Optical coherence tomography in infants and children: A normative database and assessment of clinical use
Lead Research Organisation:
University of Leicester
Department Name: Cardiovascular Sciences
Abstract
Our aim is to make optical coherence tomography (OCT) accessible for clinical use in infants and young children.
Optical coherence tomography provides scans of the back of the eye (the retina and optic nerve) in living people with the precision of a microscope. This has contributed, over the last 15 years, to significant progress in the diagnosis and treatment of retina and optic nerve diseases in adults. However, infants and young children have been deprived of the diagnostic progress as they cannot cooperate with conventional OCT.
The normal optic nerve and retina are not mature at birth and undergo significant changes until adulthood. However, to date little is known about the normal postnatal development. There are no normative OCT data for different ages and therefore OCT can currently not be used for children clinically.
The advent of a new hand-held OCT allows scanning of infants, small children and people who cannot cooperate. However, to date there is little knowledge about its clinical use.
Over the last three years, we have used the hand-held OCT successfully to characterise normal retina development and to compare retinal developmental in disease. This allows us to now use OCT for retinal diagnosis in children in Leicester ophthalmology clinics.
Our objective is to improve OCT acquisition methods for children, to visualise for the first time the development of the optic nerve from birth to 6 years of age using the hand-held OCT device and to establish normative data of the retina and optic nerve in 12 different age groups (90 children per group). OCTs will be performed in a large amount of children with normal eyes to establish normative data. We will also scan the optic nerve in various optic nerve diseases in childhood and investigate to what extent OCT can help with diagnosis. For example, we will look at children who have tumours of the optic nerve (optic nerve glioma) or childhood glaucoma (high pressure in the eye with damage to the optic nerve). We will investigate whether vision can be predicted from OCT scans of various optic nerve diseases. We will investigate to what extent the OCT can help to improve monitoring of childhood glaucoma and optic nerve tumours and reduce the number of examinations under anaesthesia. We anticipate that this study will also help us to understand mechanisms of optic nerve anomalies.
We are planning to develop automatic computer programmes to analyse the OCT images obtained during scanning. This will make the use of the OCT easy and user-friendly and enable the use in clinics.
Developmental abnormalities of the optic nerve and childhood optic nerve diseases, such as glaucoma, are leading causes of child blindness. We anticipate that our study will be an important step in validating OCT and making OCT accessible to newborns, infants and young children with optic nerve diseases. The normative database will provide the groundwork for using OCT in children and will be directly available to other OCT users (it will be shared with the OCT Company Bioptigen Inc.). The optimisation of the use of hand-held OCT opens a wide range of settings outside of the traditional ophthalmology or optometry clinics including intraoperative, primary care, developing countries and military medicine.
Optical coherence tomography provides scans of the back of the eye (the retina and optic nerve) in living people with the precision of a microscope. This has contributed, over the last 15 years, to significant progress in the diagnosis and treatment of retina and optic nerve diseases in adults. However, infants and young children have been deprived of the diagnostic progress as they cannot cooperate with conventional OCT.
The normal optic nerve and retina are not mature at birth and undergo significant changes until adulthood. However, to date little is known about the normal postnatal development. There are no normative OCT data for different ages and therefore OCT can currently not be used for children clinically.
The advent of a new hand-held OCT allows scanning of infants, small children and people who cannot cooperate. However, to date there is little knowledge about its clinical use.
Over the last three years, we have used the hand-held OCT successfully to characterise normal retina development and to compare retinal developmental in disease. This allows us to now use OCT for retinal diagnosis in children in Leicester ophthalmology clinics.
Our objective is to improve OCT acquisition methods for children, to visualise for the first time the development of the optic nerve from birth to 6 years of age using the hand-held OCT device and to establish normative data of the retina and optic nerve in 12 different age groups (90 children per group). OCTs will be performed in a large amount of children with normal eyes to establish normative data. We will also scan the optic nerve in various optic nerve diseases in childhood and investigate to what extent OCT can help with diagnosis. For example, we will look at children who have tumours of the optic nerve (optic nerve glioma) or childhood glaucoma (high pressure in the eye with damage to the optic nerve). We will investigate whether vision can be predicted from OCT scans of various optic nerve diseases. We will investigate to what extent the OCT can help to improve monitoring of childhood glaucoma and optic nerve tumours and reduce the number of examinations under anaesthesia. We anticipate that this study will also help us to understand mechanisms of optic nerve anomalies.
We are planning to develop automatic computer programmes to analyse the OCT images obtained during scanning. This will make the use of the OCT easy and user-friendly and enable the use in clinics.
Developmental abnormalities of the optic nerve and childhood optic nerve diseases, such as glaucoma, are leading causes of child blindness. We anticipate that our study will be an important step in validating OCT and making OCT accessible to newborns, infants and young children with optic nerve diseases. The normative database will provide the groundwork for using OCT in children and will be directly available to other OCT users (it will be shared with the OCT Company Bioptigen Inc.). The optimisation of the use of hand-held OCT opens a wide range of settings outside of the traditional ophthalmology or optometry clinics including intraoperative, primary care, developing countries and military medicine.
Technical Summary
Optical coherence tomography (OCT) provides high-resolution scans of the retina and optic nerve and has contributed to significant progress in the diagnosis and treatment of retinal and optic nerve diseases in adults. However, infants and young children have been deprived of the diagnostic progress as they cannot cooperate with conventional OCT.
