Revealing the hidden coding potential and dynamics of the mammalian transcriptome
Lead Research Organisation:
Babraham Institute
Department Name: Immunology
Abstract
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Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M017141/1 | 30/09/2015 | 29/09/2019 | |||
| 1642216 | Studentship | BB/M017141/1 | 30/09/2015 | 29/09/2019 |
| Description | Identification of the coding elements in the genome is a fundamental step in understanding the building blocks of living system. Micropeptides of 100 amino acid residues and fewer have emerged as important regulators of development and physiology. Small open read frames or smORFs of 100 codons and fewer are potentially translatable into micropeptides. We have built a computational pipeline to identify translated smORFs in the lymphocytes using sequencing data. Thousands of smORFs were predicted and are being analysed. We have so far predicted 5574 actively translated smORFs in the lymphocytes. A subset of them were predicted to have signal peptides, thus they have the potential to be secreted. |
| Exploitation Route | 1. Our computational pipeline will be open source to the bioinformatics community to analysis sequencing data. 2. The micropeptides predicted potentially have therapeutic applications. |
| Sectors | Digital/Communication/Information Technologies (including Software) Pharmaceuticals and Medical Biotechnology |