jorge Azevedo; 01/11/18-31/12/20) |
| Collaborator Contribution | Co supervisors of student |
| Impact | Research project title: Regulation of lysosomal physiology by LRRK2 |
| Start Year | 2018 |
| Description | UK Dementia Platform (DPUK) |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee. |
| Collaborator Contribution | The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias. |
| Impact | The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol. |
| Start Year | 2014 |
| Title | DPUK Imaging Matrix |
| Description | An interactive discovery tool has been created to allow researchers to explore the imaging data available via DPUK |
| Type Of Technology | Webtool/Application |
| Year Produced | 2022 |
| Impact | Since the tool has been launched there has been an increase in applications for imaging data. |
| URL | https://portal.dementiasplatform.uk/AnalyseData/ImagingMatrix |
| Title | Digital Biomarkers for Dementia |
| Description | This collaboration aims to produce smartphone and wearable focused, remote, digital biomarkers targeted at the earliest possible preclinical signs of the disease. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2017 |
| Impact | The first of the outputs from this research collaboration are currently deployed in the PREVENT and DFP trials. |
| Title | POLARIS |
| Description | We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | NA |
| URL | https://github.com/BakerEA/POLARIS |
| Title | UKSeRP (UK Secure eResearch Platform) |
| Description | UKSeRP is a secure data management and analysis platform created through MRC's capital investment in the Farr Institute. It is an integrated suite of hardware and software tools that enables uses to upload and remotely manage their data and make the data available for analysis to distributed research teams. UKSeRP instances have been created for the MRC Dementias Platform UK, UK Biobank outcome adjudication group, ALSPAC, linked Millennium Cohort Data and the Multiple Sclerosis Register. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2014 |
| Impact | UKSeRP supports the development and implementation of distributed multi-disciplinary UK Team Science in providing access to multi-modal multi-cohort data. |
| Description | 1946 70th birthday event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | The 70th Birthday Event celebrated the 70th birthday of participants in the MRC NSHD (1946 birth cohort) - we provided a display of brain imaging |
| Year(s) Of Engagement Activity | 2016 |
| Description | 21/01/2021 - Data Science and Population Health Research. University of British Columbia, Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Data Science and Population Health Research. University of British Columbia, Canada, 21/01/21. |
| Year(s) Of Engagement Activity | 2021 |
| Description | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal. |
| Year(s) Of Engagement Activity | 2015 |
| Description | A formal working group, expert panel or dialogue - DPUK Annual Conference 2018: The power of cohorts 23 April 2018 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended one-day conference on using DPUK platform. |
| Year(s) Of Engagement Activity | 2018 |
| Description | A moving target? Dementia in changing older populations (and a changing world) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given at AAIC 2016 (Alzheimer's Association International Conference) 23-28 July in Toronto, Canada. |
| Year(s) Of Engagement Activity | 2016 |
| Description | A population perspective on dementia and its relationship with ageing and dying across time |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at Brocher foundation, Geneva, 14-15 April 2016. The redefinition of Alzheimer's disease and its social and ethical consequences. |
| Year(s) Of Engagement Activity | 2016 |
| Description | ARUK 2014 Annual Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Julie Williams took part in a debate at the 2014 ARUK conference titled: Alzheimer's disease: The relative importance of Genes and Environment The conference audience took part in the debate and positive feedback was recieved about this part of the conference. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.alzheimersresearchuk.org/conference-programme/ |
| Description | ARUK Manchester Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The Alzheimer's Research UK Conference is the UK's largest dementia research conference and this year Alzheimer's Research UK hope to host up to 450 delegates in the Neo-Gothic surroundings of Manchester Town Hall. With no parallel sessions, this is the perfect conference to gain insight from basic researchers through to clinical colleagues. Latest insights from basic and clinical research. |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.dementiasplatform.uk/event/alzheimers-research-uk-conference-2016/ |
| Description | ARUK Network Open Morning |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | ARUK Oxford Drug Discovery Institute |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presenter at the ARUK Oxford Drug Discovery Institute (ODDI) Collaborators meeting |
| Year(s) Of Engagement Activity | 2020 |
| Description | ARUK Oxford Network Research Day presentation July 2019 - Bryan Ng |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | In July 2019, Bryan Ng attended the ARUK Oxford Network Research Day and gave a presentation |
| Year(s) Of Engagement Activity | 2019 |
| Description | ARUK Public Engagement open day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public engagement |
| Year(s) Of Engagement Activity | 2015 |
| Description | ARUK Scientific meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Scientific meeting |
| Year(s) Of Engagement Activity | 2015 |
| Description | ARUK conference 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Lots of questions More interest in taking part in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | ARUK conference poster presentation in March 2020 - Bryan Ng - EVENT CANCELLED DUE TO CORONAVIRUS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | ARUK conference poster presentation in March 2020 - Bryan Ng |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.alzheimersresearchuk.org/for-researchers/research-conference-2020/abstracts/ |
