Photochemical Approaches to Cyclobutane Functionalization and Cyclopropane Cascade Reactions
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
This project will investigate the formation and further reactions of small ring systems.
For example maleic anhydride derivatives will be investigated in a variety of [2+2] cycloaddition reactions with a range of alkynes. These cyclobutenes will then be investigated as scaffolds for further elaboration as drug discovery libraries in collaboration with UCB. In a related study amino-cyclopropane derivatives will be investigated as substrates to undergo novel radical cyclisation cascade reactions to generate a range of complex scaffolds as possible drug discovery scaffolds.
For example maleic anhydride derivatives will be investigated in a variety of [2+2] cycloaddition reactions with a range of alkynes. These cyclobutenes will then be investigated as scaffolds for further elaboration as drug discovery libraries in collaboration with UCB. In a related study amino-cyclopropane derivatives will be investigated as substrates to undergo novel radical cyclisation cascade reactions to generate a range of complex scaffolds as possible drug discovery scaffolds.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| NE/W503174/1 | 01/04/2021 | 31/03/2022 | |||
| 2056622 | Studentship | NE/W503174/1 | 01/10/2017 | 31/12/2021 | Mark Deeprose |