The advent of a new hand-held OCT (HH-OCT) allows scanning infants and small children. Over the last three years, we have used the HH-OCT successfully to establish progression of normal human retinal development and develop a diagnostic algorithm for nystagmus. However the lack of normative data and knowledge about presentation of diseases prevents wider clinical use. The normal optic nerve is not mature at birth and is likely to undergo significant changes until adulthood. However, to date little is known about the normal postnatal development. Developmental abnormalities of the optic nerve and childhood optic nerve diseases such as glaucoma are leading causes of child blindness.
First, we plan to optimise and acquisition protocols to enable fast and reliable volumetric scans. We then aim to establish a normative database for optic nerve and retina with OCT in infants and children. We will investigate to what extent OCT can help in improving diagnosis of childhood optic nerve disease. We also will explore whether visual acuity can be predicted from OCT scans. We will investigate to what extent OCT can help improve monitoring of childhood glaucoma and optic nerve glioma and reduce the number of examinations under anaesthesia.
Software for automatic segmentation will be developed for easier and faster interpretation of OCT scans.
We anticipate that our study will be an important step in validating and providing access of OCT in young children with optic nerve diseases. The normative database will provide the groundwork for using OCT in young children.
The advent of a new hand-held OCT (HH-OCT) allows scanning infants and small children. Over the last three years, we have used the HH-OCT successfully to establish progression of normal human retinal development and develop a diagnostic algorithm for nystagmus. However the lack of normative data and knowledge about presentation of diseases prevents wider clinical use. The normal optic nerve is not mature at birth and is likely to undergo significant changes until adulthood. However, to date little is known about the normal postnatal development. Developmental abnormalities of the optic nerve and childhood optic nerve diseases such as glaucoma are leading causes of child blindness.
First, we plan to optimise and acquisition protocols to enable fast and reliable volumetric scans. We then aim to establish a normative database for optic nerve and retina with OCT in infants and children. We will investigate to what extent OCT can help in improving diagnosis of childhood optic nerve disease. We also will explore whether visual acuity can be predicted from OCT scans. We will investigate to what extent OCT can help improve monitoring of childhood glaucoma and optic nerve glioma and reduce the number of examinations under anaesthesia.
Software for automatic segmentation will be developed for easier and faster interpretation of OCT scans.
We anticipate that our study will be an important step in validating and providing access of OCT in young children with optic nerve diseases. The normative database will provide the groundwork for using OCT in young children.
Planned Impact
The main beneficiaries from the proposed research will be:
Parents and children through:
- enabling access to optical coherence tomography (OCT) for infants and small children who have suspected optic nerve anomalies. Currently, without normative data for different age groups OCT cannot be used clinically.
- earlier diagnosis will accelerate and facilitate appropriate care pathways for infants and small children, providing them with a more objective and targeting management plan.
- avoiding invasive and costly tests under general anaesthetic for ambiguous diagnoses.
- providing parents with an indication of possible prediction of visual acuity.
- enhanced health and quality of life.
Clinicians, such as ophthalmologists, paediatricians, neurologists, opticians and orthoptists may benefit from:
- a new and better diagnostic tool which can be used in the clinic setting.
- increased knowledge of the diagnosis and monitoring of several childhood diseases. For example in glaucoma and optic pathway glioma OCT may become the primary method by which this diseases are monitored. It is likely that OCT will help to identify specific retinal and optic nerve changes which can help to recognise genetic syndromes or inform genetic treatment.
-automatic segmentation will improve diagnosis and has a large potential also to facilitate adult OCT
Academics through:
- knowledge of normal development of ocular structures.
- study of mechanisms of disease in a novel way and identification of new therapeutic targets.
- Easier analysis of OCT scans with new segmentation software.
Paediatric ophthalmology clinics in the NHS and worldwide both in terms of time and cost through increased effectiveness and minimisation of resources.
The Royal College of Ophthalmologists, the NHS, NICE and other health policy makers by updating or developing guidelines to improve the care of infants and children.
Industry by:
- Increased use and production of hand-held OCTs due to increased applications and availability of normative data for the first time. This is likely to increase quality and reduce costs of hand-held OCTs.
- Easier and faster use of OCT analysis due to new segmentation software will also be applicable to adult OCT machines.
- Commercialisation of the hand-held OCT by Bioptigen Inc. (the company producing this device) for clinical use.
A successful outcome will also improve the likelihood of relevant medical charities to raise funds for similar research.
The optimisation of the use of hand-held OCT opens a wide range of settings outside of the traditional ophthalmology or optometry clinics including intraoperative, primary care, developing countries and military medicine.
Our proposed project is in line with priority areas 2, 4, 5 and 6 from Fight for Sight research priorities (http://fightforsight.org.uk/research-overview) as well as disease specific priorities (Childhood onset eye disorders, priorities 2, 4, 5, 6; glaucoma priorities 3, 6; neuro-ophthalmology, priority 6 and refractive errors and ocular motility, priority 2) (http://fightforsight.org.uk/tl_files/Documents/Sight-Loss-PSP/SLV-PSP_Final_Report_WEB.pdf). These priorities have been set by consultation with patients and clinicians.
