The role of intermediary metabolism on skin ageing and interplay between inflammation and senescence
Lead Research Organisation:
Queen Mary University of London
Department Name: Blizard Institute of Cell and Molecular
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Michael Philpott (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/R505420/1 | 30/09/2017 | 31/12/2021 | |||
| 1962581 | Studentship | BB/R505420/1 | 30/09/2017 | 29/09/2021 |
| Description | This project aims to study biological mechanisms of the process of ageing in human skin. To understand the process better the project has allowed to develop two physiologically relevant study models of skin ageing. These models induce cell damage, cell cycle arrest and proliferation loss (which is termed as 'senescence') via: 1) treating human cells with ultraviolet radiation, or 2) through continous cell culture until cell proliferation capacity is exhausted. Therefore, this project has allowed to: 1) implement new culture models to study senescence, 2) study the differences and biological relevance of these models 3) collaborate with various academic leads and bring their expertise and views to the project 4) attract interest from industrial collaborator, providing experimental guidance as well as the financial support to equip the project 5) improved my research skills and knowledge in the field through providing additional training and attendance of specialist courses (e.g SysMIC, Cellular Bioenergetics Course on metabic fluxes) |
| Exploitation Route | Research methods and the knowledge obtained from the project will greatly benefit to the field of senescence, ageing and skin biology. More specifically, identification of specific genes, proteins and metabolites associated with ageing will enhance the development of therapeutics and novel active agents to promote human longevity and wellbeing. |
| Sectors | Chemicals Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | https://gtr.ukri.org/projects?ref=studentship-1962581 |