Kinome reprogramming in response to activating KRAS mutations and Ras pathway therapeutics
Lead Research Organisation:
University of Liverpool
Department Name: Institute of Translational Medicine
Abstract
Kinome reprogramming in response to activating KRAS mutations and Ras pathway therapeutics
People |
ORCID iD |
Publications
Wilson LJ
(2018)
New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.
in Cancer research
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/N504208/1 | 30/09/2015 | 29/09/2019 | |||
| 1651560 | Studentship | BB/N504208/1 | 30/09/2015 | 29/09/2019 |
| Description | We have established a kinome profile method and applied it to studying cell signalling downstream of Ras proteins. This allows us to understand how cell communication systems are wired under normal conditions and how they might be rewired when key communication systems are mutated. The work is important because it allows us to compare the difference between very closely related protein family members where subtle changes in outputs can have significant differences in normal cell behaviour. |
| Exploitation Route | The method can be used by anybody with an interest in cell communication systems. It allows broad measurement of the activation/expression of a key set of cell signalling proteins. |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |