Risk and Modifying factors in Fronto Temporal Dementia
Lead Research Organisation:
University College London
Department Name: Institute of Neurology
Abstract
Fronto Temporal Dementia (FTD) is a devastating pre-senile dementia characterized by the progressive
deterioration of the frontal lobe and changes in social and personal behaviour and blunting of emotions.
Up to 40% of cases have a positive family history and this has been the key to the remarkable progress
in our understanding of the molecular basis of FTD. Seven genes have been identified of which MAPT, GRN and C9Orf72 explain >50% of familial cases, but how these different genes lead to a very similar clinical phenotype is unknown. There is no cure for FTD and success of therapy will depend on whether a single therapy can be applied to all patients or if specific approaches are needed for the distinct genetic, clinical and pathological subgroups. Therefore it is essential to identify all major genetic and environmental risk and modifying factors in the pathogenesis of the disease.
We will use existing genetic and pathological knowledge as a starting point to decode affected
processes and pathways in different groups of patients with FTD using a multi level approach based on genetic and "omics" data from patients and corresponding animal and cellular models. The biological significance of identified networks will be validated in our cellular and animal models and will pinpoint potential pathomechanisms that are specific to a single FTD-subtype or common to all forms. The results will be utilized to improve the quality of our predictions towards targeted intervention.
deterioration of the frontal lobe and changes in social and personal behaviour and blunting of emotions.
Up to 40% of cases have a positive family history and this has been the key to the remarkable progress
in our understanding of the molecular basis of FTD. Seven genes have been identified of which MAPT, GRN and C9Orf72 explain >50% of familial cases, but how these different genes lead to a very similar clinical phenotype is unknown. There is no cure for FTD and success of therapy will depend on whether a single therapy can be applied to all patients or if specific approaches are needed for the distinct genetic, clinical and pathological subgroups. Therefore it is essential to identify all major genetic and environmental risk and modifying factors in the pathogenesis of the disease.
We will use existing genetic and pathological knowledge as a starting point to decode affected
processes and pathways in different groups of patients with FTD using a multi level approach based on genetic and "omics" data from patients and corresponding animal and cellular models. The biological significance of identified networks will be validated in our cellular and animal models and will pinpoint potential pathomechanisms that are specific to a single FTD-subtype or common to all forms. The results will be utilized to improve the quality of our predictions towards targeted intervention.
Organisations
Publications
Adams HH
(2016)
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
in Nature neuroscience
Alic I
(2021)
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
in Molecular psychiatry
Altmann A
(2020)
A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE.
in Brain communications
Arber C
(2020)
Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
in Molecular psychiatry
Bandres-Ciga S
(2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.
in Movement disorders : official journal of the Movement Disorder Society
Bandres-Ciga S
(2019)
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.
in Annals of neurology
Bandres-Ciga S
(2019)
The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight
in Movement Disorders
Barber IS
(2017)
Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.
