A simplified and robust gut model for assessing health risks from soil pollutants
Lead Research Organisation:
University of Reading
Department Name: Geography and Environmental Sciences
Abstract
Dr Chris Collins has developed an improved laboratory-based model of the gastrointestinal tract for determining the bioaccessibility of soil pollutants when ingested. Recent research has shown that models used to assess the risk to human health from soil pollutants need to take account of bioaccessibility in the gut environment in order not to be unduly conservative and we have developed an appropriate tool to measure this. Although successful for research purposes, the laboratory model is too complex for the routine assessment of soil samples. It is thought that what the industry is really looking for is a simpler robust test kit for the routine testing of field samples. The immediate customers of the technology will be either laboratories undertaking soil assessment services or a supplier of soil and microbial analysis and diagnostic equipment, depending on what route to market is chosen. The funding will enable preliminary market research report to be completed by external consultants and investigate the freedom to operate. In a limited parallel project funded from the University of Reading Higher Education Iinnovation Proof of Concept and Feasibility Fund, the technical proof of concept for a the simplified gut model is being evaluated up to a point where finished protocol can be tested by an independent laboratory. Results from the project will enable us to develop an appropriate strategy for commercialising the technology.
People |
ORCID iD |
Christopher Collins (Principal Investigator) |
Publications
Abdallah MA
(2012)
In vitro assessment of the bioaccessibility of brominated flame retardants in indoor dust using a colon extended model of the human gastrointestinal tract.
in Journal of environmental monitoring : JEM
Tilston EL
(2011)
Colon extended physiologically based extraction test (CE-PBET) increases bioaccessibility of soil-bound PAH.
in Environmental science & technology
Description | This enabled us to look at the potential impact of our newly developed CEPBET model for bioaccessibility. We recruited an environmental consultant to advise us and talk to the user community to determine appropriate mechanisms for marketing the test. |
Exploitation Route | The test has been used by environmental consultants and local authorities within the UK to determine the risks from contaminated land. We have used the test in 3 research projects. Two funded by the EU to look at the release of flame retardants from dusts in the gut and one funded by the EPSRC to support sustainable land development. |
Sectors | Chemicals,Construction |
Description | The findings have been used by consultants and local authorities to assess the risks from contaminated land. |
First Year Of Impact | 2009 |
Sector | Communities and Social Services/Policy,Construction,Education,Environment |
Impact Types | Economic,Policy & public services |
Description | Marie Curie ITN |
Amount | € 250,000 (EUR) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2013 |
End | 01/2017 |
Description | Marie Curie ITN |
Amount | € 250,000 (EUR) |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 03/2011 |
End | 03/2014 |
Description | A team |
Organisation | University of Birmingham |
Department | Ironbridge International Institute for Cultural Heritage |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We were part of a Innovative Training Network investigating the exposure of humans to flame retardants (FRs) in the indoor environment. We were quantifying the bioaccessibility of FRs in house dust |
Collaborator Contribution | Other partners focused on other exposure pathways or quantified the sources. |
Impact | Katerina Kademoglou*, Fuchao Xu, Juan Antonio Padilla-Sanchez, Line Småstuen Haug, Adrian Covaci, Chris D. Collins (2016) Legacy and alternative flame retardants in Norwegian and UK indoor environment: Implications of human exposure via dust ingestion, Environment International, In press. doi: 10.1016/j.envint.2016.12.012 |
Start Year | 2014 |