Stability of dry powder formulations used in drug delivery to the lungs studied one particle at a time
Lead Research Organisation:
University of Bristol
Department Name: Chemistry
Abstract
The PhD project will involve the use of a range of conventional tools for characterising formulation
performance and stability along with novel single aerosol particle tools developed at the
University of Bristol.
The specific objectives of the PhD will be to:
1. Develop a range of test formulations that exhibit different stability behaviours,
characterised by their fine particle aerodynamic performance.
2. Assess how changes in storage conditions of the inhalers within a closed secondary pack
(e.g., foil overwrap) affect the rate of change.
3. Quantify how changes in particulate properties at the microscale may be implicated in
these macro level changes.
4. Develop models for predicting magnitude of changes over shelf-life.
5. Suggest manufacturing control strategy to manage instability.
performance and stability along with novel single aerosol particle tools developed at the
University of Bristol.
The specific objectives of the PhD will be to:
1. Develop a range of test formulations that exhibit different stability behaviours,
characterised by their fine particle aerodynamic performance.
2. Assess how changes in storage conditions of the inhalers within a closed secondary pack
(e.g., foil overwrap) affect the rate of change.
3. Quantify how changes in particulate properties at the microscale may be implicated in
these macro level changes.
4. Develop models for predicting magnitude of changes over shelf-life.
5. Suggest manufacturing control strategy to manage instability.
People |
ORCID iD |
Jonathan Reid (Primary Supervisor) | |
Anna Catton (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
EP/S023593/1 | 01/04/2019 | 30/09/2027 | |||
2886523 | Studentship | EP/S023593/1 | 01/10/2023 | 30/09/2027 | Anna Catton |