Parents and children through:
- enabling access to optical coherence tomography (OCT) for infants and small children who have suspected optic nerve anomalies. Currently, without normative data for different age groups OCT cannot be used clinically.
- earlier diagnosis will accelerate and facilitate appropriate care pathways for infants and small children, providing them with a more objective and targeting management plan.
- avoiding invasive and costly tests under general anaesthetic for ambiguous diagnoses.
- providing parents with an indication of possible prediction of visual acuity.
- enhanced health and quality of life.
Clinicians, such as ophthalmologists, paediatricians, neurologists, opticians and orthoptists may benefit from:
- a new and better diagnostic tool which can be used in the clinic setting.
- increased knowledge of the diagnosis and monitoring of several childhood diseases. For example in glaucoma and optic pathway glioma OCT may become the primary method by which this diseases are monitored. It is likely that OCT will help to identify specific retinal and optic nerve changes which can help to recognise genetic syndromes or inform genetic treatment.
-automatic segmentation will improve diagnosis and has a large potential also to facilitate adult OCT
Academics through:
- knowledge of normal development of ocular structures.
- study of mechanisms of disease in a novel way and identification of new therapeutic targets.
- Easier analysis of OCT scans with new segmentation software.
Paediatric ophthalmology clinics in the NHS and worldwide both in terms of time and cost through increased effectiveness and minimisation of resources.
The Royal College of Ophthalmologists, the NHS, NICE and other health policy makers by updating or developing guidelines to improve the care of infants and children.
Industry by:
- Increased use and production of hand-held OCTs due to increased applications and availability of normative data for the first time. This is likely to increase quality and reduce costs of hand-held OCTs.
- Easier and faster use of OCT analysis due to new segmentation software will also be applicable to adult OCT machines.
- Commercialisation of the hand-held OCT by Bioptigen Inc. (the company producing this device) for clinical use.
A successful outcome will also improve the likelihood of relevant medical charities to raise funds for similar research.
The optimisation of the use of hand-held OCT opens a wide range of settings outside of the traditional ophthalmology or optometry clinics including intraoperative, primary care, developing countries and military medicine.
Our proposed project is in line with priority areas 2, 4, 5 and 6 from Fight for Sight research priorities (http://fightforsight.org.uk/research-overview) as well as disease specific priorities (Childhood onset eye disorders, priorities 2, 4, 5, 6; glaucoma priorities 3, 6; neuro-ophthalmology, priority 6 and refractive errors and ocular motility, priority 2) (http://fightforsight.org.uk/tl_files/Documents/Sight-Loss-PSP/SLV-PSP_Final_Report_WEB.pdf). These priorities have been set by consultation with patients and clinicians.
Organisations
- University of Leicester (Lead Research Organisation)
- Leica Microsystems GmbH (Collaboration)
- Wellcome Trust (Collaboration)
- Queen Elizabeth Central Hospital, Malawi (Collaboration)
- UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST (Collaboration)
- Birmingham Children's Hospital (Collaboration)
- University of Bristol (Collaboration)
Publications
Aamir A
(2021)
Discordant phenotypes in twins with infantile nystagmus.
in Scientific reports
Anwar S
(2020)
POTENTIAL UTILITY OF FOVEAL MORPHOLOGY IN PRETERM INFANTS MEASURED USING HAND-HELD OPTICAL COHERENCE TOMOGRAPHY IN RETINOPATHY OF PREMATURITY SCREENING.
in Retina (Philadelphia, Pa.)
Anwar Samira
(2016)
Evaluation of Choroidal Thickness in Preterm Infants using Hand Held Spectral Domain Optical Coherence Tomography (HH SD-OCT).
in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Ather S
(2019)
Aberrant visual pathway development in albinism: From retina to cortex.
in Human brain mapping
Kuht HJ
(2023)
Abnormal foveal morphology in carriers of oculocutaneous albinism.
in The British journal of ophthalmology
Kuht HJ
(2023)
Albinism Associated With Torsional Nystagmus Masquerading as Spasmus Nutans.
in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
Kuht HJ
(2022)
Genotypic and Phenotypic Spectrum of Foveal Hypoplasia: A Multicenter Study.
in Ophthalmology
Kuht HJ
(2020)
SLC38A8 mutations result in arrested retinal development with loss of cone photoreceptor specialization.
in Human molecular genetics
Lee H
(2016)
Pediatric Optical Coherence Tomography in Clinical Practice-Recent Progress.
