Investigating the Agonistic Requirements of anti human 4-1BB monoclonal antibodies
Lead Research Organisation:
University of Southampton
Department Name: Cancer Sciences
Abstract
In recent decades, immunotherapy has emerged as a promising therapeutic approach for cancer. A key factor to its success has been the ability to use monoclonal antibodies (mAbs) to activate cytotoxic T cell responses against tumours by blocking T cell inhibitory molecules. However, this approach is only effective in a fraction of tumour types and many patients do not respond, highlighting the need for novel immune-activating therapies to improve therapeutic outcomes. mAbs targeting the immunostimulatory receptor 4-1BB hold promise as therapeutics for cancer, however insight into the properties modulating their efficacy as immune agonists is lacking. For mAbs targeting other receptors of the same family as 4-1BB, certain molecular characteristics, such as epitope and mAb isotype, have been shown to influence the strength of their agonistic activity.
Organisations
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N014308/1 | 01/10/2016 | 30/09/2025 | |||
2448144 | Studentship | MR/N014308/1 | 01/10/2020 | 30/09/2024 | Alba Gonzalez-Garcia |