A novel analytical assay for the spectrophotometric determination of phosphate in natural waters

Lead Research Organisation: NATIONAL OCEANOGRAPHY CENTRE
Department Name: Science and Technology

Abstract

The objective of this Pathfinder application is to secure funding of £3,990 plus VAT to file a patent at the UK patent office for a novel assay for phosphate (bioavailable form of phosphorous) analysis in natural waters that demonstrates significantly better performance both in laboratory analysis and within in situ autonomous wet chemical sensors. The patent will aim to protect the assay as a product and also the recipe to the assay/product.
We will need to instruct the patent attorney, Nick Braddon of Barker Brettell, who has quoted £3,200 plus VAT to file the patent at the UK patent office. The work will require us (i.e. Charlie Morgan of the NOC Enterprise Team, Dr. Geraldine Turner and Dr. Socratis Loucaides) providing instructions to Nick Braddon which typically involves a face-to-face meeting (c. 3 hours), review and amending Nick's draft (c. 3 hours) and finalising the draft (c.1 hour) and then Nick filing the patent at the UK patent office.
Once filed in the UK, we intend to commission a new independent market study with additional Pathfinder funds to research the markets for its application within (i) environmental/water quality sensor manufacturers for in situ applications (e.g. Seabird Scientific, Xylem, TE Laboratories) and (ii) suppliers of assays (chemical solutions) for laboratory use worldwide (e.g. Scaler, Seal, Hach and Agilent).
The patent filing and subsequent market research will provide NERC and NOC with timely market information to evaluate the commercial opportunities of the new assay. It will help us to ensure we secure the best possible license deals across the different markets. As the technology is now reaching mature levels, the research will inform our decision making around how we license the technologies by identifying the leading companies in each market and it could open new doors for licensing opportunities within different market sectors (e.g. the chemicals industry) and inform our future technology development plans to meet anticipated market needs.

Planned Impact

The PVP assay, we believe, will deliver the benefits as outlined above meaning our phosphate lab on chip sensor will become even more 'fit for purpose' increasing its adoption. In terms of the societal impact, the sensor will help scientists collect more and higher quality phosphate in situ data over longer periods via a variety of platforms including fixed buoys, gliders and autonomous underwater vehicles and this will lead to a greater understanding of the biogeochemical processes which play a crucial role in our climate change studies. We also anticipate other end-users (as outlined above) will benefit from assay's capabilities although we want to test this with an independent market research study. The economic impact should be seen through the prism of adding value to the relevant markets and generating increased revenue for the UK Treasury via corporation tax of our UK licensee partners and/or inward investment by our international partners. By improving the product port-folio of these companies, it may also contribute to the creation of jobs within these companies, and/or to the potential creation of a manufacturing spin-out company and to the continued investment into NOC's world leading sensor development programme. Royalty income would also be generated for NERC/NOC which can be re-invested into scientific research, technology development and/or the protection of new technologies.

Publications

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Description This was a pathfinder application to cover expenses for filing a patent for a new spectrophotometric analytical assay for the detection of phosphate in natural waters.
The patent has been written and filed by Barker Brettell LLP for our behalf. Application numbers: (NCB82429P.WOA): International (PCT) patent application no. PCT/GB2016/053533
Exploitation Route The patent on this new analytical assay will bring income to NERC and UK through licensing fees. The analytical assay will improve analytical performance in monitoring pollution and understanding natural biogeochemical cycles. It will be of value to industry, regulatory agencies and the research sector.
Sectors Agriculture, Food and Drink,Chemicals,Environment,Manufacturing, including Industrial Biotechology,Other

 
Description The IP protection and market research funded by this grant has led to commercialisation of the IP through a license agreement with a commercial company (Clearwater Sensors). This company will implement this analytical technique to their autonomous sensors for chemical observations in natural waters.
First Year Of Impact 2020
Sector Agriculture, Food and Drink,Environment
Impact Types Economic

 
Title MOLYBDENUM BLUE ASSAY FOR MEASUREMENT OF CHEMICAL SPECIES 
Description A process for measuring a concentration of a chemical species in an aqueous sample employing polyvinylpyrrolidone. The process comprises : providing an aqueous sample containing the chemical species; mixing the aqueous sample with a first reagent that comprises a solution of a molybdenum VI salt to provide a first solution; mixing the first solution with a second reagent that comprises a reducing agent to form a second solution; and measuring a property of the second solution to determine the concentration of the chemical species. Polyvinylpyrrolidone is added to the aqueous sample, the first reagent, the first solution or the second solution. The intensity of light absorbed or transmitted by the second solution may be used to determine the concentration of the chemical species. 
IP Reference WO2018087507 
Protection Patent application published
Year Protection Granted 2018
Licensed No
Impact The patent application adds value to the devices developed at NOC which use this technology. These devices are currently in the process of being commercialised.