Using SABRE to hyperpolarisation agents for magnetic resonance detection
Lead Research Organisation:
University of York
Department Name: Chemistry
Abstract
The technique of "spin hyperpolarised" Magnetic Resonance (MR) has the potential to provide a safe and uniquely versatile high-sensitivity tool for analytical science, medical research, drug discovery and clinical diagnostics. We will employ "Signal Amplification by Reversible Exchange" ("SABRE") and the more recently developed SABRE-RELAY method to achieve the spin hyperpolarisation of a range of 1H, 31P, 19F, 13C and 15N nuclei in an array of drugs, metabolites and biomarkers in seconds. We will then target their NMR and MRI detection, at high and low field, whilst developing an array of analytical methods to achieve their rapid characterisation.
Organisations
People |
ORCID iD |
| S Duckett (Primary Supervisor) | |
| Benjamin Tickner (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509802/1 | 01/10/2016 | 31/03/2022 | |||
| 1941550 | Studentship | EP/N509802/1 | 01/10/2017 | 30/09/2020 | Benjamin Tickner |
| Description | We have been able to increase the magnetic resonance signals for a range of different molecules which has been used for a range of applications including biomolecular imaging, detecting reaction intermediates and monitoring chemical change. |
| Exploitation Route | We have developed new ways to increase the magnetic resonance signals for a new classes of molecules. This technology can be used to do the same for other molecules and new applications can then be applied |
| Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |
| URL | https://www.york.ac.uk/chym/our-staff/research/tickner-ben/#profile-content |