Suppressing SARS-CoV-2 transmission in public spaces through surface engineering

Lead Research Organisation: University of St Andrews
Department Name: Physics and Astronomy

Abstract

The exploration of different ways in which the current Covid-19 pandemic can be kept controlled is crucial to enable reopening the society and ensure a flourishing economy. While a successful vaccine would be the ideal way to put a halt on the pandemic, a rapid deployment is not guaranteed, and may not happen for sometime. Short of a vaccine, measures that can prevent spreading the infection are an important alternative. Apart from airborne direct transmission, indirect transmission via surfaces, in particular in public spaces, can play an important role in spreading the disease. We propose the development and identification of routes for easy deployment of surface materials and coatings that can actively inhibit and retard the spread of the virus from an infected person to others via touch surfaces, by deactivating it. This would potentially be a game changer for "high-traffic" surfaces in public spaces. We will build on existing knowledge about the antiviral properties of copper, and seek to optimize them.

Technical Summary

Short of a vaccine that can be administered to large parts of the population, suppression of transmission of SARS-CoV-2 should be a priority to minimize the reproduction number and hence rate at which the disease spreads. A key transmission path for COVID-19 when lockdown restrictions are lifted is through contact with touch surfaces in public spaces that will be touched by many members of the public, for example door handles in public buildings and Schools or handles and holding rails in public transport. It is know that SARS-CoV-2 can survive for up to 48h on the often employed stainless steel surfaces, providing a direct pathway for transmission. Breaking this pathway is the key goal of this proposal, through identification of surface modifications that can more rapidly inactivate SARS-CoV-2 and thereby effectively suppress the transmission.

Publications

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Adamson CS (2021) Antiviral drug discovery: preparing for the next pandemic. in Chemical Society reviews

 
Description Our research has resulted in a list of materials and their antiviral properties with respect to the SARS-CoV2 virus, as well as provided insights into the deactivation mechanism of antiviral surfaces. From a survey of elemental metals, we have confirmed that copper has also for SARS-CoV2 superior deactivation properties. On a copper sample, the number of SARS-CoV2 viruses is reduced by 50% within 30min, whereas for most other metals, the deactivation is negligible in comparison. A study of a number of oxides reveals that Cu2O has significantly better deactivation properties compared to copper itself, showing a pathway to better antiviral surfaces.
Our study has further shown that deactivation at surfaces is dependent on the buffer medium, with significant differences in the deactivation properties for different buffer media. This result points to the importance of using physiological buffer media for tests of antiviral surfaces.
We have investigated the influence of the texture of a surface on its antiviral properties, suggesting that nano-structuring surfaces on length scales comparable with the size of the virus result in a significant reduction in the number of viable viruses the are retained in the buffer medium following exposure to the surface. This suggests a new way to optimise the antiviral properties of surfaces.
We are currently preparing these results for publication.
Exploitation Route We have been in discussions with a number of companies that were interested in our results and the potential implications for public health. It is too early to say how our results might affect the use of certain materials for surfaces in public spaces.
We plan to apply for further funding to optimise the antiviral properties of our surfaces, combining the copper oxide surface with nano structuring, which should boost the antiviral properties.
Sectors Healthcare,Other

 
Title Phase diagram of CeSb2 from magnetostriction and magnetization measurements: Evidence for ferrimagnetic and antiferromagnetic states (dataset) 
Description  
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
URL https://risweb.st-andrews.ac.uk/portal/en/datasets/phase-diagram-of-cesb2-from-magnetostriction-and-...
 
Description Science Discovery Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We offer the general public hands-on experience with cryogenics and superconductors, showing high temperature superconductivity by demonstrating magnetic levitation.
Year(s) Of Engagement Activity 2018,2021,2022
URL https://events.st-andrews.ac.uk/events/science-discovery-day/