Elucidating the effects of insulin signalling on T cell metabolism and effector function within the tumour microenvironment
Lead Research Organisation:
University of Cambridge
Department Name: Pathology
Abstract
Recent evidence has shown the importance of insulin signalling for activated T cells, supporting metabolic reprogramming and enhancing effector function in viral infection and autoimmunity models. Our group has identified that insulin levels are profoundly diminished within interstitial fluid extracted from tumours, suggesting that abrogated insulin signalling could partially explain metabolic insufficiencies of effector T cells within tumours. My project will test the hypothesis that insulin availability in the tumour microenvironment is limited, restricting glucose uptake, T cell activation and ultimately hampering effective anti-tumour immunity and immunotherapy. We will test the hypothesis using murine tumour models, CRISPR-mediated knockout systems, in vitro functional assays, epigenomic and transcriptomic techniques
Organisations
People |
ORCID iD |
Rahul Roychoudhuri (Primary Supervisor) | |
Alexander Evans (Student) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
MR/N013433/1 | 01/10/2016 | 30/04/2026 | |||
2620298 | Studentship | MR/N013433/1 | 01/10/2021 | 30/09/2025 | Alexander Evans |