Using genetic variability in whole transcriptome expression in cells and tissues to understand the pathogenesis of Parkinson's and Alzheimer's disease

Lead Research Organisation: University College London
Department Name: Institute of Neurology

Abstract

Parkinson's and Alzheimer's disease (PD & AD) are common diseases that affect the brain, causing certain cells to die. When these cells are lost people experience, amongst other problems, difficulty remembering recent events in the case of AD and difficulties moving in the case of PD. At the moment these diseases affect over 1 million people in the United Kingdom with a devastating impact on patients and their families. Since both these diseases become more common with age, the number of sufferers is likely to increase as the number of elderly people rises in the UK. Unfortunately, at the moment we know relatively little about why certain people suffer from these diseases and until we do it is hard for researchers and doctors to develop effective treatments.
In the past 3 years scientists have been able to show that some individuals have common changes in their DNA (the instruction manual for all the building blocks needed to make the human body) that put them at higher risk of developing these conditions. Although this has been an amazing step forward, it has not been easy for scientists to understand how these changes in the DNA, termed genetic risk factors, act to help cause disease. Many people believe that one way in which these genetic risk factors might cause disease is by changing how much or the way in which particular genes (the basic building blocks) are expressed in brain cells. In order to check this, researchers need to make measurements about the genetic variation an individual carries and link this information to the genes they express in their cells.
Although this type of investigation is particularly challenging for diseases that affect the brain, it is possible and meeting those challenges is the aim of this project. One of the difficulties is accurately measuring the amount of the gene expressed in the right cells in the brain. The brain is extremely complex and even within a single region there are many different types of cells. We will address this problem by making use of a technique called laser capture microdissection to obtain pure collections of cells from brain regions relevant to PD and AD. In this technique, using very thin slices of the human brain tissue, we shoot out just the cells we are interested in collecting with a high power laser and then extract the RNA (the gene copies) from the pellets we shoot out. Another advance is the advent of new technology for measuring all the genes expressed in a single cell type or tissue sample. This technology is called "RNA-seq" or "whole transcriptome sequencing" and it allows us to measure all kinds of gene product from any gene. It also allows us to measure the relative quantities of alternative versions of the same gene, and to measure these quantities in such a way that the influence of genetic risk factors can be more sensitively detected by directly comparing the relative product quantities in individuals who happen to have both a "good" and a "bad" copy of a given genetic variant.
We believe that we are in an ideal position to complete this project and so add important insights to the understanding of PD and AD. We already have many of the RNA samples needed to perform this study and while some new RNA samples will be created during the project, through our close collaboration with the MRC Sudden Death Brain and Tissue Bank in Edinburgh we have the brain samples needed to do this (all of which have been donated for research). We have also already carried out extensive analysis of DNA from these samples, which means that the new information we generate during this grant can be quickly and cost-effectively added to existing sources of data in order to progress this research. As a final benefit, all the data we will generate on the human brain will be made publically available so that other scientists interested in understanding how the human brain works in health and disease can use this information.

Technical Summary

The aim of this study is to determine the effect of genetic risk factors on whole transcriptome expression in brain regions and cell types most vulnerable to Parkinson's and Alzheimer's disease (PD and AD) in order to understand the pathogenic processes underlying these conditions. This project is inspired by the recent discovery of 15 new genetic risk variants for PD and 13 new loci for AD. However, knowing the genomic position of risk variants is not equivalent to knowing how they act in terms of the underlying molecular processes or where they act in terms of the regional or cellular location. We aim to address both these issues. Using control post-mortem human brain tissue originating from 150 individuals, we will use expression quantitative trait locus (eQTL) mapping and allele-specific expression (ASE) analysis to identify loci that both change disease risk and regulate the expression of specific gene transcripts within specific tissues/cells. We will conduct these studies within the tissues and cells most relevant to PD and AD, namely the substantia nigra, hippocampus, temporal cortex, dopaminergic neurons, CA1 neurons, pyramidal neurons and astrocytes. Existing exome sequencing and SNP array data will be combined with whole transcriptome RNA sequencing data generated on the Illumina HiSeq2000 platform for downstream analysis. These two types of information - genetic variation and transcript expression - will be used for eQTL mapping in tissues and ASE analysis in cells. In both cases the eQTLs identified will be annotated for disease-relevance in the first instance. All the data generated by this project will be publicly released as both raw data files for re-analysis and processed information suitable for non-expert users through NCBI's Gene Expression Omnibus repository and Phenotype-Genotype Integrator sites. Thus, we will generate novel disease-relevant findings and provide the neuroscience community with a world-class resource.

Planned Impact

The goal of this work is to develop comprehensive databases which allow the interpretation of the genome wide association studies (GWAS) for the two most common neurodegenerative diseases, Parkinson's and Alzheimer's disease (PD and AD). In this way, we will improve our understanding of the pathogenic processes underlying these diseases and in the long term improve the diagnosis and treatment of patients struggling to cope with these debilitating diseases. Reaching this goal will require many intermediate steps and we describe who we envisage using our research findings and how this data will help them.

Researchers interested in the follow up of GWAS data: This study was designed to improve our understanding of the molecular mode of action and cellular location in which genetic risk variants for PD and AD act. Therefore, the most obvious users of our data are the original AD and PD consortia. However, the results of this study will also be useful for the interpretation of GWAS for other neurological and psychiatric disorders, making it relevant to researchers interested in the results of GWAS in frontotemporal dementia, epilepsy, depression and schizophrenia to name a few. Since we are publicly releasing all findings through the NCBI's searchable database, Phenotype-Genotype Integrator, we envisage other less specialist researchers also accessing and using the data. These individuals include clinicians, epidemiologists and drug companies interested in following up GWAS hits for clinical trial design or biomarker development.

Researchers interested in the creation and use of in vitro model systems: The cell-specific whole transcriptome sequencing data produced in this project will be a baseline for the detailed molecular assessment of stem cell-based disease models. We will work collaboratively with researchers in the University of Edinburgh (Dr. Kunath & Dr. Chandran) and Cambridge University (Dr. Livesey) to identify the strengths and weaknesses of existing cell models and work to improve the accuracy of these systems. Thus, we will contribute to the development of new research tools for use by the neuroscience research community within universities and in the private setting.

Basic neurobiologists: The large gene expression data sets we are producing will provide insights into other aspects of basic neurobiology. For example, it will be of value to those researchers interested in analysing sex differences in transcript expression. Using this data it will be possible to improve our understanding of the basis of well recognised differences in the incidence, presentation and response to treatment of many neurological disorders. This could in turn contribute to the drive towards individualised patient assessment and care.

