Brain inspired machine learning methods for analysis of neural data

Lead Research Organisation: Imperial College London
Department Name: Electrical and Electronic Engineering

Abstract

Recent developments in neuroscience have produced electrical probes capable of recording the activity of hundreds or even thousands of neurons (brain cells) simultaneously. This opens the possibility for neuroscientists to discover new principles of brain function that would not have been possible with previous technology that could only record from a single neuron or a handful of neurons simultaneously. Unfortunately, despite the technology to record this data being very advanced, our ability to analyse the data has not kept pace. A number of heavily mathematical methods have been proposed. These have some promise, but share a common problem: they discover patterns in the data but they do not tell you if or how the brain itself might make use of those patterns.
The aim of this research is to use brain-inspired methods to analyse the data, so that patterns that are discovered in the data would also be discoverable by the brain itself. This will lead to hypotheses that are much more closely linked to how the brain functions than existing methods.
This research proposes hybrid methods that combine neural modelling with machine learning (a collection of techniques that has recently produced incredible results in solving tasks that were previously thought to require human intelligence). By incorporating neural models into the analysis, we ensure that the results are themselves something that the brain could potentially discover itself. By incorporating machine learning, we use the best currently known, state of the art methods for detecting patterns.
This research has the potential to enable significant future discoveries about how the brain works and how it outperforms computers at many important tasks. It falls under the remit of the following EPSRC research areas: biological informatics; artificial intelligence technologies.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509486/1 01/10/2016 31/03/2022
1895488 Studentship EP/N509486/1 01/10/2016 31/03/2020 Pamela Hathway
 
Description I developed a new data analysis technique for data that was recorded from brains of mice vis electrodes. The tool, neural topic modelling, can make use of large data sets and lets researchers explore their own data in a new way. The data is used more efficiently, so less datasets are needed for the same conclusions, and different aspects of the expriment can be looked at at the same time, decreasing the number of analyses that have to be run at the start of analysing data. Neural topic modelling can point researchers towars new and exciting research directions. The tool will be made publically available (open source) to the research community.
Exploitation Route My data analysis tool can be used by the general research community and will be continued to be used by member of my research group.
Sectors Pharmaceuticals and Medical Biotechnology

 
Title Neural Topic Modelling 
Description Neural Topic modelling is an unsupervised data analysis method for large-scale electrophysiological data sets. It increases the information that can be gained from a data set and therefore decreases the need for the creation of more datasets. 
Type Of Material Data analysis technique 
Year Produced 2018 
Provided To Others? No  
Impact I used it for my publications and am working on making it available for the general research community to use (still under development) 
 
Description School Visit at North London Collegiate School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Held a talk about my research at the "Engineering and Technology Symposium" of the North London Collegiate School. About 70 students of the school and some surrounding schools attended.
Year(s) Of Engagement Activity 2020
 
Description Work experience student coming to work with me 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact After holding a talk at her school about my research, one of the girls asked whether she could do a work experience with me. So she will be working with me for two weeks in the summer.
Year(s) Of Engagement Activity 2020