in Neurobiology of aging
| Title | METHOD FOR DIAGNOSING A NEURODEGENERATIVE DISEASE. |
| Description | The invention relates to prognostic and diagnostic tests for neurodegenerative disease, treatment regimens for neurodegenerative disease, animal models for neurodegenerative disease and screening methods for identifying drugs useful for treating such diseases. |
| IP Reference | EP2751284 |
| Protection | Patent granted |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | Not applicable yet |
| Title | c9orf72 patent filed |
| Description | c9orf72 mutation causes motor neuron disease and frontotemporal dementia. |
| IP Reference | |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | This patent will be used in diagnosis of disease. |
| Description | "Do Genetic Findings Converge on Discrete Pathophysiological Pathways?" invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 12th National Alzheimer Disease Conference, Virtual Eskisehir Turkey |
| Year(s) Of Engagement Activity | 2022 |
| Description | "Genomics in Neurodegenerative disease -- what are we up to" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture as HKUST IAS fellow, Hong Kong |
| Year(s) Of Engagement Activity | 2019 |
| Description | "Neurogenetic Foundations of Movement Disorders - The Key to Cure?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Keynote Lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | "The Genetics of the Dementias" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching lecture at Queen Square on MSc Human Genetics course 2018-19 |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2016 UCL School of Pharmacy Lecture at the Royal Society, Pathways to Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was an annual lecture and focused on the hunt for novel mechanistic drug targets for the dementias, discussing the fact that in the coming year we will be in a better position to understand whether we are on the right track in terms of drug discovery. |
| Year(s) Of Engagement Activity | 2016 |
| Description | AD research and future interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Virtual Interview Yasemin Saplakoglu Biology Staff Writer Quanta Magazine C: (347) 585-9167 New York, New York |
| Year(s) Of Engagement Activity | 2022 |
| Description | Advances in Alzheimer's Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker - The 10th Xiangya International Symposium of the Clinical and Basic Research on Neurodegenerative Disorders, China |
| Year(s) Of Engagement Activity | 2019 |
| Description | Alzheimer's disease pathogenesis: what do we know and why have clinical trials failed |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited public lecture |
| Year(s) Of Engagement Activity | 2019 |
| Description | Amyloid hypoithesis.. what was right and what was wrong Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 6th Rijeka Forum on Neurodegenerative Disease Croatian Academy of Sciences and Arts Department of Biomedical Sciences in Rijeka |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://neurolab.uniri.hr/?page_id=24#:~:text=The%206th%20Rijeka%20Forum%20of,of%20the%20amyloid%20c... |
| Description | Aß hypothesis, AD genetics" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited lecture - Wenner-Gren Center (Sveavägen 166), Stockholm, Sweden symposium : "Amyloid diseases: from biochemistry to clinical applications" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Crispr Talk - John and Selina |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture Royal London Hospital |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dementias - Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | "Preserving the Brain" is a forum on neurodegenerative diseases presented in September and October 2022, as the fourth phase of "Human Brains," Fondazione Prada's neuroscience project. Realized in collaboration with thirteen of the most prestigious international neuroscience institutes and universities, "Human Brains: Preserving the Brain - Forum on Neurodegenerative Diseases" comprises an exhibition (16 September - 10 October 2022) and a conference (6 and 7 October 2022) at Fondazione Prada's Milan premises and online. "Preserving the Brain" aims to stimulate an open and critical exchange between international scientists and experts on neurodegenerative diseases, such as Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis and Multiple sclerosis, which are widely spread and as yet incurable. The forum participants include researchers, patient associations, and representatives of health care institutions and the pharmaceutical and biotechnology industries. They will debate the current state of knowledge of these diseases and the tools currently used to fight them, while also seeking to identify lacunae in the search for possible therapies, and jointly defining priorities and strategies to sustain scientific research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%... |
| Description | Dementias - Invited Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%20in%20collaboration%20with%20thirteen,2022)%20at%20Fondazione%20Prada's%20Milan invited Lecture |
| Year(s) Of Engagement Activity | 2022 |
| Description | Epidemiology of Alzheimer's Disease and Related Disorders |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Keynote speaker on teaching course at Bordeaux School of Neuroscience |
| Year(s) Of Engagement Activity | 2019 |
| Description | Faculty of Medicine, University of Iceland Vatnsmyrarvegur 16 101 Reykjavik - Iceland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Distinguished speakers series |
| Year(s) Of Engagement Activity | 2017 |