Bioinformaticians & statistical geneticists: The raw genotyping, exome and RNA sequencing data will be used by statistical genetics and bioinformatics wishing to test and develop new statistical and analytical methods. In particular, the existence of paired exome sequencing and SNP array data will allow researchers to objectively test and improve methods for the imputation of genetic data. Therefore, we will directly contribute to one of the MRC's stated aims, the training of more researchers and clinicians in bioinformatics.

Charities & patient groups: The discovery of genetic risk variants for PD and AD represent one of the most significant steps forward in the understanding of these diseases in the last 10 years. Therefore, they are hugely important to patients and carers who desperately want to see progress in the diagnosis and treatment of their diseases. From our own experience of hosting visits for Parkinson's Disease UK, Alzheimer's Research UK and the Michael J Fox Foundation, we recognise the importance of engaging with patients and communicating the findings generated from our research in order to maintain hope, create novel resources and improve the uptake of clinical trials.

Publications

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Bandres-Ciga S (2019) The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease. in Movement disorders : official journal of the Movement Disorder Society

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Blauwendraat C (2019) Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and a-synuclein mechanisms. in Movement disorders : official journal of the Movement Disorder Society

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Chelban V (2021) Spastic paraplegia preceding PSEN1-related familial Alzheimer's disease. in Alzheimer's & dementia (Amsterdam, Netherlands)

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Chelban V (2017) Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination. in American journal of human genetics

 
Title Additional file 3 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description The second one corresponds to k-means. Both on UKBEC datasets. Values higher than 20 are set to 20. Colors at the top of columns correspond to tissues, the tissue legend is at the bottom of columns and cell marker gene set used on the right side. (JPG 1177 kb) 
Type Of Art Film/Video/Animation 
Year Produced 2017 
URL https://springernature.figshare.com/articles/figure/Additional_file_3_of_An_additional_k-means_clust...
 
Title Additional file 3 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description The second one corresponds to k-means. Both on UKBEC datasets. Values higher than 20 are set to 20. Colors at the top of columns correspond to tissues, the tissue legend is at the bottom of columns and cell marker gene set used on the right side. (JPG 1177 kb) 
Type Of Art Film/Video/Animation 
Year Produced 2017 
URL https://springernature.figshare.com/articles/figure/Additional_file_3_of_An_additional_k-means_clust...
 
Title Additional file 4 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Heat-maps showing -l o g 10(p-values) from Ficher's Exact test on significant concentration of specific cell marker gene sets (rows) on each tissue module (columns). The one within the Additional file 1 corresponds to the standard WGCNA. (JPG 1198 kb) 
Type Of Art Film/Video/Animation 
Year Produced 2017 
URL https://springernature.figshare.com/articles/figure/Additional_file_4_of_An_additional_k-means_clust...
 
Title Additional file 4 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Heat-maps showing -l o g 10(p-values) from Ficher's Exact test on significant concentration of specific cell marker gene sets (rows) on each tissue module (columns). The one within the Additional file 1 corresponds to the standard WGCNA. (JPG 1198 kb) 
Type Of Art Film/Video/Animation 
Year Produced 2017 
URL https://springernature.figshare.com/articles/figure/Additional_file_4_of_An_additional_k-means_clust...
 
Description Attachment with Genomics England
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Joint Lead for Bioinformatics in Neurology GeCIP
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description EU Joint Programme Grant
Amount € 530,000 (EUR)
Organisation JPND Research 
Sector Academic/University
Country Global
Start 01/2014 
End 01/2017
 
Description Project Grant
Amount £1,300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2013 
End 03/2016
 
Description Project Grant
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2010 
End 03/2013
 
Description Wellcome Biomedical Resource Grant
Amount £200,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 10/2019
 
Title A web-based tool for quality control of eQTL data 
Description This is a web-based tool to allow users to check whether reported eQTLs may be due to systematic errors arising from the presence of polymorphisms within expression microarray probes. 
Type Of Material Technology assay or reagent 
Year Produced 2012 
Provided To Others? Yes  
Impact This is currently being used by our collaborators based in the NIH, but will soon be made publicly available. It has resulted in the identification of a significant number of false positive results. 
 
Title A web-based tool for eQTL analysis and expression profiles 
Description We have created a web-based tool to allow researchers to access the eQTL data we have generated and expression profiles in human brain. 
Type Of Material Biological samples 
Year Produced 2013 
Provided To Others? Yes  
Impact This is presently being used by groups within KCL and UCL to follow up GWAS results. 
 
Title Database on genetic variation in neurologically normal individuals over the age of 60 years old 
Description I contributed to the HEXdatabase which provides information on genetic variation in individuals with no evidence of a neurological disorder. 
Type Of Material Biological samples 
Year Produced 2016 
Provided To Others? Yes  
Impact This tool will be released on the Alzform website. 
 
Title Genome-wide gene expression in 10 human brain regions 
Description This is a database of exon-specific gene expression generated from over 800 RNA samples extracted from post-mortem human brain tissue. 
Type Of Material Biological samples 
Provided To Others? No  
Impact This collection of data when released will provide researchers working in the field of neuroscience comprehensive imformation on the expression of all genes within multiple human brain regions. 
 
Title Human genome expression database 
Description Gene expression database. http://caprica.genetics.kcl.ac.uk:51519/BRAINEAC/ 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2010 
Provided To Others? Yes  
Impact It has been accessed several thousand times and data from it incorporated into at least 100 publications 
URL http://smarturl.it/braineac
 
Title StemBANCC 
Description Stem cell biobank. Freely available. 
Type Of Material Cell line 
Year Produced 2012 
Provided To Others? Yes  
Impact This has been a successful application and many drug companies are using stem cell lines supplied by our group 
URL http://stembancc.org
 
Title Additional file 1 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Lists tissues, samples and genes used for the creation of each GCN. (CSV 4 kb) 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
URL https://springernature.figshare.com/articles/dataset/Additional_file_1_of_An_additional_k-means_clus...
 
Title Additional file 1 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Lists tissues, samples and genes used for the creation of each GCN. (CSV 4 kb) 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
URL https://springernature.figshare.com/articles/dataset/Additional_file_1_of_An_additional_k-means_clus...
 
Title Additional file 2 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Includes comparative results of standard WGCNA and k-means on simulated data. (CSV 4 kb) 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
URL https://springernature.figshare.com/articles/dataset/Additional_file_2_of_An_additional_k-means_clus...
 
Title Additional file 2 of An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks 
Description Includes comparative results of standard WGCNA and k-means on simulated data. (CSV 4 kb) 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
URL https://springernature.figshare.com/articles/dataset/Additional_file_2_of_An_additional_k-means_clus...
 
