DNA repair and mutagenesis at replication forks: analysis of HelQ and Rrm3 helicases
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Biosciences
Abstract
The project focuses on HelQ, a human DNA repair enzyme. Malfunctions in HelQ are associated with the onset of some cancers, by mechanisms that are unclear but seem to relate to the ability of HelQ to interact with Rad51 and Rad51 paralogue enzymes. The rotation will spend a few weeks doing biochemical analysis of helicase enzymes by (a) the effects of site-directed mutagenesis on ATPase, DNA binding and helicase activity and/or (b) analysis of helicase protein-protein interactions with Rad51 and its paralogues.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M008770/1 | 01/10/2015 | 31/10/2024 | |||
| 1803154 | Studentship | BB/M008770/1 | 01/10/2016 | 25/11/2020 |
| Description | I have used my research and findings at public engagement events with the public. While the exact work and research may not impact society yet in these early stages. I believe that the use of this work to communicate to the public has been of great importance in my activities. |
| First Year Of Impact | 2019 |
| Sector | Education |
| Description | The Festival of Curiosity Nottingham |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | I hosted an activity at the Festival of Curiosity in February 2019 and again in 2020 on different areas of my research field in DNA, damage and repair. We set up activities for the general public focusing mainly on younger people. Our aim was to start a conversation about how DNA works, how it can become damaged and then the systems involved in its repair. |
| Year(s) Of Engagement Activity | 2019,2020 |
| URL | https://www.nottsfosac.co.uk |