Development of a Novel Haemo-Rheological Test and Biomarker and its Evaluation in Patients with Stroke
Lead Research Organisation:
Swansea University
Department Name: Institute of Life Science Medical School
Abstract
The aim of the research is to develop a new rheological test that accurately detects the onset of clot lysis (de-Gel Point) and has the ability to assess and monitor patient response to the therapeutic break down of blood clots. We propose to show that the de-Gel Point is able to detect thrombolytic therapy in a pilot study involving a small cohort of stroke patients. Furthermore, we aim to determine whether a correlation between rheological parameters collected during analysis of the Gel Point and de-Gel Point can be related to clinical outcomes in patients diagnosed with acute ischemic stroke. The research area is Clinical Technologies.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509553/1 | 01/10/2016 | 30/06/2022 | |||
| 1799900 | Studentship | EP/N509553/1 | 01/07/2016 | 31/12/2019 | Bethan Morgan |
| Title | Research as Art: Seeing Stroke |
| Description | An image was created combining a photograph of a blood sample with one of the human eye for entry into the competition research as art. |
| Type Of Art | Image |
| Year Produced | 2018 |
| Impact | This was displayed as part of the research as art competition and event. |
| Description | Protocol for detection of clot lysis using FTMS has been optimised and validated. Assessment has shown potential applications for both stroke patient care and for testing novel therapeutics during development. |
| Exploitation Route | The optimised test could be taken forward for assessment in clinical cases. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Title | FTMS Procedure for Testing Platelet Free Plasma |
| Description | A procedure using Fourier transform mechanical spectroscopy was optimised to take rheological gel point measurements of human blood plasma. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This technique will be used in future gel point detection within the project and will presented as a poster at a rheology conference later in 2019. |
| Description | World Thrombosis Day Guinness World Record Attempt |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | A Guinness world record attempt to achieve the most hits of a person by water balloons was undertaken at Swansea University in order to raise awareness of world thrombosis day. |
| Year(s) Of Engagement Activity | 2017 |