Evolution of Homeobox Genes and Mammalian Embryo Development - WCUB, ENWW
Lead Research Organisation:
UNIVERSITY OF OXFORD
Department Name: Interdisciplinary Bioscience DTP
Abstract
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Organisations
Publications
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011224/1 | 30/09/2015 | 31/03/2024 | |||
| 1810161 | Studentship | BB/M011224/1 | 30/09/2015 | 31/12/2019 |
| Description | We are interested in the evolution and function of the earliest stages of mammalian development. We have discovered that, although some genes show marked differences in gene sequence and number between mouse and human genomes, there is some overlap in their function. Additionally we have analysed the evolutionary history of these genes and identified subfunctionalisation in the placental mammal lineage, followed by what we think is specialisation of their function |
| Exploitation Route | Our results inform about the earliest stages of mouse development and draw comparisons between mouse and human embryogenesis. We show that gene family evolution can be very dynamic and supply an instance of where intense gene content evolution may contribute to phenotypic evolution. |
| Sectors | Other |
| URL | https://evodevojournal.biomedcentral.com/articles/10.1186/s13227-018-0091-4 |