Using mathematical modelling of the Langerhans cell tolerogenic gene regulatory network to identify key molecular regulators of the tolerogenic progra
Lead Research Organisation:
University of Southampton
Department Name: Clinical and Experimental Sciences
Abstract
Skills Priority Alignment: Quantitative Biology
Hypothesis
LC tolerogenic ability is regulated by a unique gene regulatory network (GRN), which induces a distinct gene expression profile associated with the tolerogenic LC programme.
Aims
1) Investigate cell-cell variation within LC populations.
2) Dissect a unique gene expression profile associated with tolerance in LCs and identify the TFs essential for regulating LC tolerogenic function.
3) Create a mathematical model of the LC tolerogenic GRN for quantitative in silico simulations that correctly predict the expression of tolerogenic output genes
4) Identify the key molecular switches regulating tolerogenic responses and validate in vitro.
Hypothesis
LC tolerogenic ability is regulated by a unique gene regulatory network (GRN), which induces a distinct gene expression profile associated with the tolerogenic LC programme.
Aims
1) Investigate cell-cell variation within LC populations.
2) Dissect a unique gene expression profile associated with tolerance in LCs and identify the TFs essential for regulating LC tolerogenic function.
3) Create a mathematical model of the LC tolerogenic GRN for quantitative in silico simulations that correctly predict the expression of tolerogenic output genes
4) Identify the key molecular switches regulating tolerogenic responses and validate in vitro.
Organisations
People |
ORCID iD |
| Marta Ewa Polak (Primary Supervisor) | |
| James Davies (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N014308/1 | 01/10/2016 | 30/09/2025 | |||
| 1856566 | Studentship | MR/N014308/1 | 01/10/2016 | 30/09/2020 | James Davies |
| Description | 16th International Langerhans cell workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at the conference followed by questions. Networking with other researchers in the filed. |
| Year(s) Of Engagement Activity | 2019 |
| Description | British Society of Investigative Dermatology Annual Meeting 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Annual meeting for the BSID, attended by around 200 people. Involved 15 minute presentation and questions to the whole audience. |
| Year(s) Of Engagement Activity | 2018 |
| Description | University of Southampton Medical research conference 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 15 minute presentation followed by questions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Wessex Immunology Group Annual Meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation. I won the award for best poster presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Wessex Immunology Group Annual meeting 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | 15 minute presentation at the Wessex Immunology Group Annual Meeting. I won the award for best oral presentation. |
| Year(s) Of Engagement Activity | 2018 |