Chemical Tools to Probe the Role of Bromodomains in the Parasite Trypanosoma cruzi
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
The acetylation of lysine on histones tails is a key post-translational modification (PTM), which affects gene expression in a wide range of species. Bromodomains are readers for such PTMs, and have been shown to be ligandable targets that affect human diseases including cancer, inflammation, and diabetes. The function of bromodomains in non-human organisms is poorly understood, however, given the fundamental role played by bromodomains in regulating transcription in humans, we hypothesise that bromodomain-containing proteins will play equally important roles in other organisms. The aim of the project is to design, synthesize and optimize small molecules to probe the function of bromodomain-containing proteins from the parasite Trypanosoma cruzi.
Organisations
- University of Oxford (Lead Research Organisation)
- UNIVERSITY OF OXFORD (Collaboration)
- University of Melbourne (Collaboration)
- National University of Rosario (Collaboration)
- University of Georgia (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Genome Research Ltd (Collaboration)
- GlaxoSmithKline (United Kingdom) (Student Project Partner)
People |
ORCID iD |
| Stuart Conway (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M015157/1 | 01/10/2015 | 30/09/2019 | |||
| 1658843 | Studentship | BB/M015157/1 | 01/10/2015 | 30/09/2019 |
| Description | Parasite network |
| Organisation | Genome Research Ltd |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | National University of Rosario |
| Country | Argentina |
| Sector | Academic/University |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | University of Georgia |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | University of Melbourne |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | University of Oxford |
| Department | Structural Genomics Consortium (SGC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |
| Description | Parasite network |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Work towards validating Bromodomains in Trypanosoma cruzi parasite as viable epigenetic targets for anti-parasitic therapies. |
| Collaborator Contribution | Work towards validating Bromodomains in parasites as viable epigenetic targets for anti-parasitic and neglected disease therapies. |
| Impact | Multi-disciplinary collaboration involving organic chemistry as well as chemical, molecular, and structural biology. |
| Start Year | 2017 |