Understanding prevalence and impact of frailty in chronic illness and implications for clinical management
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
People who are more likely to become seriously unwell following relatively minor events (e.g. infections) are said to have "frailty". Frail people are more susceptible to harms, for example, from having diagnostic tests or side-effects of medications. Compared to people without frailty, this makes it harder to deliver the best care.
Although older people are more likely to be frail, not all older people are frail. Younger people can also be affected by frailty, especially those with chronic illness such as diabetes. However, there is very little evidence about how clinical management should be adjusted in people with frailty, particularly younger people.
A major gap in evidence relates to clinical trials. Clinical trials are the most important source of evidence about the effectiveness of treatments (e.g. a particular drug). It is generally believed that frail people are less likely to be included in trials. However, since trials do not usually measure frailty we do not currently know how often frail people are included, or if frail trial participants are similar to people in the community with frailty. This leaves clinicians uncertain about whether they can use the evidence from trials when deciding which treatments to offer frail people.
A second challenge in managing frailty concerns "self-management", which is something everyone who has a chronic illness needs to learn. Self-management involves people balancing their condition (e.g. diagnostic tests, attending appointments, accepting treatments) against other priorities in their lives, given their own capacity and resources (e.g. financial circumstances, social support, other commitments). It is likely that self-management is more difficult for frail people. However, no previous study has reviewed all the published research to see if and how the presence of frailty should change the way health professionals support self-management.
We plan to address both evidence-gaps.
Aim
To identify and measure frailty in clinical trials, as well as in community settings, to assess how best to apply evidence from trials when deciding what treatments to offer people with frailty and chronic illness. Secondly, we will undertake a detailed review of published research to determine how to support self-management in the presence of frailty.
As examples, we will study data from people with three important and common long-term conditions: type 2 diabetes, rheumatoid arthritis, and chronic obstructive pulmonary disease
Objectives
For type 2 diabetes, rheumatoid arthritis, and chronic obstructive pulmonary disease:
1. To estimate how common frailty is, in both the community and in participants in clinical trials
2. To examine the relationship between frailty and deteriorating health (e.g. increasing breathlessness, increased hospitalisation), for both community and clinical trial settings
3. To assess whether the effectiveness of drug treatments is different for people with and without frailty
And for type 2 diabetes
4. To review published research on self-management, to determine how best to account for a person's frailty, level of function, and wider social support when supporting self-management.
Potential applications and benefits
This work will improve understanding of the consequences of frailty. It will also develop and test methods for identifying frailty within trials. This will provide insights into how existing evidence applies to frail people.
This project will therefore benefit people with frailty, clinicians, guideline developers, healthcare organisations and health policymakers to understand the implications of frailty and how to best treat people with frailty, and support them to manage their health.
It will also guide the design of future research by determining the extent to which current research (e.g. clinical trials of drugs or self-management approaches) includes people with frailty.
Although older people are more likely to be frail, not all older people are frail. Younger people can also be affected by frailty, especially those with chronic illness such as diabetes. However, there is very little evidence about how clinical management should be adjusted in people with frailty, particularly younger people.
A major gap in evidence relates to clinical trials. Clinical trials are the most important source of evidence about the effectiveness of treatments (e.g. a particular drug). It is generally believed that frail people are less likely to be included in trials. However, since trials do not usually measure frailty we do not currently know how often frail people are included, or if frail trial participants are similar to people in the community with frailty. This leaves clinicians uncertain about whether they can use the evidence from trials when deciding which treatments to offer frail people.
A second challenge in managing frailty concerns "self-management", which is something everyone who has a chronic illness needs to learn. Self-management involves people balancing their condition (e.g. diagnostic tests, attending appointments, accepting treatments) against other priorities in their lives, given their own capacity and resources (e.g. financial circumstances, social support, other commitments). It is likely that self-management is more difficult for frail people. However, no previous study has reviewed all the published research to see if and how the presence of frailty should change the way health professionals support self-management.
We plan to address both evidence-gaps.
Aim
To identify and measure frailty in clinical trials, as well as in community settings, to assess how best to apply evidence from trials when deciding what treatments to offer people with frailty and chronic illness. Secondly, we will undertake a detailed review of published research to determine how to support self-management in the presence of frailty.
As examples, we will study data from people with three important and common long-term conditions: type 2 diabetes, rheumatoid arthritis, and chronic obstructive pulmonary disease
Objectives
For type 2 diabetes, rheumatoid arthritis, and chronic obstructive pulmonary disease:
1. To estimate how common frailty is, in both the community and in participants in clinical trials
2. To examine the relationship between frailty and deteriorating health (e.g. increasing breathlessness, increased hospitalisation), for both community and clinical trial settings
3. To assess whether the effectiveness of drug treatments is different for people with and without frailty
And for type 2 diabetes
4. To review published research on self-management, to determine how best to account for a person's frailty, level of function, and wider social support when supporting self-management.
Potential applications and benefits
This work will improve understanding of the consequences of frailty. It will also develop and test methods for identifying frailty within trials. This will provide insights into how existing evidence applies to frail people.
This project will therefore benefit people with frailty, clinicians, guideline developers, healthcare organisations and health policymakers to understand the implications of frailty and how to best treat people with frailty, and support them to manage their health.
It will also guide the design of future research by determining the extent to which current research (e.g. clinical trials of drugs or self-management approaches) includes people with frailty.
Technical Summary
Aim
To assess the prevalence and importance of frailty using three exemplar non-communicable diseases (NCDs) (type 2 diabetes, rheumatoid arthritis and chronic obstructive pulmonary disease), and to explore implications of frailty for management.
Objectives
-Assess the prevalence of frailty, by age and sex, in each exemplar NCD, comparing general population estimates to participants in randomised controlled trials
-Examine the association between frailty and clinical outcomes
-Explore if the efficacy of drug treatments differs by frailty status
-Assess how self-management should be supported in frail people
Methods
Data will be drawn from large population cohorts as well as individual patient data from phase 3/4 randomised controlled trials. Frailty will be quantified using a frailty index (in trials and population cohorts) and frailty phenotype (cohorts only). The prevalence and degree of frailty in trial populations will be compared to population estimates accounting for age, sex, and clustering inherent in the data. The relationship between frailty and clinical outcomes will be assessed. Where frailty is present in clinical trials, the impact on adverse event rates and relative treatment effectiveness will be analysed using interaction terms.
A systematic review of self-management interventions for type 2 diabetes will explore if interventions account for frailty or functional status, and to what extent this affects outcomes.
Scientific/medical opportunities
Frailty has not previously been studied in clinical trial settings for these conditions. The proposed work will help us better understand prevalence and implications of frailty and also assess the extent to which existing evidence takes account of frailty in target populations. Where frailty is identified, this work will inform the application of clinical evidence to this population. This will allow more accurate estimation of potential risks and benefits and tailoring of interventions.
To assess the prevalence and importance of frailty using three exemplar non-communicable diseases (NCDs) (type 2 diabetes, rheumatoid arthritis and chronic obstructive pulmonary disease), and to explore implications of frailty for management.
Objectives
-Assess the prevalence of frailty, by age and sex, in each exemplar NCD, comparing general population estimates to participants in randomised controlled trials
-Examine the association between frailty and clinical outcomes
-Explore if the efficacy of drug treatments differs by frailty status
-Assess how self-management should be supported in frail people
Methods
Data will be drawn from large population cohorts as well as individual patient data from phase 3/4 randomised controlled trials. Frailty will be quantified using a frailty index (in trials and population cohorts) and frailty phenotype (cohorts only). The prevalence and degree of frailty in trial populations will be compared to population estimates accounting for age, sex, and clustering inherent in the data. The relationship between frailty and clinical outcomes will be assessed. Where frailty is present in clinical trials, the impact on adverse event rates and relative treatment effectiveness will be analysed using interaction terms.
A systematic review of self-management interventions for type 2 diabetes will explore if interventions account for frailty or functional status, and to what extent this affects outcomes.
Scientific/medical opportunities
Frailty has not previously been studied in clinical trial settings for these conditions. The proposed work will help us better understand prevalence and implications of frailty and also assess the extent to which existing evidence takes account of frailty in target populations. Where frailty is identified, this work will inform the application of clinical evidence to this population. This will allow more accurate estimation of potential risks and benefits and tailoring of interventions.
Planned Impact
The proposed research will have broad clinical, societal and academic impacts. Given ageing population demographics; increasing multimorbidity affecting a wide range of ages; and recent findings suggesting frailty can affect middle-aged as well as older people; a greater understanding of frailty is vital to inform clinical care, health service delivery and resource allocation. Frailty impacts both primary and secondary care, as well as a range of clinical specialties, albeit to varying degrees.