in Investigative ophthalmology & visual science
| Title | Images of research Exhibition at University of Leicester, 2017 |
| Description | Images of Research is a local competition for staff and students to display the breadth and quality of their research in a single photograph. Aarti's image was shortlisted for exhibition allowing her to communicate important aspects of her work to members of the university and the public |
| Type Of Art | Image |
| Year Produced | 2017 |
| Impact | The exhibition raised interest from new audiences within the university and public to my research. The image chosen for display highlighted important aspects of the project - the difficulties examining very young children, close relationships between members of staff and the use of new technology |
| URL | http://www2.le.ac.uk/institution/researchimages/gallery |
| Description | Live Clinical Symposium: Paediatric Optical Coherence Tomography |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.leica-microsystems.com/science-lab/hand-held-oct-clinical-research-applications/ |
| Description | iii Leicester OCT coourse |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Several paediatric ophthalmologists have decided to acquire hand-held OCT instrument which will make changes in their clinical practice. |
| Description | Early Recognition of Raised Intracranial Pressure in Craniosynostosis using Handheld Optical Coherence Tomography |
| Amount | £345,379 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 10/2020 |
| End | 09/2023 |
| Description | • A new approach to optical coherence tomography image analysis using machine learning (PI Bai Li - University of Nottingham) |
| Amount | £185,789 (GBP) |
| Funding ID | BB/P027105/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 02/2019 |
| Title | FDA approved dataset for retinal and optic nerve development - ongoing |
| Description | A highly curated dataset has been developed by the Ulverscroft Eye Unit for clinical and research use. This is currently undergoing the process for FDA approval |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | In progress |
| Title | Premature Infant Retinal Development |
| Description | As part of the current award Dr Aarti Patel is collecting retinal images of infants born prematurely. To my knowledge it is the largest collection in the world and will provide very useful information for current and future clinical and research work. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Data generated will be published to reach a wide international clinical audience once complete. |
| Title | normative database for OCT parameters for children |
| Description | We have collected over 1000 OCTs of retinae and optic nerves of children for a large normative database |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | We have collected the database and are now in the process to analyze and publish normative data Normative data have been published partially for normal retina and optic nerve development |
| Description | Artificial Intelligence in Ophthalmology with Leica Microsystems |
| Organisation | Leica Microsystems GmbH |
| Country | Germany |
| Sector | Private |
| PI Contribution | Application of Artificial Intelligence in Paediatric Ophthalmology we established a collaboration with one of the leading OCT handheld manufacturer - Leica Microsystems. We have been collecting OCT data to develop an AI software for automated classification of scans. |
| Collaborator Contribution | Leica Microsystems have been providing an advisory/mentorship role. They have also provided technical assistance and released a prototype software for our use. This provides us access to the encrypted files used on their OCT technology |
| Impact | Main output: Novel AI algorithm Multi-disciplinary - with the School of Informatics (University of Leicester, UK), Machine Learning Lab (IIIT, Hyderabad, India), Ophthalmology (University of Leicester, UK). Additional Outputs: Title: Using Artificial Intelligence to Distinguish Between Normal and Abnormal Development of the Fovea Conference: British Congress of Optometry and Visual Science (BCOVS) Date: 07/09/2020 Prize: Best Presentation (Miss H Kuht) Title: Using Artificial Intelligence (AI) to Differentiate between Normal and Abnormal Retinal Development Conference: Kettering Eye Meeting Date: 11/09/2020 Title: Using Artificial Intelligence (AI) to Differentiate between Normal and Abnormal Retinal Development. Conference: Midlands Ophthalmological Society Date: 02/10/2020 Prize: Best Academic Presentation Prize (Dr M Thomas) Title: Using Artificial Intelligence to Differentiate between Normal and Abnormal Retinal Development Conference: European Days in Albinism Date: 4-7/11/2020 |
| Start Year | 2018 |
| Description | Changes of retinal layers in Schizophrenia |
| Organisation | University Hospitals of Leicester NHS Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Initiate collaboration, research set up, supervision, ophthalmic examination, OCT acquisition and analysis, manuscript writing, statistics |
| Collaborator Contribution | Patient recruitment and psychiatric examination of patients, manuscript revision |
| Impact | Retinal Layer Abnormalities as Biomarkers of Schizophrenia. Samani NN, Proudlock FA, Siram V, Suraweera C, Hutchinson C, Nelson CP, Al-Uzri M, Gottlob I. Schizophr Bull. 2017 Dec 19. doi: 10.1093/schbul/sbx130. [Epub ahead of print] |
| Start Year | 2016 |
| Description | Clinical teaching on the Use of Hand-held Optical Coherence Tomography |
| Organisation | Leica Microsystems GmbH |
| Country | Germany |
| Sector | Private |
| PI Contribution | Several members of the team including Frank Proudlock, Mervyn Thomas and Zhanhan Tu have collaborated with Leica Microsystems to generate a live clinical symposium on the use of hand-held optical coherence tomography. |
| Collaborator Contribution | The session was hosted by Leica Microsystems |
| Impact | Attendance of this session was over 200 participants with representatives from all over the globe. The session was useful in informing clinicians on the applications of hand-held optical coherence tomography in the clinic and practical ways of using this technique. |
| Start Year | 2020 |
| Description | Collaboration with Birmingham Children's Hospital |
| Organisation | Birmingham Children's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We have contacted the Birmingham team and planned to recruit patients from their clinics. We have developed specific techniques to acquire and analyse of anterior and posterior hand-held OCT from these young children with complex problems. |
| Collaborator Contribution | The partners examine very complex patients in clinic such as paediatric glaucoma, craniosynostosis, retinoblastoma, rare retinal and optic nerve diseases and phenotypr these patients. |
| Impact | Detection and characterisation of optic nerve and retinal changes in primary congenital glaucoma using hand-held optical coherence tomography. Pilat AV, Shah S, Sheth V, Purohit R, Proudlock FA, Abbott J, Gottlob I. BMJ Open Ophthalmol. 2019 Jun 24;4(1):e000194. doi: 10.1136/bmjophth-2018-000194. eCollection 2019. PMID: 31321308 Free PMC Article Similar articles |
| Start Year | 2016 |
