Analysis of how specific RNA motifs in HIV-1 and lentiviral vector genomes control infectious virus production
Lead Research Organisation:
King's College London
Department Name: Immunology Infection and Inflam Diseases
Abstract
We hypothesise that an innate immune pathway recognises HIV-I RNA containing CpG dinucleotides and inhibits viral replication. This project will analyse how CpG dinucleotides in the HIV-I genome and lentivirat vector genomes are sensed by the innate immune system and inhibit viral replication.
Organisations
People |
ORCID iD |
| Mattia Ficarelli (Student) |
Publications
Ficarelli M
(2020)
CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms.
in Journal of virology
Ficarelli M
(2021)
Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System.
in Annual review of virology
Kmiec D
(2021)
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies.
in PLoS pathogens
Lista MJ
(2023)
A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods.
in Journal of virology
Lista MJ
(2021)
Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation.
in PloS one
Sertkaya H
(2021)
Minimal impact of ZAP on lentiviral vector production and transduction efficiency.
in Molecular therapy. Methods & clinical development
Sertkaya H
(2021)
HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency.
in Scientific reports
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/R50225X/1 | 30/09/2017 | 29/04/2024 | |||
| 1939180 | Studentship | MR/R50225X/1 | 30/09/2017 | 29/06/2021 | Mattia Ficarelli |