Public
Throughout the duration of the fellowship, a key focus will be public engagement, which is why the support and input of the third sector organisation, The ALLIANCE Scotland, which represents people with chronic illness, is so important. We will work with this charity, and others as appropriate, to ensure meaningful dialogue with the public, through means outlined in the communications plan, so that public awareness of the problem of frailty is increased and there is greater understanding of the wider implications of the condition and the challenges it presents to individuals and society. By analysing a broader age-range than most previous frailty research (including people <65 years old), the proposed work will enable wider public engagement and discussion about the meaning of frailty, who it impacts, and how professionals, health systems and the public should respond. Such an approach challenges the popular conception of 'frailty', and a wider public dialogue will be central to the translation of any findings relating to 'middle-aged' frailty into meaningful and acceptable changes to clinical practice, guidelines, or interventions.
Healthcare professionals
The work will also serve to increase professional awareness of the importance of frailty and its implications for clinical practice and clinical guidelines. Through our communications plan we aim to reach out to a range of professionals and expect the findings to influence practitioners' attitudes to frailty, which, depending on findings, might include changing approaches to screening for frailty and influencing methods in future clinical trials, for example, in relation to the way frailty is considered as a key variable.
Health policymakers and guideline developers
Our work will foster improved health and wellbeing of people living with frailty by influencing evidence generation and synthesis as well as clinical guideline development, thereby influencing healthcare policy. Highlighting the impact of frailty on clinical outcomes will better inform the response of clinicians, guideline developers, and policymakers to patients' needs, and help identify high risk patients at whom limited resources may be targeted. Considering how pharmacological and non-pharmacological interventions may be tailored to the context of frailty; variation in risks and benefits; and to what extent frailty is under-represented in existing evidence, will help inform treatment recommendations and clinical guidelines. This may allow more active and informed participation of patients in decisions relating to their care. Findings could inform further analyses exploring economic implications, and the cost-effectiveness of interventions, in the context of frailty.
Researchers and academics
The planned programme of research is novel and so the methodological approaches to evidence generation used in the context of frailty in the three exemplar NCDs may be adapted and refined for other disease contexts, extending the potential reach and relevance of the findings.
In summary, the proposed research will lead to improved management of frailty by generating evidence to inform clinical decision making; increasing awareness of the implications of frailty; and informing future development of interventions to optimise healthcare delivery for frail patients.
Public
Throughout the duration of the fellowship, a key focus will be public engagement, which is why the support and input of the third sector organisation, The ALLIANCE Scotland, which represents people with chronic illness, is so important. We will work with this charity, and others as appropriate, to ensure meaningful dialogue with the public, through means outlined in the communications plan, so that public awareness of the problem of frailty is increased and there is greater understanding of the wider implications of the condition and the challenges it presents to individuals and society. By analysing a broader age-range than most previous frailty research (including people <65 years old), the proposed work will enable wider public engagement and discussion about the meaning of frailty, who it impacts, and how professionals, health systems and the public should respond. Such an approach challenges the popular conception of 'frailty', and a wider public dialogue will be central to the translation of any findings relating to 'middle-aged' frailty into meaningful and acceptable changes to clinical practice, guidelines, or interventions.
Healthcare professionals
The work will also serve to increase professional awareness of the importance of frailty and its implications for clinical practice and clinical guidelines. Through our communications plan we aim to reach out to a range of professionals and expect the findings to influence practitioners' attitudes to frailty, which, depending on findings, might include changing approaches to screening for frailty and influencing methods in future clinical trials, for example, in relation to the way frailty is considered as a key variable.
Health policymakers and guideline developers
Our work will foster improved health and wellbeing of people living with frailty by influencing evidence generation and synthesis as well as clinical guideline development, thereby influencing healthcare policy. Highlighting the impact of frailty on clinical outcomes will better inform the response of clinicians, guideline developers, and policymakers to patients' needs, and help identify high risk patients at whom limited resources may be targeted. Considering how pharmacological and non-pharmacological interventions may be tailored to the context of frailty; variation in risks and benefits; and to what extent frailty is under-represented in existing evidence, will help inform treatment recommendations and clinical guidelines. This may allow more active and informed participation of patients in decisions relating to their care. Findings could inform further analyses exploring economic implications, and the cost-effectiveness of interventions, in the context of frailty.
Researchers and academics
The planned programme of research is novel and so the methodological approaches to evidence generation used in the context of frailty in the three exemplar NCDs may be adapted and refined for other disease contexts, extending the potential reach and relevance of the findings.
In summary, the proposed research will lead to improved management of frailty by generating evidence to inform clinical decision making; increasing awareness of the implications of frailty; and informing future development of interventions to optimise healthcare delivery for frail patients.
