Causes and consequence of short tandem repeat instability
Lead Research Organisation:
University of East Anglia
Abstract
Faithful copying of the genome is essential for all life on earth. In addition to DNA replication, the genome must also be transcribed. However, a specific DNA sequence can only be engaged in either replication or transcription at any one time. Therefore, there are frequently conflicts between the processes of transcription and replication that have the potential to result in genome instability. Cells have efficient pathways to prevent transcription-replication conflicts. However, these pathways are not well understood. We have recently developed a novel genomic technology that can detect transcription-replication conflicts - this will allow us to discover pathways that the cell
uses to protect the genome.
uses to protect the genome.
Organisations
People |
ORCID iD |
Conrad Nieduszynski (Primary Supervisor) |
Studentship Projects
Project Reference | Relationship | Related To | Start | End | Student Name |
---|---|---|---|---|---|
BB/T008717/1 | 01/10/2020 | 30/09/2028 | |||
2869560 | Studentship | BB/T008717/1 | 01/10/2023 | 30/09/2027 |