Epitranscriptomic mechanisms of endocrine signalling
Lead Research Organisation:
University of Nottingham
Department Name: School of Veterinary Medicine and Sci
Abstract
Epitranscriptomics, dynamic covalent modifications of RNA, has recently emerged as an important determinant of gene expression, splicing and translation. The most abundant RNA modification, m6A, is catalysed by the METTL3 complex, whereas two enzymes, FTO and ALKBH5, are believed to be responsible for RNA demethylation. The focus of this project is to identify diverse functions of the epitranscriptome in endocrine signalling.
Organisations
People |
ORCID iD |
Publications
Haigh DB
(2022)
The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.
in Cancers
Harris AE
(2022)
Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.
in Frontiers in endocrinology
Lothion-Roy J
(2022)
Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.
in Frontiers in genetics
Woodcock CL
(2024)
The role of the ALKBH5 RNA demethylase in invasive breast cancer.
in Discover oncology
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M008770/1 | 30/09/2015 | 31/03/2024 | |||
| 1945091 | Studentship | BB/M008770/1 | 30/09/2017 | 25/11/2021 | |
| NE/W503162/1 | 13/04/2021 | 12/04/2022 | |||
| 1945091 | Studentship | NE/W503162/1 | 30/09/2017 | 25/11/2021 |
| Description | Our group has participated in Prostate Cancer UK's March for Men even in Nottingham. This involved interacting with members of the public,, including patients, and speaking to them about the work that PCUK do. |
| First Year Of Impact | 2018 |
| Sector | Healthcare |
| Impact Types | Societal |