People |
ORCID iD |
Peter Hanlon (Principal Investigator / Fellow) |
Publications
Burton JK
(2021)
Impact of COVID-19 on care-home mortality and life expectancy in Scotland.
in Age and ageing
Crowther J
(2023)
Correlations between comorbidities in trials and the community: An individual-level participant data meta-analysis.
in Journal of multimorbidity and comorbidity
Dent E
(2023)
Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology.
in Ageing research reviews
Hanlon P
(2021)
Our response to rising frailty in younger people must address prevention burden.
in The lancet. Healthy longevity
Description | Collaboration with colleagues based in Mayo Clinic |
Organisation | Mayo Clinic |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | We are collaborating with experts in the Mayo clinic for the work assessing treatment burden in type 2 diabetes self-management. I am leading the work. |
Collaborator Contribution | Our collaborators are providing topic expertise as well as undertaking blinded assessment of interventions involving a theoretical framework with which they have specific expertise. |
Impact | Work is ongoing, currently working alongside these colleagues to carry out the planned systematic review and meta-analysis. |
Start Year | 2020 |
Description | EPI-FRAIL network |
Organisation | VU University Medical Center |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | I have been invited to join the EPI-FRAIL network of frailty epidemiology network. This is a relatively newly formed group working on a number of collaborative papers. |
Collaborator Contribution | Dr Emiel Hoogendijk leads the network and is coordinating 3 currently ongoing papers to which I am contributing. |
Impact | None yet |
Start Year | 2023 |
Description | Professor Andy Clegg - University of Leeds |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I am leading a systematic review project on the quantification of frailty in trials. Professor Clegg, an expert in frailty, has joined as a collaborator. |
Collaborator Contribution | I am leading the review. Professor Clegg will provide input into interpretation, results and dissemination. |
Impact | none yet |
Start Year | 2022 |
Description | Professor Kenneth Rockwood and group - Dalhousie University |
Organisation | Dalhousie University |
Country | Canada |
Sector | Academic/University |
PI Contribution | Professor Rockwood has contributed in an advisory role in planning the dissemination and future plans for the work carried out in this fellowship. This has led to an invitation to visit his group and to explore areas of future collaboration. |
Collaborator Contribution | Hosting visit to research group at Dalhousie University |
Impact | None yet |
Start Year | 2022 |
Description | 3-minute thesis event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | participation in the 3-minute thesis competition - involving presentation of the work in 3 minutes to an audience of staff and postgraduate students. |
Year(s) Of Engagement Activity | 2021 |
Description | Academic primary care trainee event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This was an event for General Practice trainees organised by NHS Education for Scotland and the Chief Scientist's Office, providing information about academic and research careers within primary care. I have an oral presentation about my fellowship work as well as workshops discussing research careers. There was discussion and dialogue about the project aims and methods. |
Year(s) Of Engagement Activity | 2019 |
Description | Explorathon researcher showcase |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | As part of Explorathon (part of the European Science Festival) I participated in the Researcher Showcase event. This involved creating a short public engagement video which was publicized on twitter as part of a wider event showcasing researchers in Scotland. The event was moved online as result of Covid-19 restrictions. |
Year(s) Of Engagement Activity | 2020 |
Description | Institute for Health and Wellbeing seminar series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | 15 minute presentation giving an overview of the work conducted in the fellowship for the various research groups within the University of Glasgow Institute for Health and Wellbeing |
Year(s) Of Engagement Activity | 2021 |
Description | International Scientific Advisory Board presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | As part of the Glasgow University Institute for Health and Wellbeing International Scientific Advisory Board visit I presented an outline of this MRC Fellowship award along with some early results. |
Year(s) Of Engagement Activity | 2020 |
Description | Panel meeting for related project |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Participating in an expert panel for a project related to frailty, I also was invited to provide an overview of the planned work and how it related to the wider challenges of frailty in primary care. |
Year(s) Of Engagement Activity | 2020 |
Description | Patient group workshop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Meeting with the NHS Research for Scotland Primary Care Patient and Public Involvement group. This allowed me to present plans for one aspect of this award (assessing the impact of frailty on self-management). I met with the group on two occasions. Once to gain their feedback on the outline of the project, and then on a second occasion to provide detailed feedback and dialogue around a coding frame to be used for analysis. |
Year(s) Of Engagement Activity | 2020 |
Description | Public engagement event: Pecha Kucha |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Online event of 'Pecha Kucha' talks as part of Explorathon (the Scottish part of the European Science festival). This involves a short presentation (20 slides, with 20 seconds per slide) presented a part of an event with 4 similar presentations. |
Year(s) Of Engagement Activity | 2020 |