| Description | Failures in Damage Response Underlie Late Onset Neurodegenerative Diseases and Explain the Relationship Between Pathology and Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Virtual UK-Russia online forum on Neurodegenerative Diseases and Brain Plasticity Requested by Alena Gureva | Science and Innovation Officer, UK Science & Innovation Network in Russia British Embassy Moscow | Smolenskaya Naberezhnaya, 10 | Moscow 121099 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genetic Analysis of Neurodegeneration Implicates a Failure of Damage Response Pathways Pre-recorded and live Q&A |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Neural Pathways Underlying Brain Function and Pathologies Organized by: Nature Portfolio, Chinese Institute for Brain Research, Beijing (CIBR) Supported by: Beijing Municipal Science & Technology Commission, Administrative Committee of Zhongguancun This event aims to bring together Chinese and international researchers at the forefront of brain science to share their recent achievements in helping to push our understanding forward under both normal and pathological conditions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://neuralpathways.natureresearch.cn/ |
| Description | Genetic analysis of late onset degenerative diseases implicates failures of damage response |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Speaker invitation and Announcement of The Brain Prize Awardee 2019 Copenhagen, Denmark |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Invited Lecture Weston's meeting - 50th Year Anniversary Symposium, 33 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture - Wolfson Institute for Biomedical Research (WIBR) mini-symposium - Sainsbury Wellcome Centre London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Wolfson final symposium - Institute of Child Health London |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics and neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited to present a teaching lecture to the Basal Ganglia Club Gilliatt Lecture Theatre Queen Square by Dr Amit Batla MBBS, MA (Clin Ed), MD (Med), DM (Neurology), FRCP Clinical Associate Professor (teaching), Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genetics in neurodegenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture at 2019 International Conference of Korean Dementia Association, (IC-KDA 2019) Seoul |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching to PhD students on Biomarkers for neurodegenerative diseases PhD course |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics in neurodegenerative diseases - teaching lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | "Biomarkers for neurodegenerative diseases" Day 1 - London edition PhD course "Biomarkers for neurodegenerative diseases" - 2022 |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.ucl.ac.uk/ion/study/biomarkers-neurodegenerative-diseases |
| Description | Genetics of Alzheimer's |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited lecture at Hong Kong University of Science and Technology ShenZhen branch |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Alzheimer's and other neuro-degenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - China National Genebank - Jinsha Road, Dapeng New District, Shenzhen |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Dementias |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture XXIV World Congress of Neurology, Dubai - AE |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genetics of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture at Lisbon AD/PD meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomic Analysis of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Zoom Teaching lecture - invited by Dr Kerri Kinghorn ucl lectures Neurological diseases module GENE003 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genomic analysis of neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited lecture Scientific Talk (to senior scientists) Odense University Hospital, Denmark |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomic analysis of the mechanisms of neurodegenerative disease in Denmark to PhD students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching Lecture to PhD students in neuroscience at the NeuroGrad Winter School, Copenhagen |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://neurograd.ku.dk/neurograd-winter-school/ |
| Description | Genomic clues to neurodegenerative disease mechanisms |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Brain Prize Special Lecture/ keynote lecture at ECNP Congress in Copenhagen |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomics of Neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture - 3rd Rijeka Forum on Neurodegenerative diseases, Croatia Rijeka |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genomics of neurodegenerative disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote speaker FENS The Serbian Neuroscience Society. with the Neuroscience societies of Romania and Turkey. Belgrade Serbia. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Glasgow Neuroscience Day: Genomic analysis of neurodegenerative disease |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a teaching lecture to Glasgow University graduates and undergraduates. The keynote lecture sparked questions and discussion afterwards |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.eventbrite.co.uk/e/glasgow-neuroscience-day-2016-tickets-19579056485?aff=erellivcat |
| Description | Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center talk entitled: Genomic analysis of neurodegenerative diseases implicates failures of damage clearance with Q&A |
| Year(s) Of Engagement Activity | 2021 |
| Description | Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker to Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021. Talk entitled: Whole genome analysis of neurodegeneration |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.hksaneuroscience.org/apnsc-hksan-programme |