| Description | Collaboration with Queen Elizabeth Hospital, Blantyre, Malawi |
| Organisation | Queen Elizabeth Central Hospital, Malawi |
| Country | Malawi |
| Sector | Hospitals |
| PI Contribution | We have done preliminary hand-held OCT scanning in patients with cerebral malaria and malaria retinopathy on admission in the acute stage. We have determined specific signs for malarial retinopathy. We also have obtained long-term follow-up. Comparison between OCT parameters, clinical presentation and MRI are being made. |
| Collaborator Contribution | Characterisation of patients. Facilitating the study |
| Impact | Hand-held Optical Coherence Tomography - A New Biomarker of Brain Swelling in Cerebral Malaria OPEN ACCESS Zhanhan Tu; Viral Sheth; Jack Gormley; Chatonda Manda; Frank A Proudlock; Karl Seydel; Terrie Taylor; Simon P Harding; Irene Gottlob Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):612. doi: https://doi.org/ |
| Start Year | 2016 |
| Description | Collaboration with the University of Bristol |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | e established collaboration to increase the collection of normative data. We provided collaborators in Bristol with know how about the hand-held OCT |
| Collaborator Contribution | Recruitment of normal subjects for OCT scanning |
| Impact | in preparation |
| Start Year | 2017 |
| Description | Use of hand-held OCT in children with malaria retinopathy |
| Organisation | Wellcome Trust |
| Department | Malawi-Liverpool Wellcome Trust Clinical Research Programme |
| Country | Malawi |
| Sector | Academic/University |
| PI Contribution | Expertise in hand-held OCT, equipment (hand-held OCT has been transported to Malawi and is still there), lead by our team to collect data. We have examined for the first time children with cerebral malaria using hand-held OCT in Malawi to investigate if specific retinopathy changes can predict course of disease and to what extend OCT can contribute to characterise the retinal changes at high resolution. We have characterised the retinal changes on OCT and compared them with fundus pictures, fluorescein angiography and histology. We have looked at optic nerve changes and correlated swelling to opening pressure at lumbar puncture and found correlation. Publication is in preparation |
| Collaborator Contribution | We have examined for the first time children with cerebral malaria using hand-held OCT in Malawi to investigate if specific retinopathy changes can predict course of disease and to what extend OCT can contribute to characterise the retinal changes at high resolution. We have characterised the retinal changes on OCT and compared them with fundus pictures, fluorescein angiography and histology. We have looked at optic nerve changes and correlated swelling to opening pressure at lumbar puncture and found correlation. Publication is in preparation. Our partners have done treatment and all paediatric examinations. |
| Impact | http://ARVO Annual Meeting Abstract June 2017 New insights into malaria retinopathy using optical coherence tomography OPEN ACCESS Jack Gormley; Zhanhan Tu; Viral Sheth; Frank A Proudlock; Karl Seydel; Terrie Taylor; Gerald Msukwa; Nicholas V Beare; Simon P Harding; Irene Gottlob Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5134. doi: Subclinical changes on hand-held optical coherence tomography in apparently malaria retinopathy-negative patients with cerebral malaria OPEN ACCESS Zhanhan Tu; Jack Gormley; Viral Sheth; Frank A Proudlock; Karl Seydel; Terrie Taylor; Gerald Msukwa; Nicholas V. Beare; Simon P Harding; Irene Gottlob Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5135. doi: |
| Start Year | 2016 |
| Title | Development of an FDA Approved Normative Paediatric Clinical Dataset to Improve the Diagnosis of Eye Diseases in Children |
| Description | At the present the normative dataset in being developed in collaboration between the University of Leicester and Translational Imaging Innovations (https://tiinnovations.com/, USA), to gain approval for use as a clinical diagnostic device by gaining FDA approval of the dataset. To accomplish the dataset is undergoing a series of validation steps as well as clean up and sorting of the data. |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2021 |
| Development Status | Under active development/distribution |
| Impact | As this normative dataset has wide applicability to many paediatric eye diseases the potential benefits of this dataset are far reaching. |
| Description | ImageJ macro to analyse manually a b-scan of optic nerve head structure. Specifically for 8x12 protocol used by Patel et al., 2016 (10.1016/j.ophtha.2016.06.057)Requires:1. ABSnake plugin2. Leica ImageJ plugin to read data3. Set of images to show location of segmented layers |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| URL | https://leicester.figshare.com/articles/software/Leica_ONH_analysis_program_8x12mm_protocol_/1946485... |
| Description | ImageJ macro to analyse manually a b-scan of optic nerve head structure. Specifically for 8x12 protocol used by Patel et al., 2016 (10.1016/j.ophtha.2016.06.057)Requires:1. ABSnake plugin2. Leica ImageJ plugin to read data3. Set of images to show location of segmented layers |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| URL | https://leicester.figshare.com/articles/software/Leica_ONH_analysis_program_8x12mm_protocol_/1946485... |
| Description | "Big Bang" Science and Technology fair at Leicester Grammar School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A visit with demonstating the Hand-hel OCT and explaining anatomy and physiology of the eye and research popportunities |
| Year(s) Of Engagement Activity | 2019 |
| Description | A talk or presentation - Participation in 5th European Days of Albinism (EDA) for people with albinism and researchers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This is the largest albinism patient and researcher meeting which was held virtually this year (2020). The research group presented a range of different talks including (related to this award): 1. Phenotypic Characteristics as a Diagnostic Tool for Albinism: Sensitivity and Specificity Analysis 2. Phenotypical characteristics in albinism carriers 3. Using artificial intelligence to distinguish between normal and abnormal retinal development This raised interesting discussion about diagnostic criteria and the need for the development of consensus guidelines. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://5eda.albinism.eu/ |
| Description | American Nystagmus Network Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | I gave a presentation on the effect of nystagmus (in Washington DC, USA) on vision for daily living mainly to people with nystagmus and their health care professionals |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://nystagmus.org/new/conferences/previous-conferences/2019-conference/ |