Description Age-related changes in gene expression in human brain 
Organisation Wellcome Trust
Department Multiple Tissue Human Expression Resource (MuTHER) consortium
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided gene expression data on human brain.
Collaborator Contribution They have provided gene expression data relating to multiple other human tissues.
Impact There is a paper in submission with Genome Research
Start Year 2011
 
Description Collection and analysis of control human post-mortem brain tissue 
Organisation University of Edinburgh
Department Neuropathology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We have supplied our collaborators with information regarding the degree of RNA preservation within banked control human brain tissue.
Collaborator Contribution This collaboration has allowed to collect high quality control human brain tissue for analysis.
Impact This collaboration has allowed us to build a database of exon-specific gene expression in multiple human brain regions.
Start Year 2009
 
Description Genetic risk variants for mesio-temporal lobe epilepsy 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided regional eQTL data and total RNA extracted from human brain tissue originating from neurologically normal individuals.
Collaborator Contribution They have identified risk SNPs for mesio-temporal lobe epilepsy.
Impact There is presently a paper in submission with Nature Genetics.
Start Year 2011
 
Description PARK7 gene structure and expression 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Expression and RNAseq data and data interpretation relating to PARK7 expression in human brain
Collaborator Contribution Expertise regarding the structure and function of PARK7
Impact Manuscript in preparation
Start Year 2012
 
Description The International Parkinson Disease Genomics Consortium 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution This is a hugem consortium. WE are founder members. WE help manage the consortium, we obtain grant funds for it and we contribute patient samples and data
Collaborator Contribution They contribute in the same way we do
Impact Huge number of publications: too many to list. Genetics, Gene expression and Neurology
Start Year 2007
 
Description The International Parkinson Disease Genomics Consortium 
Organisation Pitié-Salpêtrière Hospital
Country France 
Sector Hospitals 
PI Contribution This is a hugem consortium. WE are founder members. WE help manage the consortium, we obtain grant funds for it and we contribute patient samples and data
Collaborator Contribution They contribute in the same way we do
Impact Huge number of publications: too many to list. Genetics, Gene expression and Neurology
Start Year 2007
 
Description Whole genome expression analysis for the assessment of hESC-derived neuronal maturation 
Organisation University of Edinburgh
Department Centre for Clinical Brain Sciences (CCBS)
Country United Kingdom 
Sector Academic/University 
PI Contribution I have performed the expression and splicing analysis of these samples.
Collaborator Contribution They have provided samples of hESCs, neural precursors and hESc-derived neurons. They have also provided expertise on the process of neural differentiation.
Impact We currently have a paper in submission to Human Molecular Genetics. This collaboration is multidisciplinary with specialist cell and developmental biologists.
Start Year 2011
 
Description Whole genome expression database 
Organisation National Institute on Aging
Department Laboratory of Neurogenetics
Country United States 
Sector Public 
PI Contribution We are just abouhttp://bit.ly/braineac (ignore certificate warning) username: UKBEC password: BraineacNOW t to relase this database to the general public
Collaborator Contribution We worked with our Us collaborators on this project (Singleton/Cookson): about half the work each
Impact Just search Ryten plus Singleton on pubmed These are the current PMID 23223016, 23177596, 22892372 , 22777693, 22723018, 22433082, 21738488 , 21292315
Start Year 2009
 
Description Whole genome expression in iPS-derived neurons in health and disease 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We have performed the analysis of geen expression and splicing in these samples.
Collaborator Contribution It has resulted in the provision of unique samples for the investigation of the impact of specific genetic mutations known to cause Parkinson's Disease on gene expression.
Impact This collaboration has resulted in a publication in Nature Communications and also prompted the submission of a successful project grant to the Alzheimer's Research Trust (£30,000). This is a project using the skills and knowledge of specialist cell biologists with my own technical skills in expression analysis.
Start Year 2011
 
Description eQTL analysis in control human cerebellum and frontal cortex 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution We have provided a considerable amount of processed gene expression data.
Collaborator Contribution This collaboration has allowed us to increase the power of our study by increasing the n number and has provided us with technical expertise regarding the analysis of eQTL data.
Impact We have a publication in submission as a direct result of this study.
Start Year 2010
 
Description eQTLs with relevance to brain anatomy as measured by MRI 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution We have provided region-specific eQTL data.
Collaborator Contribution The ENIGMA consortium have used MRI scanning and SNP genotyping to identify SNPs that relate to hippocampal volume among other measurements.
Impact This collaboration has resulted in the publication of a Nature Genetics paper.
Start Year 2011
 
Description "Alpha-synuclein & Parkinson's disease Conference: lessons from the past 20 years" Barcelona 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker to The University of Barcelona Medical School - Talk title: "Genetics of synucleinopathies"
Year(s) Of Engagement Activity 2017
 
Description "Do Genetic Findings Converge on Discrete Pathophysiological Pathways?" invited lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 12th National Alzheimer Disease Conference, Virtual Eskisehir Turkey
Year(s) Of Engagement Activity 2022
 
Description "Genomics in Neurodegenerative disease -- what are we up to" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture as HKUST IAS fellow, Hong Kong
Year(s) Of Engagement Activity 2019
 
Description "Neurogenetic Foundations of Movement Disorders - The Key to Cure?" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Keynote Lecture
Year(s) Of Engagement Activity 2019
 
Description "The Genetics of the Dementias" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Invited teaching lecture at Queen Square on MSc Human Genetics course 2018-19
Year(s) Of Engagement Activity 2019
 
Description 06/07/23 The role of genetics in the pathophysiology of PD 6th World Parkinson Congress in Barcelona On behalf of the Program Committee Invited Speaker 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 06/07/23 The role of genetics in the pathophysiology of PD 6th World Parkinson Congress in Barcelona On behalf of the Program Committee Roundtable Host.
Year(s) Of Engagement Activity 2023
URL https://wpc2023.org/page/ScientificProgram
 
Description 06/09/23 Invited Keynote speaker Leeds ARUK Network symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 06/09/23 Alzheimer's. From genetic analysis to treatment - KEYNOTE Leeds ARUK Network symposium Profs Anthony Turner and Renee Frank Invited Keynote speaker
Year(s) Of Engagement Activity 2023
 
Description 09/11/23 IAS Distinguished Lecture: The Genetics of the Major Neurodegenerative Diseases: From Mechanisms to Treatments 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 09/11/23 IAS Distinguished Lecture: The Genetics of the Major Neurodegenerative Diseases: From Mechanisms to Treatments HKUST Jockey Club Institute for Advanced Study Hong Kong Invited Speaker
Year(s) Of Engagement Activity 2023
 
Description 13/10/23 "Genetics of Alzheimer's Disease: its convergence on and divergence from amyloid hypothesis" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 13/10/23 "Genetics of Alzheimer's Disease: its convergence on and divergence from amyloid hypothesis" 13th National Alzheimer's Congress - Bodrum, Turkey Invitation Murat Emre And Bedia Samanci Behavioral Neurology and Movement Disorders Unit Istanbul Faculty of Medicine, Istanbul University Invited Opening Lecture
Year(s) Of Engagement Activity 2023
URL https://www.bing.com/videos/search?q=13th+National+Alzheimer%27s+Congress+%e2%80%93+Bodrum%2c+Turkey...
 
