Novel Fluorophore synthesis for biological imaging applications
Lead Research Organisation:
University of Birmingham
Department Name: School of Chemistry
Abstract
The project involves the synthesis of novel fluorophores based on a triphenylene core and how changes to the functional groups present on the molecules will affect the properties exhibited. The project will also go onto exploring the different applications of the compounds and how they can be utilised as a detection tool in imaging applications. For example, by conjugating fluorophores to a biological entity such as an antibody, microscopy can be used to visualise the fluorescence emitted when the antibody is bound to a target protein. This can be done using a fluorescence, multi-photon or confocal microscope. The project will also explore how the use of transition metals incorporating into the fluorophores will change the photophysical properties of the material.
Organisations
People |
ORCID iD |
| Jon Preece (Primary Supervisor) | |
| Sareena Sund (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/R513167/1 | 01/10/2018 | 30/09/2023 | |||
| 2271977 | Studentship | EP/R513167/1 | 01/10/2019 | 29/12/2022 | Sareena Sund |
| Description | The conjugation chemistry of novel compounds has so far been achieved and subsequent analysis so far have proved successful |
| Exploitation Route | The outcome of this work can aid in the development of protein detection which in the future can be used in medical applications |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Cyto travel award 2022 |
| Amount | $800 (USD) |
| Organisation | International Society for the Advancement of Cytometry (ISAC) |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 04/2022 |
| End | 06/2022 |
| Title | LUMINESCENT COMPOUNDS |
| Description | Polycyclic aromatic hydrocarbon derivatives represented by the following general formula: (I) wherein R independently represents an aromatic group and/or an aliphatic group; Q is one of a cyclic aliphatic hydrocarbon, a cyclic aromatic hydrocarbon, a polycyclic hydrocarbon, a polycyclic aromatic hydrocarbon, and/or a fused polycyclic aromatic hydrocarbon; wherein the substituents independently comprise one or more of a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a carbon atom, an oxygen atom (e.g. an alkylated oxygen atom), a nitrogen atom (e.g. an alkylated nitrogen atom), a cyano group, a nitro group, an alkyl group and/or an aryl group; p is an integer of 1 to 2; q is an integer of 1 to 4; Y1 and Y2 independently represent one or more of a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a carbon atom, an oxygen atom (e.g. an alkylated oxygen atom), a nitrogen atom (e.g. an alkylated nitrogen atom), a cyano group, a nitro group, an alkyl group and/or an aryl group; and x is an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more. |
| IP Reference | WO2019180445 |
| Protection | Patent granted |
| Year Protection Granted | 2019 |
| Licensed | Yes |
| Impact | Polycyclic aromatic hydrocarbon derivatives represented by the following general formula: (I) wherein R independently represents an aromatic group and/or an aliphatic group; Q is one of a cyclic aliphatic hydrocarbon, a cyclic aromatic hydrocarbon, a polycyclic hydrocarbon, a polycyclic aromatic hydrocarbon, and/or a fused polycyclic aromatic hydrocarbon; wherein the substituents independently comprise one or more of a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine |
| Company Name | CHROMATWIST LTD |
| Description | ChromaTwist is a leader in large Stokes shift organic fluorescent dyes which are excited across the UV and the blue leading to bright tuneable emission across the entire visible spectrum. Our patented innovative molecular technology platform coupled to our modular and scalable chemistry is allowing the development of our fluorophores to further push the boundaries of applications in the healthcare sector through their application in bio-sensing (e.g. flow cytometry) and bio-imaging (e.g. multiphoton microscopy). |
| Year Established | 2018 |
| Impact | ChromaTwist UV fluorescent probes for Flow Cytometry are powered by a patented technology platform allowing the development of new 355 nm (and 405 nm) excited probes that emit across the entire visible spectrum to further enhance multiplexing capabilities which will ultimately give users more choice. |
| Description | STEM talk in school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I gave a talk to year 8 pupils about careers in STEM. My talk outlined my journey so far and my experiences. |
| Year(s) Of Engagement Activity | 2021 |