| Description | Anterior Optical Coherence Tomography in Children with Primary Congenital Glaucoma< ARVO, May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Attendance of American Nystagmus Network patient and researcher conference, New Orleans, USA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The purpose of the visit was to be involved in a combined researcher and patient meeting to share with sufferers of nystagmus some of the research we have been doing and to offer expert opinions. The visit also enabled researchers to hear from patients about what really impacts upon their life as individuals with nystagmus and express their views concerning where further research needs to be carried out. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://nystagmus.org/new/conferences/previous-conferences/2015-conference/ |
| Description | Attendance of European Days of Albinism (EDA) patient and researcher conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The European Days of Albinism (EDA) are organised to bring together researchers and patients under the one roof to share information and establish links. The meeting involves research talks which are then summarised to the patients which attend from all over the world. The meeting also provides an opportunity for individuals with albinism to share their experienced and to hear about difficulties encountered from individuals across the globe. This includes those who suffer persecution as a result of having albinism. The meeting offers education to researchers and patients alike. |
| Year(s) Of Engagement Activity | 2014,2016 |
| URL | http://www.ledha.it/allegati/LED_t2_notizie_allegati/2171/FILE_Allegato_Albinism_DEF_19022016.pdf |
| Description | BIPOSA prize |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This prestigious price was won by a trainee in our team for presenting "The prediction of later visual acuity in nystagmus from OCT early in life) |
| Year(s) Of Engagement Activity | 2009 |
| URL | https://www2.le.ac.uk/colleges/medbiopsych/research/clinical-academic-training/trainee-achievements/... |
| Description | Big Bang Science air - Leicester Grammar School |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We had a stand at the Science Day of Leicester Grammar School about our research and the connection of the eye and brain. We also offered a retinal scan with the handheld OCT to students. There was large interest with queues forming in front of our station. After the event we had many emails and phone calls to enquire study collaborations by parents in the school who are medical doctors or scientists. Families who could not be scanned on the day are keen to come in our department to help with normative data. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Brain Awareness Day 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Involvement in demonstration of hand-held optical coherence tomography to schools and members of the public attending the Brain Awareness Day. Poster used to describe amblyopia research and engage the public. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2017,2018,2019 |
| URL | https://www2.le.ac.uk/departments/npb/news-1/baw |
| Description | Brain Awareness Day, University of Leicester, March 2017 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Research made lay for the general public, increase awareness in Brain/eye research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Brain awareness Day University of Leicester |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | The demonstration was called: "The developing eye - using light to explore the retina". It was given at the Brain awareness day and there was one session for school children and one for the general public. The hand-held OCT was used to demonstrate how the retinal layers and the optic nerve can be visualised. Thee were also short talks to explain how the OCT can be used for patients and for observing normal retinal / optic nerve development. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Brain awareness day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Demonstration of the Hand-Held OCT to the public and school classes |
| Year(s) Of Engagement Activity | 2019 |
| Description | British and Irish Paediatric Ophthalmology and Strabismus (BIPOSA) society meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of work at the largest paediatric ophthalmology meeting in UK (October 2-4, 2019). This raised significant interest and engagement from other healthcare practitioners from across UK and validation of the need for this research. Team member (HK), received best oral presentation prize. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.biposa.org/ |
| Description | Can grading foveal hypoplasia in infants using handheld optical coherence tomography predict future visual acuity? A longitudinal cohort study, ARVO May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Careers Fair at Leicester Grammar School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Aarti was invited to participate in a local careers fair for senior school students. During the event she spoke about a career in academic medicine and has subsequently helped students organise work experience within the department and guided them through the medical school application process. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Co-organisation of ARVO Annual Meeting and Lecture Baltimore |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Comparison of retinal development in idiopathic infantile nystagmus and nystagmus associated with albinism, PAX6 mutations and achromatopsia, ARVO May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Contribution of Central and Peripheral Visual Cues to Postural Control in Infantile Nystagmus, ARVO, May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | High School Vision Program (Diversity Initiatives and Committee) event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | School children were invited to attend a special event at The Association for Vision and Ophthalmology Annual Meeting in Baltimore May 2017. Aarti volunteered to help giving individuals a tour of the event and discussing her own and other research activities. She looks forward to taking part again in 2018. |
| Year(s) Of Engagement Activity | 2017 |
| Description | International OCT course in Leicester |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a 2 day OCT course , the first day was hands on with practical teaching to enable other practitioners to acquire OCT images. Patients (children) attended to allow to develop practical skills. The second day included dissemination of the latest research results and how they can be applied in clinic. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.le.ac.uk/departments/npb/news-1/oct-course |
| Description | Interview for national optometry magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Approached to be interviewed for an optometry magazine (Optometry Today) to inform the profession of our proposed innovation and the potential impact. This was well received and subsequently had various practitioners requesting more information about our research |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.aop.org.uk/ot/in-practice/practitioner-stories/2020/05/09/we-are-beginning-to-appreciate... |
