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Identifying novel targets for treating pain in Parkinson's disease by unravelling the neuroimmune contribution.

Abstract

The overall objective of this project is to investigate the cellular and molecular mechanisms underlying pain in Parkinson's disease. Specifically, we hypothesise that microglial activation in descending pathways from the brain modulates pain signalling at the spinal cord level and contributes to neuroinflammation-driven pain in Parkinson's. This collaboration between pre-clinical experts in Parkinson's (Dr Duty) and pain (Professor Malcangio) and leading clinical expert in pain in Parkinson's (Professor Chaudhuri) aims to find novel analgesic targets for better treating pain in Parkinson's patients.

Publications

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Buhidma Y (2020) Potential of animal models for advancing the understanding and treatment of pain in Parkinson's disease. in NPJ Parkinson's disease

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Clarke E (2019) Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia. in Neurochemistry international

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Rukavina K (2019) Pain in Parkinson's disease: new concepts in pathogenesis and treatment. in Current opinion in neurology

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013700/1 30/09/2016 29/09/2025
1931742 Studentship MR/N013700/1 30/09/2017 29/06/2022 Yazead Buhidma