Investigating the effect aortic pathological flow on vascular smooth muscle cell ECM and the consequences for aortic dilation and aneurysm
Lead Research Organisation:
King's College London
Department Name: Imaging & Biomedical Engineering
Abstract
To better characterize the mechanistic origin of vascular aneurysms, and to propose diagnostic thresholds for the management of clinical conditions such as a bicuspid aortic valve.
People |
ORCID iD |
| Eileen Gentleman (Primary Supervisor) | |
| Suzette Lust (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013700/1 | 01/10/2016 | 30/09/2025 | |||
| 1937722 | Studentship | MR/N013700/1 | 01/10/2017 | 30/03/2023 | Suzette Lust |
| Description | MRC Flexible Supplement Fund opens for application |
| Amount | £3,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 05/2019 |
| Description | Collaboration with Cellule, a design studio |
| Organisation | Cellule Studio |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Public engagement journey, delivering Big Heart Data, Kalostasis and Echoes - http://cmib.website/public-engagement/ |
| Collaborator Contribution | Cellule championed the artistic/design aspects of the public engagement activities |
| Impact | Engaged with thousands of visitors Building a research proposal with one of the visitors |
| Start Year | 2018 |
| Description | Modelling and Design collaboration |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | N/A |
| Collaborator Contribution | This collaboration has aided in the mathematical modelling of the bioreactor system we are designing and vital practical advice in experimental flow setups. |
| Impact | This collaboration is multidisciplinary involving mathematical modelling, computational modelling, engineering experimental biomaterials and cell culture. |
| Start Year | 2018 |
| Description | Echo happiness hub workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | I helped run an activity workshop for the ECHO happiness hub. Working with an artist Jenny Leonard we conducted drawing activities whilst Jenny interviewed me on my research. The workshop was broadcast live and continues to be available on YouTube and the ECHO charity website |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://echo-uk.org/happiness-hub/ |
| Description | Kalostasis Exhibit at the V+A museum |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Kalostasis is an interactive design exhibition demonstrating the impact of disruption to flow within the Aorta and different fluid flow patterns that can arise. A workshop was held for children and adolescents through the ECHO charity which supports children and young people with heart conditions and their families who've been treated by Evelina London Children's Hospital networks. I took the group through the exhibition and helped explain some of the science behind the design as well as explaining some of the research our group is doing to understand and tackle disease. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://echo-uk.org/2019/10/09/kalostasis/ |
| Description | Native Scientist Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I assisted at the "Operating Theatre of the Future" exhibition for KCL at the New Scientist Live Exhibition. We interacted with members of the public, school children and research colleagues as well as industry about our research mapping changes in the heart and vasculature. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://live.newscientist.com/the-future-of-healthcare#/ |
| Description | Native Scientist School Visit (Wix Primary School) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A team of 4 researchers from KCL went to Wix primary school to present to a group of children aged 10-11 our research in their native language French. The children were exposed to different areas of biomedical engineering and imaging research as well as getting an opportunity to learn more generally about being a scientist. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.nativescientist.com |