DISSECTING THE RELATIONSHIP BETWEEN PHOSPHINOSITIDE3-KINASE ACTIVITY AND L-SELECTIN EXPRESSION BY LEUCOCYTES
Lead Research Organisation:
Cardiff University
Department Name: School of Medicine
Abstract
The classical view of L-selectin function in T cell homing was restricted to naïve and central memory trafficking to lymph nodes; however our new data has overthrown this dogma. We have shown that CD8+ T cell dependent virus clearance from infected organs is limited by the level of L-selectin expression on early stage effector T cells and maintaining high L-selectin levels (gain of function) boosts CD8+T cell immunity.
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/S506990/1 | 01/10/2018 | 30/09/2022 | |||
2125608 | Studentship | BB/S506990/1 | 01/10/2018 | 30/09/2022 |