| Description | ARUK scientific meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Awareness raising for DPUK and building networks. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's & Parkinson's Disease Congress 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PD 2015) will build on the well-earned reputation of previous AD/PD meetings for unraveling the mechanisms and improving the treatment of Alzheimer's, Parkinson's and other related neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=3 |
| Description | Alzheimer's Association International Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International Conference to highlight progress made and new opportunities in dementia research. AAIC attracts international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's Association International Conference (AAIC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's Society Annual Research Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The Dementias Platform UK: what is it and what can it do for you? The Alzheimer's Society Annual Research conference will take place on 29-30 June 2015 at the Mercure Manchester Piccadilly Hotel. The conference will bring together researchers and people affected by dementia. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
| Description | An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An interview for Video Journal of Dementia |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.vjdementia.com |
| Description | An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Horizon - filming 2015-16 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Horizon were interested in making a programme about Alzheimer's disease with a focus on novel technology - especially imaging - for early diagnosis and trials. Several meetings were held with the produced and his team and then several days of on-site filming including following a research subject. The film is due to be shown in Spring 2016 as a one hour long programme which is likely to reach an audience of more than a million |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | BBC Panorama |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Julie Williams Research Team were approached to be involved in a BBC documentary. The documentary followed one of our research participants and his family through everyday life with Alzheimer's disease. Field workers and laboratory staff were also filmed in their roles. The documentary was screened on BBC1 in Panorama on 2nd June 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC Wales Dementia Week 2016 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Filming with BBC Wales's Owain Clarke on Thursday (12th May, 10-12). Interview is part of a package he's doing for Alzheimer's Awareness Week. Owain will be asking Prof Williams about Wales's research contribution; her own specific research and; look ahead at what's next. Various excerpts were screened on BBC news throughout the week, featuring a number of different staff from the team at Cardiff. This raised awareness of our work and the profile of the team. |
| Year(s) Of Engagement Activity | 2016 |
| Description | BBC panorama |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | BBC Panorama are following an EOAD participant. The initial interview was filmed by the BBC |
| Year(s) Of Engagement Activity | 2016 |
| Description | British Neuropsychiatric Association Annual meeting 24 February - medalist lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion of nosological challenges in dementia. |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf |
| Description | British Science Festival 2016 Workshops |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We used VR tools to demonstrate the impact of dementia on people's everyday lives. These included using the experiences "A Walk Through Dementia", our citizen science game "Sea Hero Quest", some activities from out children's website, as well as hands on activities and memory games. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.britishsciencefestival.org/ |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk led to a lot of questions and discussion - for almost an hour after the event A number of people expressed interest in taking part in research |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | http://www.dementiasplatform.uk/event/cheltenham-science-festival/ |
| Description | Cheltenham Science Festival (in partnership with Alzheimer's Re-search UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Sponsored event - How your life affects your brain. Can the way you live reduce your chance of developing Alzheimer's? By monitoring groups of people over their lifetimes, and with genetic data, brain scans and medi-cal histories researchers are building as complete a pic-ture as possible of how dementia develops. John Gallacher and Nick Fox join us to show how these stud-ies can uncover the risks involved in developing forms of dementia, and how they can be avoided. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
| Description | Co-organised Synaptic Health Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A 2 day workshop for the Synaptic Health experimental medicine work package. Attendees were academics and industry scientists involved in the workpackage or who are interested in collaborating. Outcomes were decision to write a number of collaborative research proposals to obtain research funding. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl... |
| Description | Competent Authorities for Medical Devices Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion to influence policy and practice relating to medical devices. |
| Year(s) Of Engagement Activity | 2016 |
| Description | DPUK Annual Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | DPUK's annual scientific conference 2017 is open to researchers, funders, government, charities and the public. The keynote speaker will be Monique Breteler. The focus of the day will be on demonstrating tools, presenting data on outcomes to date, and showcasing the complementarity of the Dementia Resource Institute and Dementias Platform UK. This will be the fourth DPUK conference. |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
| URL | http://www.dementiasplatform.uk/event/dementias-platform-uk-annual-conference-2016/ |
| Description | DPUK Cohort Engagement Seminar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The purpose of the Cohort Seminar is to provide an overview of the Dementias Platform UK, build relationships with cohorts and formally invite cohorts to be part of DPUK. |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.dementiasplatform.uk/events/?yy=2016&mm=1 |