Description 15/09/23 Honorary doctorate seminar University of Rijeka, Croatia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 15/09/23 Honorary doctorate seminar University of Rijeka, Croatia On behalf of the University of Rijeka Madam Rector, Prof. Snježana Prijic-Samaržija, Ph.D.
Year(s) Of Engagement Activity 2023
 
Description 16/05/23 Virtual for Biomarkers Course Invited speaker Teaching 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact invited teaching talk by Romina Garrido on behalf of Mark Calvet Barcelona Beta Brain Research Center (BBRC) Virtual for Biomarkers Course.
Year(s) Of Engagement Activity 2023
 
Description 2017 EMBO conference on "Mechanisms of Neurodegeneration" at the EMBL Advanced Training Centre (ATC) in Heidelberg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Talk at EMO - Genomics of Neurodegeneration
Year(s) Of Engagement Activity 2017
 
Description 24th IUBMB Congress & 15th FAOBMB Congress - [IUBMB Seoul 2018] Invitation to be a Plenary Speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Plenary speaker - Talk title: 'Genomic analysis of late onset neurodegenerative diseases'
Year(s) Of Engagement Activity 2018
 
Description 2nd Regional DBS meeting - 'Deep brain stimulation: New Horizons in Neurology and Psychiatry' Westin Zagreb hotel. Zagreb, Croatia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - talk: Genomic analysis of neurological diseases and possible implications on society
Year(s) Of Engagement Activity 2017
 
Description 2nd international Taiwanese Congress of Neurology and 2017 Annual meeting of Taiwan Neurological Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - Talk title: Current Advance in Genetic Understanding of Parkinson's Disease
Year(s) Of Engagement Activity 2017
 
Description 30/10/23 Enhancing Basic Clinical Collaborative Research Engagement for Health and Well-Being 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 30/10/23 Enhancing Basic Clinical Collaborative Research Engagement for Health and Well-Being Plenary Speaker for 10th Faculty of Basic Medical Sciences Annual Scientific Conference - Nigeria - Virtual Invited by Prof AJ Akindele
University of Lagos, Nigeria Invited lecture
Year(s) Of Engagement Activity 2023
 
Description 31/10/23 Brain Health and the Latest Research into Dementia Prevention Dementia Summit 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 31/10/23 Brain Health and the Latest Research into Dementia Prevention Dementia Summit,
The King's Fund - No. 11 Cavendish Square, London W1G 0AN Invited speaker
Year(s) Of Engagement Activity 2023
 
Description 5th Venusberg Meeting, Bonn 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker to the meeting talk title: "The genomics of neurodegeneration"
Year(s) Of Engagement Activity 2017
 
Description A tribute to Stuart - talk about him as a person, colleague, and contributor to dementia research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact The Alzheimer's Research UK Conference
Brighton Centre, Kings Road, Brighton BN1 2GR
invited to speak in a session in memory of Stuart Pickering-Brown
Year(s) Of Engagement Activity 2022
 
Description AD research and future interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Virtual Interview Yasemin Saplakoglu
Biology Staff Writer
Quanta Magazine
C: (347) 585-9167
New York, New York
Year(s) Of Engagement Activity 2022
 
Description Advances in Alzheimer's Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker - The 10th Xiangya International Symposium of the Clinical and Basic Research on Neurodegenerative Disorders, China
Year(s) Of Engagement Activity 2019
 
Description Alzheimer's Association International Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mouseac Project: A Genome Wide Expression Analysis of Murine Models of Dementia According to Age and Brain Region Signifies the Importance of Microglial Pathways
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's disease pathogenesis: what do we know and why have clinical trials failed 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited public lecture
Year(s) Of Engagement Activity 2019
 
Description Amyloid hypoithesis.. what was right and what was wrong Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 6th Rijeka Forum on Neurodegenerative Disease Croatian Academy of Sciences and Arts
Department of Biomedical Sciences in Rijeka
Year(s) Of Engagement Activity 2022
URL https://neurolab.uniri.hr/?page_id=24#:~:text=The%206th%20Rijeka%20Forum%20of,of%20the%20amyloid%20c...
 
Description Aß hypothesis, AD genetics" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture - Wenner-Gren Center (Sveavägen 166), Stockholm, Sweden
symposium : "Amyloid diseases: from biochemistry to clinical applications"
Year(s) Of Engagement Activity 2019
 
Description Boston Neuroimmunology/AD Think Tank, Beauport Hotel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact What are the genetics of AD teaching us about the neuroimmune axis in neurodegeneration?
Year(s) Of Engagement Activity 2018
 
Description Brain Prize Lectures Royal Danish Academy of Science and Letters in Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Brain Prize Lecture - "Genomic Analysis outlines the pathogenesis of Alzheimers´s disease"
Year(s) Of Engagement Activity 2018
 
Description Crispr Talk - John and Selina 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited Lecture Royal London Hospital
Year(s) Of Engagement Activity 2019
 
Description Dementias - Invited Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%20in%20collaboration%20with%20thirteen,2022)%20at%20Fondazione%20Prada's%20Milan
invited Lecture
Year(s) Of Engagement Activity 2022
 
Description Dementias - Invited Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact "Preserving the Brain" is a forum on neurodegenerative diseases presented in September and October 2022, as the fourth phase of "Human Brains," Fondazione Prada's neuroscience project. Realized in collaboration with thirteen of the most prestigious international neuroscience institutes and universities, "Human Brains: Preserving the Brain - Forum on Neurodegenerative Diseases" comprises an exhibition (16 September - 10 October 2022) and a conference (6 and 7 October 2022) at Fondazione Prada's Milan premises and online.
"Preserving the Brain" aims to stimulate an open and critical exchange between international scientists and experts on neurodegenerative diseases, such as Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis and Multiple sclerosis, which are widely spread and as yet incurable. The forum participants include researchers, patient associations, and representatives of health care institutions and the pharmaceutical and biotechnology industries. They will debate the current state of knowledge of these diseases and the tools currently used to fight them, while also seeking to identify lacunae in the search for possible therapies, and jointly defining priorities and strategies to sustain scientific research.
Year(s) Of Engagement Activity 2022
URL https://www.fondazioneprada.org/project/human-brains-preserving-the-brain/?lang=en#:~:text=Realized%...
 