| Description | INTERVIEW with- Camilla De Fazio - Popular Science about the FDA approval of the first new drug for Alzheimer's disease - |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | INTERVIEW with- Camilla De Fazio - Popular Science about the FDA approval of the first new drug for Alzheimer's disease |
| Year(s) Of Engagement Activity | 2021 |
| URL | http://www.popsci.it/approvazione-di-aducanumab-contro-lalzheimer-una-svolta-tra-molte-incertezze.ht... |
| Description | Inaugural Baillieu Myer Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Inaugural Baillieu Myer Lecture, in honour of contribution to medical research, in particular dementia research |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview with USA Today Health Reporter Ken Alltucker |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with USA Today Health Reporter Ken Alltucker about results of new Alzheimer drug trials |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited Interview/Q&A - Biomarkers for neurodegenerative diseases |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Cars and Scientists short film series, now supported by Jackie Stewart's charity Race Against Dementia |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.raceagainstdementia.com/research/accelerating-research/ |
| Description | Invited Round table public talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited public round table - Brain Prize Evening - Lundbeck - BNA Festival, The Convention Centre Dublin |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited Speaker - 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker to 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY Talk entitled: Genetic analysis of decline of disease rate |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://uniri.hr/wp-content/uploads/2021/11/Simpozij-49_finalno.pdf |
| Description | Invited Speaker 30th Adler Symposium on Alzheimer's Disease |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Goal of the Symposium The 30th anniversary Adler Symposium will focus on issues that are directly relevant to Alzheimer's disease (AD) or on therapies for other disorders that may impact AD. There are four major themes: 1) AD diagnostics and therapeutics; 2) Non-AD therapies that could impact our thinking about AD; 3) Role of genetics, epigenetics, and innate immunity in AD; 4) Brain cell senescence and systemic factors that influence neurodegeneration. The overall format of the meeting should also provide plentiful opportunities for informal interchanges among all the speakers and participants. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited lecture - Alector Seminar and round table |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited speaker entitled: Genomic analysis of neurodegeneration implicates proteostasis as the key problem in late-onset disease followed by round-table discussions |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker - The Genetics Society of Korea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited Plenary Speaker to The Genetics Society of Korea |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.illumina.com/content/illumina-marketing/spac/en_AU/events/conferences/2021/icgsk-2021.ht... |
| Description | Invited speaker NIH Clinical Neuroscience Grand Rounds Main Lecture Speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker talk entitled: Genomic Analysis of the Major Neurodegenerative Diseases - NIH Clinical Neuroscience Grand Rounds with Q&A |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited speaker to 45th FEBS Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk entitled: Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk at 45th FEBS conference |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://2021.febscongress.org/ |
| Description | Invited speaker to The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD) Eisai-sponsored Satellite symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk entitled:The biological and genetic evidence of the Aß pathway The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD) Eisai-sponsored Satellite symposium |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://adpd2021.kenes.com/ |
| Description | Invited talk to the Elderly |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited speaker at Chinese Dementia Meeting at Community Elder Center at Hebei, China |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course: Genomic analysis of neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course - Genomic analysis of neurodegeneration Wellcome Genome Campus in person Hinxton, Cambridgeshire |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://coursesandconferences.wellcomeconnectingscience.org/event/molecular-neurodegeneration-and-th... |
| Description | Keynote Speaker of the Karolinska Institute StratNeuro Neuroscience Symposium 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker - talk title: Genomics of neurodegeneration |
| Year(s) Of Engagement Activity | 2018 |
| Description | MS and Leucodystrophies meeting 33 Queen Square: Are MS and Leukodystrophies a continuum? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a meeting to get two research communities (Multiple Sclerosis and Leukodystrophy) to meet and hopefully set up collaborations. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Meet the Professors |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Round table public talk |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meeting EMBO - Basal Life |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Plenary session 4 Genes to disease and therapies - René Bernards, Botond Roska, Christine Petit, John Hardy |
| Year(s) Of Engagement Activity | 2017 |
| Description | Neanderthals - talk for The National Trust |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture in response to a request to talk to a regional National Trust membership |