| Description | DPUK Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The DPUK newsletter is issued three times a year. It regularly includes updates from the Director, notifications of the conference and other events, news on project successes, and information on collaborative activity and any awards available. Through the newsletter, there is increased engagement from the project's target audiences with DPUK's work and events. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019 |
| Description | DPUK Stakeholders Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Raised awareness of use of stem cells in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London - 3/11/14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London |
| Year(s) Of Engagement Activity | 2014 |
| Description | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff - 27/11/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff |
| Year(s) Of Engagement Activity | 2016 |
| Description | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton - 11/10/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dementia and a Research Institute - Interview in the Sun Newspaper 5Oct15 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Publicity to promote the fact that 5p from each carrier bag bought would be donated to the Dementia Research Centre. This was the brainchild of Malcolm Walker (Iceland) with Nick Fox (DRC) |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.thesun.co.uk/sol/homepage/woman/health/health/6735025/5p-bags-could-help-combat-dementia.... |
| Description | Dementia: population and public health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given for the visit of the DRI director on 19 October 2016 at the University of Cambridge, IPH. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dementias Platform UK (DPUK) Scientific Symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The purpose of the Symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically looking at the main themes of Cohorts, Networks and Experimental Medicine. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board - 15/12/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London - 24/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition; an outreach event to schools in Oxfordshire. The University of Oxford invited schools to participate in an art competition for Oxfordshire state school students to create art inspired by research from Black, Asian and Minority Ethnic scientists. Students were asked to choose one of six scientists to create an artistic response to their research (e.g. painting, drawing, sculpture, animation, other artistic media) along with a short statement explaining the artwork. Due to COVID-19, there was a delay to announcing the winners. The winners are to be called in January 2021 and an exhibition of their work will take place online now. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxfordsparks.ox.ac.uk/content/beyond-boundaries-2020 |
| Description | EPAD consortium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attendance at event to collaborate with partners to share progress in dementia research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Eisai Ltd webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited presenter at Eisai Ltd webinar |
| Year(s) Of Engagement Activity | 2020 |
| Description | Ethical Risk Assessment in Biomedical Big Data - Protecting privacy through design |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Protecting privacy through design |
| Year(s) Of Engagement Activity | 2016 |
| Description | European Medical Information Framework |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 75 EMIF team members gathered in Budapest March 14-16, 2016 to not only share status updates on the ongoing work, but also discuss new joint AD/Metabolic scientific questions to be addressed using the EMIF framework. Overall, tremendous progress was shown for both research projects, with many more exciting results being underway and opportunities for further collaboration identified. In particular the overlap between AD and metabolic disorders, due to inflammation, such as in Diabetes Mellitus Type 2, has provided opportunities for shared work. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.emif.eu/news?news_news=5 |
| Description | European Medical Information Framework conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research conference to demonstrate use of new tools and methods for the dementias research community. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.emif.eu/ |
| Description | External talk at the ITMAT workshop on data science challenges and opportunities in Translational Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk to influence research on data science challenges. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference - 24/8/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference, Swansea |
| Year(s) Of Engagement Activity | 2016 |
| Description | Fundraising activity during lockdown for Parkinson's UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | During the Covid pandemic lockdown, members of the Wade-Martins Group from the Oxford Parkinson's Disease Centre fundraised for Parkinson's UK with a variety of imaginative challenges for the national 2.6 challenge campaign. £1,197 was raised for the charity. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.dpag.ox.ac.uk/news/opdc-researchers-hit-target-for-parkinsons-uk-with-2-6-challenge |
| Description | Generation Scotland Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Awareness raising for DPUK and building networks. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Health and Care Research Wales Public Engagement talk 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Institute of Psychological Medicine and Clinical Neurosciences staff at Cardiff University School of Medicine were required to attend a one hour presentation on the importance of engaging with the public in scientific research. The aim was to give staff a greater appreciation of public involvement, and the benefits of this in research. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.healthandcareresearch.gov.wales/involving-the-public-in-your-research |