Description Department of Pharmacology, Mansfield Road, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Pharmacology, Anatomical Neuropharmacology and Drug Discovery Seminars - Talk title: Genomics of neurodegenerative diseases
Year(s) Of Engagement Activity 2018
 
Description Epidemiology of Alzheimer's Disease and Related Disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Keynote speaker on teaching course at Bordeaux School of Neuroscience
Year(s) Of Engagement Activity 2019
 
Description ExCel - Humans Theatre New Scientist Live 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact When will we cure Alzheimer's and Parkinson's?
Year(s) Of Engagement Activity 2017
 
Description Faculty of Medicine, University of Iceland Vatnsmyrarvegur 16 101 Reykjavik - Iceland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished speakers series
Year(s) Of Engagement Activity 2017
 
Description Failures in Damage Response Underlie Late Onset Neurodegenerative Diseases and Explain the Relationship Between Pathology and Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Virtual
UK-Russia online forum on Neurodegenerative Diseases and Brain Plasticity
Requested by
Alena Gureva | Science and Innovation Officer, UK Science & Innovation Network in Russia
British Embassy Moscow | Smolenskaya Naberezhnaya, 10 | Moscow 121099
Year(s) Of Engagement Activity 2022
 
Description Francis Crick Institute - main auditorium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Crick Lecture - Genomic analysis of neurodegenerative disease
Year(s) Of Engagement Activity 2018
 
Description Genetic Analysis of Neurodegeneration Implicates a Failure of Damage Response Pathways Pre-recorded and live Q&A 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Neural Pathways Underlying Brain Function and Pathologies Organized by: Nature Portfolio, Chinese Institute for Brain Research, Beijing (CIBR)
Supported by: Beijing Municipal Science & Technology Commission, Administrative Committee of Zhongguancun

This event aims to bring together Chinese and international researchers at the forefront of brain science to share their recent achievements in helping to push our understanding forward under both normal and pathological conditions.
Year(s) Of Engagement Activity 2022
URL https://neuralpathways.natureresearch.cn/
 
Description Genetic analysis of late onset degenerative diseases implicates failures of damage response 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Speaker invitation and Announcement of The Brain Prize Awardee 2019 Copenhagen, Denmark
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited Lecture - Wolfson Institute for Biomedical Research (WIBR) mini-symposium - Sainsbury Wellcome Centre London
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Wolfson final symposium - Institute of Child Health London
Year(s) Of Engagement Activity 2019
 
Description Genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Invited Lecture Weston's meeting - 50th Year Anniversary Symposium, 33 Queen Square
Year(s) Of Engagement Activity 2019
 
Description Genetics and neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited to present a teaching lecture to the Basal Ganglia Club Gilliatt Lecture Theatre Queen Square by Dr Amit Batla MBBS, MA (Clin Ed), MD (Med), DM (Neurology), FRCP
Clinical Associate Professor (teaching), Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology
Year(s) Of Engagement Activity 2022
 
Description Genetics in neurodegenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture at 2019 International Conference of Korean Dementia Association, (IC-KDA 2019) Seoul
Year(s) Of Engagement Activity 2019
 
Description Genetics in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited teaching to PhD students on Biomarkers for neurodegenerative diseases PhD course
Year(s) Of Engagement Activity 2019
 
Description Genetics in neurodegenerative diseases - teaching lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact "Biomarkers for neurodegenerative diseases" Day 1 - London edition PhD course "Biomarkers for neurodegenerative diseases" - 2022
Year(s) Of Engagement Activity 2022
URL https://www.ucl.ac.uk/ion/study/biomarkers-neurodegenerative-diseases
 
Description Genetics of Alzheimer's 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecture at Hong Kong University of Science and Technology ShenZhen branch
Year(s) Of Engagement Activity 2019
 
Description Genetics of Alzheimer's and other neuro-degenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture - China National Genebank - Jinsha Road, Dapeng New District, Shenzhen
Year(s) Of Engagement Activity 2019
 
Description Genetics of Dementias 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture XXIV World Congress of Neurology, Dubai - AE
Year(s) Of Engagement Activity 2019
 
Description Genetics of Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture at Lisbon AD/PD meeting
Year(s) Of Engagement Activity 2019
 
Description Genomic Analysis of Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Zoom Teaching lecture - invited by Dr Kerri Kinghorn
ucl lectures Neurological diseases module GENE003
Year(s) Of Engagement Activity 2022
 
Description Genomic analysis of neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited lecture Scientific Talk (to senior scientists) Odense University Hospital, Denmark
Year(s) Of Engagement Activity 2019
 
Description Genomic analysis of the mechanisms of neurodegenerative disease in Denmark to PhD students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Teaching Lecture to PhD students in neuroscience at the NeuroGrad Winter School, Copenhagen
Year(s) Of Engagement Activity 2019
URL https://neurograd.ku.dk/neurograd-winter-school/
 
Description Genomic clues to neurodegenerative disease mechanisms 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Brain Prize Special Lecture/ keynote lecture at ECNP Congress in Copenhagen
Year(s) Of Engagement Activity 2019
 
Description Genomics of Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture - 3rd Rijeka Forum on Neurodegenerative diseases, Croatia Rijeka
Year(s) Of Engagement Activity 2019
 
Description Genomics of neurodegenerative disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Keynote speaker FENS The Serbian Neuroscience Society. with the Neuroscience societies of Romania and Turkey.
Belgrade Serbia.
Year(s) Of Engagement Activity 2019
 
Description Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Grand Rounds Invitation: Albert Einstein College of Medicine - Montefiore Medical Center talk entitled: Genomic analysis of neurodegenerative diseases implicates failures of damage clearance with Q&A
Year(s) Of Engagement Activity 2021
 
Description Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker to Hong Kong Student Association of Neuroscience (HKSAN) - Neuroscience: Past, Present, Future Symposium of 1st Asia-Pacific Neuroscience Student Congress and HKSAN 2nd Annual Conference (APNSC-HKSAN) 2021. Talk entitled: Whole genome analysis of neurodegeneration
Year(s) Of Engagement Activity 2021
URL https://www.hksaneuroscience.org/apnsc-hksan-programme
 
Description INTERVIEW with- Camilla De Fazio - Popular Science about the FDA approval of the first new drug for Alzheimer's disease - 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact INTERVIEW with- Camilla De Fazio - Popular Science about the FDA approval of the first new drug for Alzheimer's disease
Year(s) Of Engagement Activity 2021
URL http://www.popsci.it/approvazione-di-aducanumab-contro-lalzheimer-una-svolta-tra-molte-incertezze.ht...
 
