📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.

Lead Research Organisation: University of Warwick
Department Name: Chemistry

Abstract

This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.

This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.

People

ORCID iD
Tomos Morgan (Student)

Publications

10 25 50
publication icon
Banerjee S (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. in Chemical science

publication icon
Chiu CKC (2020) Metallocomplex-Peptide Interactions Studied by Ultrahigh Resolution Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

publication icon
Floris F (2018) Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin. in Journal of the American Society for Mass Spectrometry

publication icon
Lam YPY (2020) Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

publication icon
Lam YPY (2018) Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? in Chemical communications (Cambridge, England)

publication icon
Lam YPY (2020) Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation? in Chemical communications (Cambridge, England)

publication icon
Lermyte F (2019) MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics. in Analytical chemistry

publication icon
Lermyte F (2019) Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

publication icon
Lermyte F (2019) Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches. in Journal of the American Society for Mass Spectrometry

publication icon
Lermyte F (2019) Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. in Cells

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510695/1 30/09/2016 31/12/2021
1837376 Studentship EP/P510695/1 30/09/2016 29/03/2020 Tomos Morgan