| Description | Hong Kong University - international lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | These numerous lectures provided DPUK in depth overview and dementia related discussions. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Inaugural academic conference: Tools for science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Inaugural conference for Dementias Platform UK to engage researchers in our academic and industry partner institutions and beyond. Presentations from speakers covering all areas of the Dementia Platform and cohorts encouraged to join the platform. Engagement of early career researchers through a poster presentation competition. 37 posters were exhibited, some with interactive stands, and demonstrated the progress of work delivered through the DPUK Work Programme and Infrastructure Networks. Dr Carol Routledge discussed the opportunities available through the Dementia Discover Fund and Maria Carrillo, PhD, Chief Science Officer from Chicago gave her first impression of DPUK "The Dementias Platform UK and Alzheimer's Association have a lot of opportunity to collaborate in the future in my view and John Gallacher and his team have also agreed with that, and this is one of the reasons why we have been asked to listen in and help future thinking and brainstorm ideas that might come about with DPUK's established network." |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/tools-for-science-dpuks-first-annual-conference-in-brief/ |
| Description | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London - 19/10/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London - 23/11/15 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London Decision made that a Neurodevelopmental Disorders Research Network would require a data platform similar to the Dementias Research Platform UK |
| Year(s) Of Engagement Activity | 2015 |
| Description | Insight 46 launch facebook offices |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talk sparked questions and included George Freeman MP - Minister for Life Sciences A number of members of the audience asked for further information |
| Year(s) Of Engagement Activity | 2015 |
| Description | International Alzheimer's Disease Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation in international conference. This was an opportunity to share progress and updates in dementia research infrastructure with Alzheimer's Disease Research Network, SRT Ageing, & Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong Co-organized this with the Faculty of Architecture, Faculty of Social Sciences, Sau Po Centre on Ageing & SRT Science of Learning, The University of Hong Kong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Shenzhen University (College of Life Sciences), Hong Kong Science & Technology Parks Corporation, & The Hong Kong Society of Aging Research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited member of Polygenic Risk Scoring Expert Panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited member of Polygenic Risk Scoring Expert Panel for Illumina company, Batimore, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited seminar at Icahn School of Medicine at Mount Sinai |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at Icahn School of Medicine at Mount Sinai, NY, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker at Alzheimer's Research UK conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Alzheimer's Research UK conference, Harrogate UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited speaker to FBRI Alzheimer's Disease Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker to FBRI Alzheimer's Disease Workshop, Boston, USA |
| Year(s) Of Engagement Activity | 2019 |
| Description | Janssen Symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and collaboration with industry partners. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference, St Petersburg 2019. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote speaker at The University of Reading SIAM-IMA student chapter conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Keynote speaker at The University of Reading SIAM-IMA student chapter conference, Reading, UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Late night event at The Science Museum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Launch of the MRC UK Dementias Platform, Royal Society, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 200 people attended the conference launch. I presented as leader of the Informatics Platform Work Package in the morning and the interactive discussion with industry in the afternoon a number of contacts were made with industry colleagues with plans for follow up meetings |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.mrc.ac.uk/research/facilities/dementias-research-platform-uk/ |
| Description | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London - 6/7/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London |
| Year(s) Of Engagement Activity | 2016 |
| Description | MRC CNGG/NCMH/CADR stand at the Wales Gene park's Genetics and Genomics Conference |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Representatives from the Alzheimer's Genetics Team manned a stand at the Wales Gene Park's Genetics and Genomics Conference on 22nd June, 2016. A number of individuals were interested in discussing the research environment, and how participants could help with discovery science. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.eventbrite.co.uk/e/genetics-and-genomics-for-the-3rd-generation-tickets-24871582573 |
| Description | Medicine and Me: Living well with Dementia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Giving a talk on types and diagnosis of dementia at this half day meeting. The Medicine and Me series of meetings at the RSM aim to update on important conditions and gives a direct voice to patients and their carers to air their concerns on the impact of diagnosis, investigation and management. Physicians and surgeons and indeed all healthcare professionals continue to learn from and be inspired to greater efforts by our patients to improve care. The audience at this meeting will comprise of those living with dementia, their families, carers and advocates, representing about 70% of those present; and clinicians and researchers, representing not more than 30%. Clinicians will include doctors, specialist nurses and others involved in the treatment and care of those who have this condition |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.rsm.ac.uk/events/events-listing/2015-2016/groups/public-engagement-programme/mmg01-medic... |
