Meta-omics to uncover rumen helminth-microbiome interactions
Lead Research Organisation:
Aberystwyth University
Department Name: IBERS
Abstract
Helminth parasites are responsible for >55% of livestock diseases representing a major threat to global food security and food borne disease, with control being through anthelmintic drugs due to vaccine failure. A major obstacle to improving control options is a lack of a holistic understanding of host-parasite interactions. Links between helminth infection, the host and its microbiome are only at a basic level of understanding. Recent preliminary work (RM) has suggested that there is a substantial contribution of parasite-mediated changes in the ruminant gut microbiota following investigation into the rumen fluke, Calicophoron daubneyi, within an in vitro rumen model. Additional preliminary evidence (RM/SH) suggests a direct role of rumen fluke extracellular vesicles (EVs) in shaping the microbial communities of the host rumen. Therefore, understanding the impact of parasitic helminths on rumen functionality is a must to prevent losses to animal productivity and rumen functionality.
A combined meta-omics approach will reveal the interaction between the host rumen microbiome and the rumen fluke and/or secreted EVs whilst generating an understanding of rumen functionality following exposure to the parasite or parasite derived EVs.
A combined meta-omics approach will reveal the interaction between the host rumen microbiome and the rumen fluke and/or secreted EVs whilst generating an understanding of rumen functionality following exposure to the parasite or parasite derived EVs.
Organisations
People |
ORCID iD |
Russell Morphew (Primary Supervisor) | |
Jacob Leonard (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T008776/1 | 01/10/2020 | 30/09/2028 | |||
2600817 | Studentship | BB/T008776/1 | 01/10/2021 | 30/09/2025 | Jacob Leonard |