Activating and directing post-translational modification by the design and synthesis of heterobifunctional small molecules
Lead Research Organisation:
Institute of Cancer Research
Department Name: Division of Cancer Therapeutics
Abstract
Overall aim:
Demonstrate that heterobifunctional ligands can enable selective post-translational modification of a target protein by bringing together two protein components.
Required steps:
Design and synthesis of heterobifunctional ligands
Test for binding to individual proteins; check cell permeability; refine design as necessary
Check for phosphorylation of target protein
Confirm activation by looking at downstream or phenotypic effects
Demonstrate that heterobifunctional ligands can enable selective post-translational modification of a target protein by bringing together two protein components.
Required steps:
Design and synthesis of heterobifunctional ligands
Test for binding to individual proteins; check cell permeability; refine design as necessary
Check for phosphorylation of target protein
Confirm activation by looking at downstream or phenotypic effects
People |
ORCID iD |
| Charles Robertson (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/R01583X/1 | 01/10/2018 | 30/09/2025 | |||
| 2119117 | Studentship | MR/R01583X/1 | 01/10/2018 | 30/09/2022 | Charles Robertson |
| Description | iCASE and BRC training session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | A training session for all students who are part of the iCASE scheme and the BRC-funded students to provide some networking and skills training specific to your circumstances where you are working between different cultures and with multiple supervisors and priorities to manage. |
| Year(s) Of Engagement Activity | 2020 |