A simplified and robust gut model for assessing health risks from soil pollutants

Lead Research Organisation: University of Reading
Department Name: Geography and Environmental Sciences

Abstract

Dr Chris Collins has developed an improved laboratory-based model of the gastrointestinal tract for determining the bioaccessibility of soil pollutants when ingested. Recent research has shown that models used to assess the risk to human health from soil pollutants need to take account of bioaccessibility in the gut environment in order not to be unduly conservative and we have developed an appropriate tool to measure this. Although successful for research purposes, the laboratory model is too complex for the routine assessment of soil samples. It is thought that what the industry is really looking for is a simpler robust test kit for the routine testing of field samples. The immediate customers of the technology will be either laboratories undertaking soil assessment services or a supplier of soil and microbial analysis and diagnostic equipment, depending on what route to market is chosen. The funding will enable preliminary market research report to be completed by external consultants and investigate the freedom to operate. In a limited parallel project funded from the University of Reading Higher Education Iinnovation Proof of Concept and Feasibility Fund, the technical proof of concept for a the simplified gut model is being evaluated up to a point where finished protocol can be tested by an independent laboratory. Results from the project will enable us to develop an appropriate strategy for commercialising the technology.

Publications

10 25 50
 
Description This enabled us to look at the potential impact of our newly developed CEPBET model for bioaccessibility. We recruited an environmental consultant to advise us and talk to the user community to determine appropriate mechanisms for marketing the test.
Exploitation Route The test has been used by environmental consultants and local authorities within the UK to determine the risks from contaminated land.
We have used the test in 3 research projects. Two funded by the EU to look at the release of flame retardants from dusts in the gut and one funded by the EPSRC to support sustainable land development.
Sectors Chemicals,Construction

 
Description The findings have been used by consultants and local authorities to assess the risks from contaminated land.
First Year Of Impact 2009
Sector Communities and Social Services/Policy,Construction,Education,Environment
Impact Types Economic,Policy & public services

 
Description Marie Curie ITN
Amount € 250,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2013 
End 01/2017
 
Description Marie Curie ITN
Amount € 250,000 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 03/2011 
End 03/2014
 
Description A team 
Organisation University of Birmingham
Department Ironbridge International Institute for Cultural Heritage
Country United Kingdom 
Sector Academic/University 
PI Contribution We were part of a Innovative Training Network investigating the exposure of humans to flame retardants (FRs) in the indoor environment. We were quantifying the bioaccessibility of FRs in house dust
Collaborator Contribution Other partners focused on other exposure pathways or quantified the sources.
Impact Katerina Kademoglou*, Fuchao Xu, Juan Antonio Padilla-Sanchez, Line Småstuen Haug, Adrian Covaci, Chris D. Collins (2016) Legacy and alternative flame retardants in Norwegian and UK indoor environment: Implications of human exposure via dust ingestion, Environment International, In press. doi: 10.1016/j.envint.2016.12.012
Start Year 2014