Understanding the mechanism and cost of phage resitance in the Enterobacteriaceae
Lead Research Organisation:
University of Leicester
Department Name: Genetics
Abstract
With the ever-growing threat of antibiotic resistant infections, there is a critical need for alternatives to antibiotics. Bacteriophage are a group of viruses that specifically infect bacteria and can be used as antimicrobial agents against bacterial infections. Phages and bacteria are locked in a never-ending evolutionary arms race, whereby bacteria develop resistance to phages and then phages overcome this resistance. For phages to be used as therapeutic agents it is critical to understand the mechanism of phage resistance and if different resistance mechanisms occur with different phages. Furthermore, for phages that are capable of infecting bacteria of different bacterial hosts, it is not known if the same mechanism of resistance evolves in different hosts.
Organisations
Publications
Besler I
(2020)
Genome Sequence and Characterization of Coliphage vB_Eco_SLUR29.
in PHAGE (New Rochelle, N.Y.)
LomelĂ-Ortega CO
(2021)
Isolation and characterization of vibriophage vB_Vc_SrVc9: an effective agent in preventing Vibrio campbellii infections in brine shrimp nauplii (Artemia franciscana).
in Journal of applied microbiology
Thummeepak R
(2020)
Essential Gene Clusters Involved in Copper Tolerance Identified in Acinetobacter baumannii Clinical and Environmental Isolates
in Pathogens
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/M01116X/1 | 30/09/2015 | 31/03/2024 | |||
1898562 | Studentship | BB/M01116X/1 | 01/10/2017 | 31/12/2021 | Lucy Gannon |