| Description | Meetings with Insight46 donors via ARUK |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Meeting with Insight46 donors via ARUK to discuss Insight46 and dementia research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Melodem progress meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation in a progress meeting for dementia researchers. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Agenda_Melodem_30June-and-1-july-2016_v1.... |
| Description | Mental Health Data Science Meeting (event part-funded by Farr Institute CIPHER) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Assessment of complex interventions using routine data |
| Year(s) Of Engagement Activity | 2016 |
| Description | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods - 6/7/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods, Bath |
| Year(s) Of Engagement Activity | 2016 |
| Description | New Alzheimer's risk genes discovered in record study |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A press release was issued highlighting the discovery of 11 new susceptibility genes for AD by the IGAP consortium. Details of these findings were published by all of the main UK news organisations. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.cardiff.ac.uk/news/articles/new-alzheimers-risk-genes-discovered-in-record-study-11975.ht... |
| Description | OPDC Seminar 20 January 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Matthew LaVoie gave a talk on 'Proteostasis and Mitochondrial Pathways in the Pathogenesis and Treatment of Parkinson's Disease on Monday 20 January 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar 3 February 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Michael Ward, National Institute of Neurological Disorders and Stroke, gave a talk on 'Combining iPSCs and 'omics to identify molecular convergence in neurodegenerative disorders' on Monday 3 February 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar 9 March 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of of Professor Richard Wade-Martins, Dr Hélène Plun-Favreau, UCL Institute of Neurology gave a talk on Mitophagy: from genetics to biology, and back on 9 March |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar April 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 20 April, Professor Daniel Otzen. Interdisciplinary Nanoscience Center (iNANO), Aarhus University will give a talk on the 'Targeting cytotoxic alpha-synuclein oligomers in Parkinson's Disease'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/professor-daniel-otzen-20-04-20 |
| Description | Online OPDC Seminar 10 December |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 10 December, Richard Youle, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA, gave an online talk 'Mechanisms of Innate Immunity and Parkinson's Disease'. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Online OPDC Seminar 13 October |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 13 October, D. James Surmeier, Feinberg School of Medicine at Northwestern University, USA, gave an online talk on the 'Time to revise the classical model of basal ganglia dysfunction in PD: New insights from a novel, progressive mouse of mitochondrial complex I dysfunction'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 15 June |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 15 June, Tim Bartels, UK Dementia Research Institute (DRI), University College London (UCL) gave an online talk on the 'Selective brain region vulnerability in Parkinson's Disease is governed by a-Synuclein conformations'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 18 May |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 18 May, Vincenzo Bonifati, Erasmus University Medical Center, Rotterdam, gave an online talk with 'An update on the quest for genetic determinants in Parkinson's Disease'. & related diseases |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 20 April |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 20 April, Daniel Otzen, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, gave an online talk on the 'Targeting cytotoxic alpha-synuclein oligomers in Parkinson's Disease' |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 22 September |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 September, Jacqueline Burré, Brain and Mind Research Institute at Weill Cornell Medicine, USA gave an online talk on 'Function and Dysfunction of Synucleins - Membranes Matter'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 6 July |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 6 July, Madeline Lancaster, MRC, Laboratory of Molecular Biology, Cambridge, gave an online talk on 'Exploring human brain structure and function using cerebral organoids'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 9 November |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 9 November, Valina Dawson, John Hopkins University School of Medicine, Baltimore, Maryland, USA gave an online talk 'Decoding Parkinson's Disease: New Therapeutic Opportunities'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Oxford Dementia Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The event showcased the latest developments in memory, dementia and ageing research from cells and animal models to cognitive neuroscience and the clinic. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015 |
| Description | Parkinson's Oxford Walk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Members of OPDC took part in Parkinson's UK Oxford Walk. OPDC also hosted an information stand at the event. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.parkinsons.org.uk/events/walk-parkinsons-oxford |
