1) Functional and mechanistic analysis of novel human cytomegalovirus restriction factors.
Lead Research Organisation:
University of Cambridge
Department Name: CIMR Medicine
Abstract
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013433/1 | 01/10/2016 | 30/04/2026 | |||
| 1943125 | Studentship | MR/N013433/1 | 01/10/2017 | 31/12/2021 | Alice Fletcher-Etherington |
| Title | Mass spectrometry data for 48 h HCMV degradation screen in human fibroblasts |
| Description | Raw mass spectrometry data for a 48 h HCMV degradation screen, performed as explained in the paper 'Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor' (DOI 10.1073/pnas.2001887117). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Discovery of a novel mechanism of viral inhibition of necroptotic cell death. |
| URL | http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD017279 |
| Description | Collaboration with Dr Richard Stanton at Cardiff University |
| Organisation | Cardiff University |
| Department | School of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We perform proteomic experiments on cells infected with HCMV recombinant viruses. |
| Collaborator Contribution | The lab of Dr Richard Stanton generates HCMV recombinant viruses for us to use in our work, including but not exclusively for work related to this award. |
| Impact | This collaboration resulted in the paper related to this award, 'Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor'. |
| Start Year | 2017 |
| Description | Collaboration with Professor Andrew Davison at the University of Glasgow |
| Organisation | University of Glasgow |
| Department | Institute of Infection, Immunity and Inflammation |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our research team does proteomic experiments cells infected with HCMV. |
| Collaborator Contribution | The lab of Professor Davison sequences the viruses that we use in our work, including but not exclusively for work related to this award. |
| Impact | This collaboration resulted in the paper related to this award, 'Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor'. |
| Start Year | 2017 |
| Description | Cambridge Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Cambridge Big Biology day is a science fair aimed at primary and secondary school children at which University departments and institutes related to biology provide interactive exhibits. I helped at our institutes stall, which involved having conversations with children and adults about my research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Cambridge Science Festival is a University-wide public outreach event. My institute takes part by hosting a stall at the science fair, where we have the opportunity to teach children about 'Cells and Disease' and talk to adults about our research. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.festival.cam.ac.uk/ |
| Description | Cambridge University Postgraduate Outreach Scheme |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Delivered 1-2 hour interactive taster lectures to secondary school and college students on University Open Days, consisting of a lecture on 'Viruses and Disease' and a Q+A about undergraduate and postgraduate study and my specific area of research. Received very good feedback from students and teachers, with some students contacting me afterwards with further questions. |
| Year(s) Of Engagement Activity | 2017,2018 |