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Dissecting the interplay between cardiomyocytes and fibroblasts using human stem cell models of disease

Lead Research Organisation: University of Birmingham
Department Name: Institute of Cardiovascular Sciences

Abstract

Project aims: 1. Develop and optimise methodology for 2D co-culture and high resolution electrophysiological phenotyping of human pluripotent stem cell-cardiomyocytes (hPSC-CM) and cardiac fibroblasts, 2. Characterise the effect of cardiomyocyte-fibroblast coupling on electrical function and calcium handling, 3. Utilise Cas9/CRISPR technology to generate hPSC-CM lines expressing common sarcomeric gene mutations and asses their effects on electrophysiological and mitochondrial function in cardiomyocyte-fibroblast co-cultures.

People

ORCID iD
Caitlin Hall (Student)

Publications

10 25 50
publication icon
Hall C (2021) Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease. in Journal of the American Heart Association

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013913/1 30/09/2016 29/09/2025
2282524 Studentship MR/N013913/1 30/09/2019 28/06/2023 Caitlin Hall