| Description | Plenary Speaker at Clinical Trials in Alzheimer's Disease (CTAD) conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Plenary Speaker at European Academy of Neurology on Imaging Trials and Dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Population data and modelling: dementia as exemplar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given at the Cumberland Initiative Festival of Evidence on 5 October 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation at High Performance Computing and Big Data Conference, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation title - Improving health through Big Data - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation at International Health Data Linkage Conference, Vancouver |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title - Using data linkage to support measurement of the Global Burden of Injuries - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation at MRC Strategic meeting between health and bioinformatics centres - 29/1/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Centre for Improvement of Population Health through E-records Research (CIPHER). Presentation at MRC Strategic meeting between health and bioinformatics centres, Windsor |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation at MRC organised conference: Strengthening the UK's capability in health informatics research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation as MRC organised conference: Strengthening the UK's capability in health informatics research. Conference was attended by 200+ delegates including, UK Minister, policymakers, research community and industry Agreement to create the Farr Institute; development of the UK Health Informatics Research Network |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentation on Health / Bioinformatics at Swansea University. Visit of Prof Julie Williams, Chief Scientific Advisor for Wales |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation on UK Secure eResearch Platform (DPUK) - 24/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on UK Secure eResearch Platform (DPUK) at MRC meeting 'Managing the data life-cycle for stratified medicine', London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation on future Farr UK Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on future Farr UK Institute to MRC Population Health Sciences Group, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation on research at Farr Institute CIPHER to Rebecca Endean - 26/1/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation on research at Farr Institute CIPHER to Rebecca Endean, Director Research Base, Business and Science |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation to Clinithink, Swansea - 10/4/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | NLP of Emergency Department data: Early experience. Presentation to Clinithink, Swansea |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation to Precision Medicine Catapult - 17/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation to Precision Medicine Catapult tem leaders from Cambridge University at visit to Swansea University Precision Medicine Catapult team asked to come back to discuss opportunities and projects in more detail |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation to UK Biobank and Oxford Big Data Institute, Swansea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title - Use of UK Secure e-Research Platform (UKSeRP) - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation to joint meeting of UKDP, EMIF (European Medical Information Framework) and eTRIKS (European Translational Information and Knowledge Management Services), London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation title - UK Dementia Platform Informatics - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation to the MEPs about DPUK, EPAD and ROADMAP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation to MEPs about DPUK, EPAD and ROADMAP. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation to the general public on the DRI program at the DRI launch in Cardiff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I have presented on my DRI program "Bioinformatics and Functional genomics" to patients, their families, journalists and other invited guests from the general public at the DRI launch in Cardiff, October 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation with Mick Dennis (Swansea) and Daniel Davies (UCL) to UK Biobank/DPUK neorodegerative outcomes group - 6/1/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research Proposal: Dementia and Cognitive Impairment identification in routine health data: development and validation of algorithms within SAIL using CFAS cases. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua - 2/12/14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua |
| Year(s) Of Engagement Activity | 2014 |
| Description | Radio Interviews on Parkinson's |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Radio interview to raise awareness and Parkinson's fund raising sponsored event Raised awareness and money |
| Year(s) Of Engagement Activity | 2015 |
| Description | Rare Dementia Support Group Launch 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Rare Dementia Support Fund created with the ambition to increase fundraising and extend the support service further, throughout the UK and beyond. Extremely well attended |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.nationalbrainappeal.org/rare-dementia-support-launch-event/ |
| Description | School of Medicine 'Science in Health' Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Professor John Gallagher spoke at a Cardiff University public medical lecture and the aim of these lectures is to open up areas of concern in health care, and second, to inform the public about current medical research. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/event/school-of-medicine-science-in-health-public-lecture/ |
| Description | SciScreen Dementia Event |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Rebecca Sims gave a public presentation on Dementia research before a free screening of the film "Away from Her", post-film discussion and free drinks reception. The purpose of the event is for scientists to engage with the general public for mutual benefit. The presentation was well received, and the discussions were lively. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority - 7/9/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority, London |
| Year(s) Of Engagement Activity | 2016 |