Description ISMND Science Webinar Series 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Invited speaker by Diane Bovenkamp, Ph.D. Vice President, Scientific Affairs, BrightFocus Foundation
Genomic analysis of neurodegenerative disease reveals commonalities between them and point the way towards therapies
Year(s) Of Engagement Activity 2023
 
Description Inaugural Baillieu Myer Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Inaugural Baillieu Myer Lecture, in honour of contribution to medical research, in particular dementia research
Year(s) Of Engagement Activity 2019
 
Description Institute of Neurology seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The Fifteenth Pewterers' Lecture "What is the basis of selective vulnerability in neurodegenerative diseases?"
Year(s) Of Engagement Activity 2018
 
Description Interview with USA Today Health Reporter Ken Alltucker 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with USA Today Health Reporter Ken Alltucker about results of new Alzheimer drug trials
Year(s) Of Engagement Activity 2022
 
Description Invited Interview for YouTube Channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Recording for the Wonderbirds show - Filmed interview
Year(s) Of Engagement Activity 2023
URL https://www.youtube.com/watch?v=1Mp1E4pYE2k
 
Description Invited Interview with the Daily Mail Newspaper for new Alzheimer drugs 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 11/05/23 Daily Mail's Good Health supplement on the newer drugs for Alzheimer's Zoom recording with the Daily Mail Jo Waters Daily Mail Invited Interview
Year(s) Of Engagement Activity 2023
 
Description Invited Interview with the Financial Times 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 09/06/23 Lecanemab Interview Financial Times story Hannah Kuchler
Global Pharmaceuticals Correspondent
Financial Times Invited Interview
Year(s) Of Engagement Activity 2023
 
Description Invited Interview/Q&A - Biomarkers for neurodegenerative diseases 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cars and Scientists short film series, now supported by Jackie Stewart's charity Race Against Dementia
Year(s) Of Engagement Activity 2022
URL https://www.raceagainstdementia.com/research/accelerating-research/
 
Description Invited Keynote speaker - Genomic analyses of neurodegenerative diseases for Genomics of Brain Disorders 2023 - Wellcome Genome Campus, near Cambridge, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 19/05/23 Genomic analyses of neurodegenerative diseases Genomics of Brain Disorders 2023 - Wellcome Genome Campus, near Cambridge, UK
Invited Keynote speaker
On behalf of the Scientific Programme Committee:
• Cornelis Blauwendraat NIH/National Institute on Aging, USA
• Kristen Brennand Yale University, USA
• Anders Børglum Aarhus University, Denmark
• Mina Ryten UCL Great Ormond Street Institute of Child Health, UK Keynote speaker
Teaching
Year(s) Of Engagement Activity 2023
 
Description Invited Plenary Lecture for ABN meeting in Belfast 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 10/05/23 "The Genetics of Neurodegenerative Disease" ABN (Belfast) Invited by ABN meetings secretary PLENARY LECTURE
Year(s) Of Engagement Activity 2023
 
Description Invited Round table public talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited public round table - Brain Prize Evening - Lundbeck - BNA Festival, The Convention Centre Dublin
Year(s) Of Engagement Activity 2019
 
Description Invited Speaker - 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker to 5th RIJEKA FORUM ON NEURODEGENERATIVE DISEASES NEURODEGENERATIVE DISEASES: TOWARD THERAPY
Talk entitled: Genetic analysis of decline of disease rate
Year(s) Of Engagement Activity 2021
URL https://uniri.hr/wp-content/uploads/2021/11/Simpozij-49_finalno.pdf
 
Description Invited Speaker 30th Adler Symposium on Alzheimer's Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Goal of the Symposium
The 30th anniversary Adler Symposium will focus on issues that are directly relevant to Alzheimer's disease (AD) or on therapies for other disorders that may impact AD. There are four major themes: 1) AD diagnostics and therapeutics; 2) Non-AD therapies that could impact our thinking about AD; 3) Role of genetics, epigenetics, and innate immunity in AD; 4) Brain cell senescence and systemic factors that influence neurodegeneration.
The overall format of the meeting should also provide plentiful opportunities for informal interchanges among all the speakers and participants.
Year(s) Of Engagement Activity 2023
 
Description Invited interview for BBC Radio 4 Today programme interview with VICTORIA GARDINER Senior Journalist on new Alzheimer drugs 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact BBC Radio 4 Today programme invited interview with VICTORIA GARDINER Senior Journalist for new Alzheimer drugs
Year(s) Of Engagement Activity 2023
 
Description Invited lecture - Alector Seminar and round table 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Invited speaker entitled: Genomic analysis of neurodegeneration implicates proteostasis as the key problem in late-onset disease followed by round-table discussions
Year(s) Of Engagement Activity 2021
 
Description Invited speaker - The Genetics Society of Korea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Invited Plenary Speaker to The Genetics Society of Korea
Year(s) Of Engagement Activity 2021
URL https://www.illumina.com/content/illumina-marketing/spac/en_AU/events/conferences/2021/icgsk-2021.ht...
 
Description Invited speaker NIH Clinical Neuroscience Grand Rounds Main Lecture Speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker talk entitled: Genomic Analysis of the Major Neurodegenerative Diseases - NIH Clinical Neuroscience Grand Rounds with Q&A
Year(s) Of Engagement Activity 2021
 
Description Invited speaker to 45th FEBS Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Talk entitled: Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk at 45th FEBS conference
Year(s) Of Engagement Activity 2021
URL https://2021.febscongress.org/
 
Description Invited speaker to The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD) Eisai-sponsored Satellite symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk entitled:The biological and genetic evidence of the Aß pathway
The 15th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD)
Eisai-sponsored Satellite symposium
Year(s) Of Engagement Activity 2021
URL https://adpd2021.kenes.com/
 
Description Invited talk to the Elderly 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Invited speaker at Chinese Dementia Meeting at Community Elder Center at Hebei, China
Year(s) Of Engagement Activity 2019
 
Description Keynote Lecture - Genomics of Neurodegeneration: On the way to therapies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 13/06/23 Keynote Lecture - Genomics of Neurodegeneration: On the way to therapies IOE, UCL's Faculty of Education and Society, 20 Bedford Way, Bloomsbury, WC1 Invitation from UCL Professors Trevor Smart and Antonella Riccio UCL 14th edition Neuroscience Symposium - keynote speaker bringing together over 800 Neuroscientists, policy and industry attendees. Delegates have the chance to create new cross-disciplinary links, foster collaboration between basic and clinical researchers and visit our trade exhibition
Year(s) Of Engagement Activity 2023
 
Description Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course: Genomic analysis of neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Keynote Presentation Molecular Neurodegeneration and Therapeutic Approaches course - Genomic analysis of neurodegeneration Wellcome Genome Campus in person Hinxton, Cambridgeshire
Year(s) Of Engagement Activity 2022
URL https://coursesandconferences.wellcomeconnectingscience.org/event/molecular-neurodegeneration-and-th...
 