| Description | Invited Keynote talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Invited Keynote (by team member HK) talk for 100% Optical in ExCeL, London (January 25-27, 2020) (100% Optical is the UK's largest optical event, bringing together 9,115 professionals) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited Lecture EUNOS 2017 Budapest |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at EUNOS annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Lecture SOE 2017 Barcelona |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation SOE annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Presentation - Optic Nerve Changes in Children with Primary Congenital Glaucoma, BIPOSA, Hull, 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at BIPOSA meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Presentation - Optic Nerve Head Drusen and IIH, Northampton Eye Meeting, Northampton, 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at Northampton eye meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Presentation - Optic Neuropathy in Children with Primary Glaucoma, ARVO 2017 Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited lecture - European Neuro-ophthalmology Society Porto |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture on normal development of retina and pathology investigated by hand-held OCT |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecture European Society of Ophthalmology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture on normal development of retina and pathology investigated by hand-held OCT |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited lecture European Strabological Association |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited lecture on normal development of retina and pathology investigated by hand-held OCT |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited public lecture for Brain awareness week at the University of Leicester 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Brain Awareness Week (BAW) is the global campaign to increase public awareness of the progress and benefits of brain research. I was invited to give the public lecture for this event on my research and how it impacts patients. This event was held at the prestigious George Davies Centre, Lancaster Road, on Wednesday, 13th March 2019. This event was attended by A-level and GCSE students, members of the public, as well as University staff, students, their friends and families. The event attracted more than 200 people. Along with my talk there will was live demonstrations of the research I was involved in and the opportunity to meet current students, researchers and neuroscientists. It raised the awareness of my research and engaged with >100 schools students and members of the general public. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www2.le.ac.uk/departments/npb/news-1/baw/BAW |
| Description | Invited talk or presentation - Scientific Committee meeting - 5th European Days of Albinism (EDA) for people with albinism and researchers |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented development of international guidelines for the diagnosis and management of albinism to the albinism scientific committee. Other invited members included patient organisations and their respective representatives. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://5eda.albinism.eu/ |
| Description | Leicester Grammar Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Participation in workshop to Leicester Grammar School which sparked questions and discussions afterward. Aim was to increase awareness about research in Ophthalmology |
| Year(s) Of Engagement Activity | 2017 |
| Description | Leicester OCT Course Demonstration and Case Report |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at the Leicester OCT Course |
| Year(s) Of Engagement Activity | 2017 |
| Description | New insights into malaria retinopathy using optial coherence tomography, ARVO, May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Normative Recruitment Presentation at Tongren Eye Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation on recruitment of patients for OCT testing |
| Year(s) Of Engagement Activity | 2018 |
| Description | Nursery Visit - Stanhope Nursery, Leicester 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Recruitment for OCT Testing |
| Year(s) Of Engagement Activity | 2017 |
| Description | Nursery Visit, Play Days Nursery, Leicester 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Recruitment of children for OCT testing for research grant |
| Year(s) Of Engagement Activity | 2017 |
| Description | Nursery Visit, Willows Pre-School, 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Recruitment of children for OCT testing at Leicestershire nursery |
| Year(s) Of Engagement Activity | 2018 |
| Description | Nystagmus Network (2019) - Patient and researcher two day workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | This was a workshop and patient outreach event organised by Nystagmus network. This allows researchers and patients/carers to interact and discuss research and patient priorities. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://nystagmusnetwork.org/uk-nystagmus-research-workshop/ |
| Description | Nystagmus Network UK Research Workshop 2021 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | This activity was run to update the members of Nystagmus Network UK of the research developments that have taken place in Leicester, UK on nystagmus research. In addition, the update was also given to other university departments who are also carrying out nystagmus research. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Optic Nerve Head Development of Premature and Full Term infants from Term to Six Years of Age Using Hand-Held Ultra-High Resolution Spectral Domain Coherence Tomography, ARVO, May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Organisation of BINOC Conference Rutland 2017 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at BINOC annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Organisation of Paediatric OCT Course Leicester 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at Paediatric OCT Course with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Paediatric OCT Course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OCT course in Leicester with international attendance |
| Year(s) Of Engagement Activity | 2017 |
| Description | Paediatric and World Ophthalmology Registrars Prize |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Paediatric and World Ophthalmology Registrar's Prize |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.le.ac.uk/offices/press/press-releases/2017/july/university-of-leicester-researcher-wins... |
| Description | Participation in Brain Awareness Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Involvement in demonstration of hand-held optical coherence tomography to schools and members of the public attending the Brain Awareness Day. Poster used to describe amblyopia research and engage the public. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www2.le.ac.uk/departments/npb/news-1/baw |
| Description | Participation in Brain Awareness Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Involvement in demonstration of hand-held optical coherence tomography to schools and members of the public attending the Brain Awareness Day. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| URL | http://www2.le.ac.uk/departments/npb/news-1/baw |
