EPSRC-Royal Society fellowship engagement (2013):Visualising thoughts: ESR measurement of nanodiamonds targetted to neural structures
Lead Research Organisation:
University of Oxford
Department Name: Physiology Anatomy and Genetics
Abstract
Please refer to attached Royal Society application
Planned Impact
Please refer to attached Royal Society application
Publications
Grant SD
(2019)
Adapting the 3D-printed Openflexure microscope enables computational super-resolution imaging.
in F1000Research
Miles B
(2016)
All-Optical Method for Characterizing Individual Fluorescent Nanodiamonds
in ACS Photonics
Cairns G
(2024)
An open-source alignment method for multichannel infinite-conjugate microscopes using a ray transfer matrix analysis model
in Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Johnstone GE
(2019)
Nanodiamonds enable adaptive-optics enhanced, super-resolution, two-photon excitation microscopy.
in Royal Society open science
Description | We have developed microscope technologies that integrate multiple recently developed experimental approaches. We have found that small particles of diamond are excellent markers for microscopy. They do not degrade over time, so some of the measurement approaches, which require tens or even hundreds of conventional images to generate computationally enhanced data are more effective when we use nanodiamond. We are also developing general approaches to designing microscope hardware with mutliple modes of operation and we are consistently improving how we communicate these methods to the research community. |
Exploitation Route | We are just now developing the experimental approaches that will be disseminated - we are currently developing potential collaborations with biological researchers in the fields of anti-microbial resistance and with cancer research with the aim of disseminating our techniques both to the wider research community and also, ideally, to industry. |
Sectors | Agriculture Food and Drink Education Electronics Environment Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
Description | Direct Wavefront Sensing for Efficient Measurement of Electronic Spin in Nanodiamond |
Amount | £14,676 (GBP) |
Funding ID | RG170189 |
Organisation | The Royal Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2019 |
Description | EPSRC Quantum Technologies Grant |
Amount | £18,068 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2014 |
End | 03/2015 |
Description | Follow-up Program of the JSPS Frontiers of Science (FoS) Symposium. |
Amount | ¥252,000 (JPY) |
Funding ID | JSPS/ IRI-2/19001 |
Organisation | Japan Society for the Promotion of Science (JSPS) |
Sector | Public |
Country | Japan |
Start | 08/2019 |
End | 10/2020 |
Description | University of Strathclyde Chancellors Fellowship |
Amount | £250,000 (GBP) |
Organisation | University of Strathclyde |
Sector | Academic/University |
Country | United Kingdom |
Start | 07/2016 |
End | 08/2021 |
Description | Collaboration with NPL on quantum sensing with nanodiamond |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are providing expertise on microscopy design and quantum sensing measurements with nanodiamond. |
Collaborator Contribution | They are providing chemistry and biochemistry expertise relating to optical generation of radicals. |
Impact | Early stage collaboration, no outputs yet. Multidisciplinary: Physics, biology, chemistry |
Start Year | 2021 |
Description | IBIN Collaboration with Dr Izzy Jayasinghe |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We supplied macrophages for use with Dr. Jayasinghe's localisation microscopy technique |
Collaborator Contribution | They provided a protocol for labelling nanodiamond and imaging parameters to ensure blinking. |
Impact | We obtained ~£5k funding from the IBIN consortium based in Kings College London for a travel grant to test the imaging technique. |
Start Year | 2019 |
Description | Nanodiamond imaging and characterisa\tion |
Organisation | University of Bristol |
Department | MRC Integrative Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provided material and co-wrote the paper (10.1021/acsphotonics.5b00732) that arose from this partnership |
Collaborator Contribution | Provided the imaging technology, performed the experiments, co-wrote the paper |
Impact | Paper: DOI 10.1021/acsphotonics.5b00732 |
Start Year | 2015 |