Regulation of synapse health and tau release by CSP in Alzheimer's disease
Lead Research Organisation:
King's College London
Department Name: Clinical Neuroscience
Abstract
Cognitive impairment associated with Alzheimer's disease (AD) correlates best with synapse loss and tau pathology (Spires-Jones and Hyman, 2014). The mechanisms that lead to synapse loss and protection in AD, and the relationship between synapse loss and the prion-like propagation of tau pathology across diseases brain regions, are not known. However, circumstantial evidence suggests that cysteine string protein alpha (CSP) is a critical player in both processes (Tiwari et al., 2015; Fontaine et al., 2016). This project aims to determine the implications of temporal changes in CSP abundance for synapse health and tau release during tau progression in AD. Aim 1: To investigate whether alterations in CSP levels are a sensitive marker of synaptic protection and degeneration at different stages of AD progression. Aim 2: To investigate the effect of altered CSP abundance at synapses on tau release during the development of tau pathology in AD.
Organisations
People |
ORCID iD |
| Wendy Noble (Primary Supervisor) | |
| Huzefa Rupawala (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013700/1 | 01/10/2016 | 30/09/2025 | |||
| 1847273 | Studentship | MR/N013700/1 | 26/09/2016 | 30/11/2020 | Huzefa Rupawala |
| Description | Alzheimer's Research UK Pump Priming Grant |
| Amount | £5,000 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 08/2019 |
| Description | Alzheimer's Research UK Travel Grant |
| Amount | £500 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2018 |
| Description | Alzheimer's Research UK Travel Grant |
| Amount | £500 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2017 |
| Description | Alzheimer's Research UK Travel Grant |
| Amount | £800 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2019 |
| Description | Alzheimer's Research UK Travel Grant |
| Amount | £500 (GBP) |
| Organisation | King's College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2019 |
| Description | MRC DTP Flexible Supplement |
| Amount | £1,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 10/2018 |
| Description | MRC DTP Flexible Supplement |
| Amount | £2,570 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 11/2019 |
| Description | Alzheimer's Research UK Conference 2019 Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | I was given the opportunity at this national conference to present my research too an audience of over 100 PhD students and early career researchers. It was a great opportunity to share my ideas with other dementia researchers and sparked many questions and creativity that would allow me to pursue new directions within my own research. It also provided me the confidence to speak at a profound conference and infront of large audiences. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC Brain Bank Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I presented a talk on my research to assist in the Brain Bank open day for the general public and charitable donors to increase awareness of dementia and also to demonstrate the kind of research being conducted within the facility. We had upto 50 attendees visit the research organisation and sparked many questions with regards to finding possible treatments and mechanisms in order to aid a cure, quality of care and better treatments overall. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Engagement at Science Museum |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Public engagement opportunity at the London Science museum. Engaging public talking to them about dementia. Conducted practical sessions with both children and adults on how to dissect fruit under the microscope and how to culture cells using different chemical solutions. This sparked many questions, put their skills to the test and many discussions. This increased the interest of the public to understand about dementia and its impact but also getting children involved to speak about such a complex topic. |
| Year(s) Of Engagement Activity | 2018 |