Dissecting heterogeneity in human pluripotent stem cell-derived dopaminergic neuronal grafts.
Lead Research Organisation:
University of Edinburgh
Department Name: MRC Centre for Regenerative Medicine
Abstract
Dissecting heterogeneity in human pluripotent stem cell-derived dopaminergic neuronal grafts.
People |
ORCID iD |
| Tilo Kunath (Primary Supervisor) | |
| Craig Leighton (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/R502327/1 | 01/09/2017 | 28/08/2021 | |||
| 1978637 | Studentship | MR/R502327/1 | 01/09/2017 | 31/05/2021 | Craig Leighton |
| Description | MRC Flexible Supplement funds |
| Amount | £3,780 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 11/2019 |
| Description | UCB NPIF Funding |
| Amount | £5,000 (GBP) |
| Organisation | UCB Pharma |
| Sector | Private |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 09/2021 |
| Description | UCB research partnership |
| Organisation | UCB Pharma |
| Department | Cellular Sciences - UCB Pharma |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | My project is the second project in the lab which UCB has part funded. We have developed an in-vitro cell model of Parkinson's disease which is being utilised to explore potential treatments, as well as identifying potential biomarkers of the condition. The later aim is the main focus of my PhD and I am currently working towards this goal, to date optimising a super-resolution technique for examining pathological protein oligomers in conditioned medium. |
| Collaborator Contribution | UCB have provided funding and pre-formed alpha synuclein fibrils which are used to induce alpha synuclein pathology within our cell model of Parkinson's disease. They have also provided advice and guidance, and have agreed to set up bimonthly meetings to monitors it's progress. |
| Impact | So far there are no tangible outputs from the collaboration, however, it is still in it's infancy. |
| Start Year | 2019 |
| Description | Edinburgh Research Interest Group - Parkinson's UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The event normally takes the form of a lecture by a prominent researcher in the field of Parkinson's, followed by coffee and tea where the patients and carers are encouraged to asks students about their research and discuss the current research landscape and what is being done to help treat their condition. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | School Visit (Castlebrae high school) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | the centre for regenerative medicine is involved in a lot with the local school and I have often helped show the students around the facility. I am also part of a group which goes to the school each week to help the pupils with exam preparation for science exams. |
| Year(s) Of Engagement Activity | 2018,2019 |