Description Keynote Speaker of the Karolinska Institute StratNeuro Neuroscience Symposium 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - talk title: Genomics of neurodegeneration
Year(s) Of Engagement Activity 2018
 
Description Keynote at CTAD 2017 10th edition of Clinical Trials on Alzheimer's Disease (CtaD2017) held in Boston, MA - USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Genetic Aspects In Clinical Trials
Year(s) Of Engagement Activity 2017
 
Description Keystone Conference in Colorado - New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - Talk title: Genetics in Neurodegenerative Diseases
Year(s) Of Engagement Activity 2018
 
Description MRC/BTR event - Neurosciences and Brain Tumour Research: Joining Forces for Greater Impact BEIS Conference Centre, 1 Victoria Street, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited speaker - Plenary talk
Year(s) Of Engagement Activity 2018
 
Description Meet the Professors 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Round table public talk
Year(s) Of Engagement Activity 2019
 
Description Meeting EMBO - Basal Life 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Plenary session 4 Genes to disease and therapies - René Bernards, Botond Roska, Christine Petit, John Hardy
Year(s) Of Engagement Activity 2017
 
Description Multiple Media Interviews on latest drug release for Alzheimer's. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 17/07/23 Interviews following the announcement of the results of the drug trials on Donanemab whilst at the AAIC meeting in Amsterdam. AAIC Conference Amsterdam
1. BBC TV news
2. BBC Today Radio
3. BBC Radio Wales
4. Radio Scotland
5. Radio Northern Ireland
SEPARATE INTERVIEWS WITH JOURNALISTS Public Engagement
Year(s) Of Engagement Activity 2023
 
Description Neanderthals - talk for The National Trust 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Lecture in response to a request to talk to a regional National Trust membership
Year(s) Of Engagement Activity 2019
 
Description New Scientist Invited Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 22/05/23 The future of Alzheimer's treatments Interview for feature sponsored by Eisai Michael Brooks - New Scientist Invited Interview
Year(s) Of Engagement Activity 2023
 
Description Opening lecture: Alzheimer's disease: a personal view on early diagnosis and treatment 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture - XVIII Teófilo Hernando's International Summer School of Pharmacology
Frontier Biomarkers and Drug Discovery for the Early Diagnosis and Treatment of Alzheimer's Disease
Year(s) Of Engagement Activity 2019
 
Description Pan-London regional teaching day for all the neurology registrars in London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Pan-London regional teaching day for all the neurology registrars in London - talk - Genomics and neurology
Year(s) Of Engagement Activity 2017
 
Description Parkinson's Disease Gordon Research Conference. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Parkinson's Disease Genetics and Systems Biology- Discussion Leader
Year(s) Of Engagement Activity 2017
 
Description Pre-congress Course I - Advances in Research, Science & Treatment - Teaching 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 04/07/23 Pre-symptomatic genetic testing in predicting PD 6th World Parkinson Congress in Barcelona Invitation On behalf of the Program Committee Pre-congress Course I - Advances in Research, Science & Treatment - Teaching
Year(s) Of Engagement Activity 2023
URL https://wpc2023.org/page/AboutCongress
 
Description Progress in the genomic analysis of neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture to the department of Neurodegenerative Disease as an update on work in progress
Year(s) Of Engagement Activity 2019
 
Description Promoting Healthy Brain Aging and Preventing Dementia: Research and Translation, taking place from the Banff Centre for Arts and Creativity in Banff, Alberta 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact keynote address - Genomic analysis of neurodegeneration
Year(s) Of Engagement Activity 2018
 
Description Rethinking PD: From a Single Disease to Multiple Diseases:: Genetics, Epigenetics and Environmental Factors 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture by The Preuss Foundation Seminar on State of the Art Parkinson's Disease Research ~ La Jolla, California
Year(s) Of Engagement Activity 2019
 
Description Second Rijeka Forum for neurodegenerative diseases 2018 Croatia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Speaker - Talk title: Genomic analysis of neurodegenerative diseases and possible implications on society
Year(s) Of Engagement Activity 2018
 
Description Session 4 - Panel discussion: 'The Future of Neuroscience' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited Lecture - UCL Neuroscience Symposium 10th Anniversary, UCL Institute of Education
Year(s) Of Engagement Activity 2019
 
Description Skype 2 hour lecture to students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Teaching Lecture to Masters Students
"Athens International Master's Programme in Neurosciences"
University of Athens
Department of Biology
Year(s) Of Engagement Activity 2019
 
Description Stanford University - Brain Rejuvenation Mini-symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker Stanford University - Brain Rejuvenation Mini-symposium
Year(s) Of Engagement Activity 2018
 
Description Talk for the Cardiff Gene Park to sixthformers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact The talk sparked discussion following the event

No notable impact yet
Year(s) Of Engagement Activity 2014
 
Description Talk to Grand Rounds at Royal London Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Talk entitled: Genomic analysis suggests failing damage responses underlie diseases to the Grand Rounds of the Royal London Hospital
Year(s) Of Engagement Activity 2021
 
Description Tau 2020 Conference in Washington 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invitation to Present latest updates at Tau 2020 - On behalf of the Alzheimer's Association, the Rainwater Foundation, and CurePSP to move Tau research forward
Year(s) Of Engagement Activity 2020
URL https://www.alz.org/tau2020/overview.asp
 
Description Teaching Lecture - PhD course "Biomarkers for neurodegenerative diseases" - 2021 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited teaching lecture entitled: Genetics in neurodegenerative diseases with Q&A afterwards
Year(s) Of Engagement Activity 2021
 
Description Teaching lecture UCL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Genetics of Neurological diseases module GENE003 UCL
Year(s) Of Engagement Activity 2021
 
Description Teaching lecture UCL - The importance of genetics and molecular biology in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Teaching lecture - for the Clinical Neuroscience MSc 33 QS Lecture Theatre
Year(s) Of Engagement Activity 2022
 
Description The 12th World Congress on Controversies in Neurology (CONy), Warsaw, Poland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - talk title: Insights from genomic analysis of neurodegeneration
Year(s) Of Engagement Activity 2018
 
Description The Roy M. Huffington Distinguished Lecture at Baylor College of Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Speaker - Genomic Analysis of Neurodegeneration
Year(s) Of Engagement Activity 2017
 
Description The importance of genetics and molecular biology in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invitation to Lecture on MRes Translational Neuroscience programme - 7 Queen Square
Year(s) Of Engagement Activity 2019
 
Description The importance of genetics and molecular biology in neurodegenerative diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Invited teaching UCL - Basic neuroscience and investigation of Nervous system - CLNE0009 Queen Square
Year(s) Of Engagement Activity 2019
 
