Dissecting the interplay between cardiomyocytes and fibroblasts using human stem cell models of disease
Lead Research Organisation:
University of Birmingham
Department Name: Institute of Cardiovascular Sciences
Abstract
Project aims: 1. Develop and optimise methodology for 2D co-culture and high resolution electrophysiological phenotyping of human pluripotent stem cell-cardiomyocytes (hPSC-CM) and cardiac fibroblasts, 2. Characterise the effect of cardiomyocyte-fibroblast coupling on electrical function and calcium handling, 3. Utilise Cas9/CRISPR technology to generate hPSC-CM lines expressing common sarcomeric gene mutations and asses their effects on electrophysiological and mitochondrial function in cardiomyocyte-fibroblast co-cultures.
Organisations
People |
ORCID iD |
| Davor Pavlovic (Primary Supervisor) | |
| Caitlin Hall (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013913/1 | 01/10/2016 | 30/09/2025 | |||
| 2282524 | Studentship | MR/N013913/1 | 01/10/2019 | 29/06/2023 | Caitlin Hall |