| Description | Social Media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The social media presence of Dementias Platform UK is intended to demonstrate the core personality of the project, sharing: - Expert voice - A network of research excellence - Human connection. DPUK's social media presence is focused on Twitter, though in the future it may also reach LinkedIn. Social media is used to share updates on the project's work: its research, daily activity, funding awards open, news, and any open recruitments, It also demonstrates its networked and human approach by sharing content from charities, linked researchers and any current human interest news stories. Finally, in the coming months it will strengthen its ability to share its expert voice by facilitating twitter takeovers from key researchers, particularly Early Career Researchers. DPUK has 1,636 followers - a 173% increase on 2016. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| URL | https://twitter.com/dementiasuk |
| Description | Speaker at launch of UK Dementia Platform |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Oxford plays a significant role in the partnership and Oxford Neuroscience researchers lead a number of projects. This was reflected in the scientific programme of launch day. Simon Lovestone (Psychiatry) gave a talk on the NIHR-MRC Dementia Deep and Frequent Phenotyping Feasibility Study while Richard Wade-Martins (DPAG) spoke on the UK Stem Cell Network. Coverage in the media |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.dementiasplatform.uk/ |
| Description | Talk at East Midlands Research Support Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Natalie Connor-Robson - invited talk outreach, East Midlands Research Support Network, Sept 2018 Understanding Parkinson's disease - what can we learn from skin cells and mice? The East Midlands Parkinson's Research Forum is a free annual conference organised by the local Parkinson's community and supported by Parkinson's UK. The event will feature talks from top Parkinson's researchers and healthcare practitioners, Parkinson's UK staff, volunteer speakers, as well as interactive exercise sessions and a performance from The Parkinson's Choir. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.parkinsons.org.uk/events/east-midlands-parkinsons-research-forum |
| Description | Talk at the University College London, IoN Movement Disorders Centre Inaugural Symposium: |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 11 March, Professor Richard Wade-Martins gave a talk at the University College London, IoN Movement Disorders Centre Inaugural Symposium: Launch of the UCL Movement Disorders Centre |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.ucl.ac.uk/ion/events/2020/mar/ucl-ion-movement-disorders-centre-inaugural-symposium-launc... |
| Description | The Many Faces of Dementia - massive open online course (MOOC) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed for an online course about the rarer forms of dementia, my interview related to the clinical features of frontotemporal dementia. I also performed the voice over and welcome to the course that appeared in the course trailer video. The course, due to start March 14th 2016 is a 'massive open online course' available at www.futurelearn.com/courses/faces-of-dementia. Over 12,000 people have registered for the course (as of 8th March 2016). |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.futurelearn.com/courses/faces-of-dementia |
| Description | Times Radio interviews following publication of the Times article "Brain tweezers could treat Parkinson's" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In September, Professor Richard Wade-Martins & Dr Nora Bengoa-Vergniory held a Times Radio discussion on novel therapeutic approaches to Parkinson's following the publication of the Times article "Brain tweezers could treat Parkinson's" https://www.thetimes.co.uk/article/brain-tweezers-could-treat-parkinsons-sw2sjdnq9#:~:text=Minuscule%20brain%20%E2%80%9Ctweezers%E2%80%9D%20could%20treat,clumps%2C%20by%20pulling%20them%20apart |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.thetimes.co.uk/article/brain-tweezers-could-treat-parkinsons-sw2sjdnq9#:~:text=Minuscule... |
| Description | Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea - 26/10/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea |
| Year(s) Of Engagement Activity | 2015 |
| Description | UK Medical Research Council open meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion forum with partners in the dementia research field. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Welsh presentation (Cardiff Science Society) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A presentation was given in Welsh, by Alzheimer's Field Worker, Alun Meggy to the Cardiff Science Society on 21st November 2016. This was followed by questions and a discussion. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cymdeithaswyddonolcaerdydd.org |
| Description | Westminster forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Advice for policymakers on dementia research. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.westminsterforumprojects.co.uk/conference-diary |
| Description | World Innovation Summit for Health (WISH) forum (February 2015) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated as a panel member looking at issues of dementia funding and research, and how to better inform the public. A report was subsequently published based on the Summit meeting. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.nhsq.info/app/media/4053 |
| Description | Young Onset Dementia: Different impact, positive solutions conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This public meeting was held on 27th September, 2016. This was a recruitment opportunity. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.youngdementiauk.org/sites/default/files/Young%20Dementia%202016%20programme.pdf |
| Description | Young Onset and Rare Dementias 2014 event at House of Lords |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Awareness-raising event regarding young onset and rare dementias The event was attending by member of parliament and the House of Lords as well as charities, patient families and other organisations |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://www.youngdementiauk.org/news/young-onset-awareness-event-house-lords |
| Description | the UK Pharmacogenetics and Stratified Medicine Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presenter at the UK Pharmacogenetics and Stratified Medicine Network Workshop |
| Year(s) Of Engagement Activity | 2021 |