Description The role of genetics and genetic testing in PD 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture at World Parkinson Coalition 2019 Kyoto, Japan
Year(s) Of Engagement Activity 2019
 
Description University Menéndez Pelayo, in the course XVI International School of Pharmacology <>. Understanding the Human Brain. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Teaching session - Understanding Brain Diseases - Alzheimer's Disease
Year(s) Of Engagement Activity 2017
 
Description University of Manchester 2nd Lecture Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 'Nanotechnology in Neurology and Neurosciences - Keynote Lecture
Year(s) Of Engagement Activity 2017
 
Description Visit and seminar Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker - Talk title: Genomic clues as to the reasons for selective vulnerability in neurodegenerative disease
Year(s) Of Engagement Activity 2017
 
Description Visit to Columbia University New York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Advances in Precision Medicine: Genetics - Dr Hardy focuses on the genetic analysis of complex traits related to neurological disease, and in population genetics to understand the underlying genetics of a disorder so he can work with those making cellular and animal models of the disease to help, both in the understanding of disease mechanisms and to help in the search for treatments
Year(s) Of Engagement Activity 2017
 
Description Visit to First AoE IAB Meeting - Hong Kong HKUST Jockey Club Institute for Advanced Study 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker - IAS Distinguished Lecture - Genomic analysis of neurodegenerative disorders
Year(s) Of Engagement Activity 2018
 
Description Visit to Japan University of Tokyo 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Alzheimer's Scientific Roundtable
Year(s) Of Engagement Activity 2018
 
Description Visit to Lecture Theatre 2 Southampton General Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact PDA Christmas Lecture
Genomic analysis of neurodegenerative diseases suggests that failure in damage response is a critical issue
Year(s) Of Engagement Activity 2018
 
Description Visit to Lundbeck Institute Denmark 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Why has amyloid therapy not worked; Genomics of neurodegeration
Year(s) Of Engagement Activity 2018
 
Description Visit to The Medical School Queen's Medical Centre Nottingham NG7 2UH 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Life Sciences Annual Lecture - 12 July 2018 - Genomics and neurodegenerative disease
Year(s) Of Engagement Activity 2018
 
Description Visit to The Rockefeller University 1230 York Ave. New York, NY 10065 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The Rockefeller University Friday Lecture - Genomic analysis of Alzheimer's disease and other neurodegenerative disorders
Year(s) Of Engagement Activity 2018
 
Description Visit to Yale University School of Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 2018 Sackler Lectureship at Yale
Year(s) Of Engagement Activity 2018
 
Description Webinar Series Lecture Neuroscience in Africa 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Genetics of Parkinson's Disease: Understanding the Differences between European & African Populations. to raise awareness in Africa
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=Lf6woi9zKCs
 
Description Website - Alzforum 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview has sparked online comments

Requests for data sharing
Year(s) Of Engagement Activity 2014
 
Description Website - SAFARI 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The report has sparked interest in our data set and resources

I have been e-mailed for specific data
Year(s) Of Engagement Activity 2014
 
Description What is the relationship between mendelian disease and sporadic disease (and how does the environment fit in?) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Third UCL Queen Square Motor Neuron Disease Centre International Symposium Lecture Theatre, 33 QS
Invited KEYNOYE Speaker
Year(s) Of Engagement Activity 2022
URL https://www.ucl.ac.uk/ion/events/2022/sep/third-ucl-queen-square-motor-neuron-disease-centre-virtual...
 
Description Where is genetics leading us: The future of genetics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact UCL Teaching lecture - Neuromuscular Disease MSc/MRes Advanced genetic technologies and clinical applications module
invited by David Blundred - Education Unit - Institute of Neurology
Year(s) Of Engagement Activity 2022
 
Description Wolfson Seminar on Neurodegeneration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I spoke about the potential clinical use of transcriptomics in clinical practice and for the understanding of neurodegenerative disorders.
Year(s) Of Engagement Activity 2016
 
Description Workshop on Alzheimer's Disease and Related Disorders, FBRI Meeting, Kronberg, Germany 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation workshop facilitator
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Hardy led the workshop. Exchange of ideas and information.

Excellent feedback. Participants reported being pleased with the intellectual stimulation.
Year(s) Of Engagement Activity 2015
 
Description invited interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview to discuss the latest study in the Lancet which suggests By 2050, more than 153 million people could have dementia, up from 57 million in 2019, and that more than one in 50 people in Britain will be living with dementia by 2050.
Public knowledge
The interview in English, around 5min, aired on BBC World TV and ran several times in full.
As a reminder BBC world TV has more than 122 million viewers a week and in more than 200 countries. Their website receives more than a billion views a month
Year(s) Of Engagement Activity 2022
 
Description invited lecture 25th National Dementia Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact presentation - Alzheimer's disease: from genetic analysis to mechanistic treatments, with Q&A Thursday 9th February
Year(s) Of Engagement Activity 2023
 
Description invited speaker - Understanding the endosomal pathway in neurodegeneration' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Royal Society Hooke Discussion Meeting Organised by Professor Peter Cullen, Professor Peter St George-Hyslop FRS, Professor Scott Small and Dr Henne Holstege

Understanding the endosomal network in neurodegeneration
21 - 22 November 2022
The Royal Society, London and online
Year(s) Of Engagement Activity 2022
 
Description invited speaker 12th European Congress of Neuropathology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Lecture entitled: Clues to the aetiology of neurodegenerative diseases from genomic analysis at 12th European Congress of Neuropathology
Year(s) Of Engagement Activity 2021
URL https://www.ecnp2020.dk/
 
Description invited speaker Scientific Steering Committee of the Global Symposium on Lysosomal Storage Disorders (GSLSD) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 1. Deliver a presentation on the theme of "Mechanisms that underly the relationships between specific gene defects and nervous system dysfunction/damage"

2. • Participate in an interactive live Q&A and panel discussion related to the question "Why is there high phenotypic variability in patients with the same lysosomal storage diseases? Is this any different from other monogenic diseases?"

Scientific Steering Committee of the Global Symposium on Lysosomal Storage Disorders (GSLSD)
Year(s) Of Engagement Activity 2022
 
Description talk on Genetics at McGill University in Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited Lecture
Year(s) Of Engagement Activity 2019
 
Description talk to first virtual Congress of the Neurological Association of South Africa 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two lectures for the first virtual Congress of the Neurological Association of South Africa
1. Genetic analysis of Alzheimer's and Parkinson's disease, damage response failure as the underlying
problem of the disease
2. Genetic prediction of sporadic disease
Year(s) Of Engagement Activity 2021
URL https://www.nasacongresses.co.za/