| Description | Participation in IV European Days of Albinism (EDA) in Norway (near Oslo) for people with albinism and researchers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The European Days of Albinism (EDA) are organised to bring together researchers and patients under the one roof to share information and establish links. The meeting involves research talks which are then summarised to the patients which attend from all over the world. The meeting also provides an opportunity for individuals with albinism to share their experienced and to hear about difficulties encountered from individuals across the globe. This includes those who suffer persecution as a result of having albinism. The meeting offers education to researchers and patients alike. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://4eda.albinism.eu/ |
| Description | Participation in Wobbly Wednesday |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Wobbly Wednesday is a day run by Nystagmus Network UK to raise public awareness of nystagmus and assist with fund raising. |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | http://nystagmusnetwork.org/fundraise/wobbly-wednesday/ |
| Description | Patient Public Involvement - questionnaire |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | Aarti has utilised written correspondence to communicate with participants of the study including cards, questionnaires and newsletters. Questionnaires have enabled her to canvass patient opinion of the study. Cards and newsletters have enabled her to maintain relationships with participants and disseminate research findings. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Patient engegement - Nystagmus Network UK |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Talk at the open day of the Nystagmus Network UK about the use of hand-held OCT in Nystagmus. Discussions with patients and parents |
| Year(s) Of Engagement Activity | 2019 |
| Description | Postgraduate Research Day, Clinical Characteristics of Albinism Carriers, Leicester, 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research day for Postgraduate students |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at The British Congress of Optometry and Visual Science (BCOVS) 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The British Congress of Optometry and Visual Science (BCOVS) is a multi-disciplinary meeting showcasing the work of optometrists, orthoptists, ophthalmologists and vision scientists across the UK, India and Australia. Team member (HK) presented the work: "Development and validation of a deep learning algorithm to differentiate between normal and abnormal retinal development" which sparked a lot of interest and discussion. This work received the best presentation prize. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://bcovs2020.wordpress.com/programme/ |
| Description | Presentation at the Houses of Parliament - STEM for Britain event (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Early career researcher and team member (HK) was invited to present in the Houses of Parliament during British Science Week at the STEM for Britain event (March 9, 2020). This involved engaging with politicians and discussing the impact and implications of the work "Using Artificial Intelligence to Distinguish Between Normal and Abnormal Development of the Fovea". Broader discussions about how AI would augment clinical practice and its role in healthcare was of much interest for politicians and policymakers. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://stemforbritain.org.uk/ |
| Description | Reproducibility of measurements of iridocorneal angle in children using hand-held spectral domain optial cohrence tomography, ARVO, May 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Roger Trimble Lecture 2017 Irene Gottlob |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a named lectured for service in Paediatric Ophthalmology at the BIPOSA meeting |
| Year(s) Of Engagement Activity | 2007 |
| URL | http://www.biposa.org/trimble-lecturers.html |
| Description | School Visit (Leicester Grammar School) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Big Bang Science Fair held by Leicester Grammar School is a one day event showcasing science, technology engineering and maths. Aarti organised attendance and participation of Ulverscroft Eye Unit which involved demonstrating clinical and research aspects of her work, |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.leicestergrammar.org.uk/Big-Bang |
| Description | Subclinical changes on hand-held optical coherence tomography in apparently malaria retinopathy-negative patients with cerebral malaria, ARVO, May 2017, Baltimore USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk/presentation at ARVO annual meeting with questions and discussion |
| Year(s) Of Engagement Activity | 2017 |
| Description | Third Leicester OCT course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OCT course to teach how to use hand-held OCT including hands on course and practical activities. |
| Year(s) Of Engagement Activity | 2016 |
| Description | University of Alabama Invited talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | An invited lecturer about OCT and other visual deficits in albinism |
| Year(s) Of Engagement Activity | 2018 |
| Description | Visit to Capitol Hill, Washington DC for ARVO Advocacy Day |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | As part of The Association for Research in Vision and Ophthalmology (ARVO) programming committee I attended an advocacy day to campaign for continued support for vision and eye research from the US government through funding via the Institute of Health (and the National Eye Institute). The ARVO committee wanted to use optical coherence tomography as an example of success leading to improved treatment, diagnosis and ultimately saving money for health services worldwide. I was able to use the research carried out with hand-held optical coherence tomography as funded by the MRC to highlight this point. The congressmen and senators and their office received this information enthusiastically and were particularly interested in its use in child health where it has the potential to improve diagnosis and treatment from birth onwards. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.arvo.org/Advocacy_and_Outreach/toolkits/ |
| Description | invited lecture and discussion - American Nystagmus Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Invited lecture to US Nystagmus Network. Talk and discussions with patients |
| Year(s) Of Engagement Activity | 2019 |
| Description | science fair |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | We had a stand at the Science Fair of Leicester Grammar School. There have been about 600 students and visitors as well as their parents. We have made the public aware of our research and also recruited study participants. On this day we have recruited 40 children and we have distributed flyers to raise awareness of our study and for further families to participate and to visit us at the University. |
| Year(s) Of Engagement Activity | 2017 |