| Year(s) Of Engagement Activity | 2019 |
| Description | Opening lecture: Alzheimer's disease: a personal view on early diagnosis and treatment |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - XVIII Teófilo Hernando's International Summer School of Pharmacology Frontier Biomarkers and Drug Discovery for the Early Diagnosis and Treatment of Alzheimer's Disease |
| Year(s) Of Engagement Activity | 2019 |
| Description | PSP & CBD International Research Symposium 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Insights into the genetics of PSP |
| Year(s) Of Engagement Activity | 2018 |
| Description | Progress in the genomic analysis of neurodegeneration |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture to the department of Neurodegenerative Disease as an update on work in progress |
| Year(s) Of Engagement Activity | 2019 |
| Description | Rethinking PD: From a Single Disease to Multiple Diseases:: Genetics, Epigenetics and Environmental Factors |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture by The Preuss Foundation Seminar on State of the Art Parkinson's Disease Research ~ La Jolla, California |
| Year(s) Of Engagement Activity | 2019 |
| Description | Salk Institute for Biological Studies, La Jolla, California: Adler Symposium on Alzeimer's Disease: "25 years of Alzheimer's Disease: Where did it start, and where are we going?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Alzheimer working group |
| Year(s) Of Engagement Activity | 2016 |
| Description | Session 4 - Panel discussion: 'The Future of Neuroscience' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture - UCL Neuroscience Symposium 10th Anniversary, UCL Institute of Education |
| Year(s) Of Engagement Activity | 2019 |
| Description | Skype 2 hour lecture to students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Teaching Lecture to Masters Students "Athens International Master's Programme in Neurosciences" University of Athens Department of Biology |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tau therapeutics - Queen Square Tau mini-symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Questions asked following the talk. Emails exchanged with collaborators and potential collaborators. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Teaching lecture UCL - The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching lecture - for the Clinical Neuroscience MSc 33 QS Lecture Theatre |
| Year(s) Of Engagement Activity | 2022 |
| Description | The Roy M. Huffington Distinguished Lecture at Baylor College of Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Speaker - Genomic Analysis of Neurodegeneration |
| Year(s) Of Engagement Activity | 2017 |
| Description | The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited teaching UCL - Basic neuroscience and investigation of Nervous system - CLNE0009 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | The importance of genetics and molecular biology in neurodegenerative diseases |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invitation to Lecture on MRes Translational Neuroscience programme - 7 Queen Square |
| Year(s) Of Engagement Activity | 2019 |
| Description | The role of genetics and genetic testing in PD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture at World Parkinson Coalition 2019 Kyoto, Japan |
| Year(s) Of Engagement Activity | 2019 |
| Description | University Menéndez Pelayo, in the course XVI International School of Pharmacology < |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching session - Understanding Brain Diseases - Alzheimer's Disease |
| Year(s) Of Engagement Activity | 2017 |
| Description | Where is genetics leading us: The future of genetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | UCL Teaching lecture - Neuromuscular Disease MSc/MRes Advanced genetic technologies and clinical applications module invited by David Blundred - Education Unit - Institute of Neurology |
| Year(s) Of Engagement Activity | 2022 |
| Description | invited interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview to discuss the latest study in the Lancet which suggests By 2050, more than 153 million people could have dementia, up from 57 million in 2019, and that more than one in 50 people in Britain will be living with dementia by 2050. Public knowledge The interview in English, around 5min, aired on BBC World TV and ran several times in full. As a reminder BBC world TV has more than 122 million viewers a week and in more than 200 countries. Their website receives more than a billion views a month |
| Year(s) Of Engagement Activity | 2022 |
| Description | invited lecture 25th National Dementia Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | presentation - Alzheimer's disease: from genetic analysis to mechanistic treatments, with Q&A Thursday 9th February |
| Year(s) Of Engagement Activity | 2023 |
| Description | invited speaker - Understanding the endosomal pathway in neurodegeneration' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Royal Society Hooke Discussion Meeting Organised by Professor Peter Cullen, Professor Peter St George-Hyslop FRS, Professor Scott Small and Dr Henne Holstege Understanding the endosomal network in neurodegeneration 21 - 22 November 2022 The Royal Society, London and online |
| Year(s) Of Engagement Activity | 2022 |
| Description | invited speaker 12th European Congress of Neuropathology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Lecture entitled: Clues to the aetiology of neurodegenerative diseases from genomic analysis at 12th European Congress of Neuropathology |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ecnp2020.dk/ |
| Description | talk on Genetics at McGill University in Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited Lecture |
| Year(s) Of Engagement Activity | 2019 |