modulation of stem cells and bacteria at titanium surfaces via nanotopography and peptides
Lead Research Organisation:
University of Bristol
Department Name: Oral and Dental Science
Abstract
modulation of stem cells and bacteria at titanium surfaces via nanotopography and peptides
People |
ORCID iD |
| Bo Su (Primary Supervisor) | |
| Marcus Eales (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M017214/1 | 01/10/2015 | 30/09/2019 | |||
| 1723473 | Studentship | BB/M017214/1 | 01/10/2015 | 30/09/2019 | Marcus Eales |
| Description | Original work into understanding how the surface's physical and chemical characteristics effects how an antimicrobial peptide is released and its subsequent antimicrobial effect on numerous bacterial species. |
| Exploitation Route | Optimising the surface's physical and chemical characteristics to enhance release. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | In vitro and in vivo studies of 3D orthopaedic implants with cell-instructive nanotopographies |
| Amount | £699,713 (GBP) |
| Funding ID | MR/S010343/1 |
| Organisation | University of Bristol |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2022 |
| Description | Functionalised Titanium Dioxide Nanowires for Applications in Implantable Medical Devices: A Synergistic Approach |
| Organisation | University of Bristol Dental Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Through the optimisation of growth of nanotopography carried out in my project a colleague was taught how to grow the nanotopography. I also helped and had intellectual input in the optimisation of the salinization and viability assays of live/dead staining and bactiter-glo. |
| Collaborator Contribution | Colleagues had intellectual input into the growth and optimisation of the nanotopography, salinization and attachment of enzymes onto the surface of the titanium and the viability assays of live/dead and bactiter-glo. |
| Impact | Submitted paper draft to Langmuir on 6th February 2018 with the title Functionalised Titanium Dioxide Nanowires for Applications in Implantable Medical Devices: A Synergistic Approach. |
| Start Year | 2016 |
| Description | Modulation of stem cell interaction with nanotopography surface |
| Organisation | University of Glasgow |
| Department | Institute of Molecular Cell and Systems Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Taught student how to form nanotopography on surface of titanium and also how to quantify the viability of bacteria wen interacting with the surface with live/dead assay and bactiter-glo. |
| Collaborator Contribution | Lead researcher investigates how stems cells and bacteria interact with surfaces containing nanotopography and other functionalised compounds. |
| Impact | None yet. |
| Start Year | 2016 |
| Description | BigBangBristol 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | 100s of early secondary school students attended science outreach event 'BigBangBristol 2017'. Had an interactive exhibit where we described our research, the importance of it and how it relates to them. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Research without Borders |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | School children, the general public and university students attended a outreach event called Research without Borders organised and supported by the University of Bristol. Showcased research group research to a broad range of expertise and interests in an interactive and personal manner. |
| Year(s) Of Engagement Activity | 2018 |
| Description | We the Curious |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Showcased research group research with primary school and lower secondary school students with an interactive and entertaining exhibit. |
| Year(s) Of Engagement Activity | 2018 |