Immunity to multiple pathogens: identification of a fungal immune receptor in barley to ascomycete and basidiomycete fungi
Lead Research Organisation:
University of East Anglia
Department Name: Sainsbury Laboratory
Abstract
The majority of plants are resistant to the majority of pathogens that exist in nature. In contrast, it is the minority of interactions that permit lifecycle completion of the pathogen. The proclivity of nonhost resistance to the majority of pathogens suggests plants have a substantial capacity to resist various pathogens and/or that pathogens must make crucial adaptations to proliferate on a plant species. We have identified a resistance locus that conditions resistance to the ascomycete and basidiomycete fungi Magnaporthe oryzae and Puccinia striiformis f. sp. tritici. These two pathogens cause significant impact on global wheat and rice production, and the possibility that the same immune receptor conditions multiple pathogen recognition has profound implications in plant pathology. The project will involve the isolation of the fungal immune receptor through a combination of map-based cloning, association genetics, and bioinformatics.
People |
ORCID iD |
Matthew Moscou (Primary Supervisor) | |
Samuel Holden (Student) |
Publications
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M011216/1 | 30/09/2015 | 31/03/2024 | |||
1786354 | Studentship | BB/M011216/1 | 30/09/2016 | 30/03/2021 | Samuel Holden |
Description | Fine-mapping a genetic locus providing resistance to wheat stripe rust in barley (Rps8). Confirmation that at least one gene within the locus is necessary for resistance, via mutant screens. An analysis of this gene's evolutionary history, which revealed it is a recent innovation within the grasses. This involved the sequencing of a closely related species' genome for the first time (Ecdeiocolia monostachya) Identification of a completely new locus, required for the function of Rps8 |
Exploitation Route | Continuing the research into whether Rps8 protects against alternative pathogens. Studying how exactly Rps8 provides resistance to stripe rust, and how its partner gene is involved. Further work using the recently sequenced Ecdeiocolia monostachya genome to assess the evolution of other traits in the grasses |
Sectors | Agriculture Food and Drink |
Description | Silvio |
Organisation | University of Bologna |
Country | Italy |
Sector | Academic/University |
PI Contribution | Technical training and expertise, helping our partners to clone their genes of interest |
Collaborator Contribution | Access to a TILLING population of barley, which we are using to identify our own genes of interest |
Impact | None yet |
Start Year | 2017 |
Description | Presented at PAG |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | I attended the Plant and Animal Genome conference and gave a talk summarising my work, as well as other work produced within the research group |
Year(s) Of Engagement Activity | 2020 |
Description | Talk at ENPER |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | I gave a talk at the ENPER conference about the results of my research |
Year(s) Of Engagement Activity | 2018 |